文献一覧: Masahiro Ishikane (著者)

72 0 0 0 OA FDG-PET/CT images of COVID-19: a comprehensive review

著者: Ryogo Minamimoto Masatoshi Hotta Masahiro Ishikane Takeshi Inagaki
出版者: National Center for Global Health and Medicine
雑誌: Global Health & Medicine (ISSN:24349186)
巻号頁・発行日: pp.2020.01056, (Released:2020-07-20)
参考文献数: 46
被引用文献数: 20

Following a lot of reports of coronavirus disease 2019 (COVID-19) CT images, the feature of FDG-PET/CT imaging of COVID-19 was reported in several articles. Since FDG accumulates in activated inflammatory cells, FDG-PET/CT has huge potential for diagnosing and monitoring of inflammatory disease. However, FDG-PET/CT cannot be routinely used in an emergency setting and is not generally recommended as a first choice for diagnosis of infectious diseases. In this review, we demonstrate FDG-PET/CT imaging features of COVID-19, including our experience and current knowledge, and discuss the value of FDG-PET/CT in terms of estimating the pathologic mechanism.

2020-08-08 18:16:28
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36 0 0 0 OA A single-center descriptive study of untraced sources of infection among new cases of coronavirus disease in Tokyo, Japan

著者: Sayaka Hikida Shinichiro Morioka Naoki Fujii Taichi Tajima Yuriko Terayama Yuriko Sugiura Masahiro Ishikane Jin Takasaki Masayuki Hojo Norio Ohmagari
出版者: National Center for Global Health and Medicine
雑誌: Global Health & Medicine (ISSN:24349186)
巻号頁・発行日: pp.2021.01092, (Released:2021-08-10)
参考文献数: 8
被引用文献数: 2

We investigated possible sources of newly infected patients with coronavirus disease (COVID-19) after the fourth wave in order to explore unknown sources. Retrospective chart review on all the confirmed patients with COVID-19 admitted to the National Center for Global Health and Medicine (NCGM) in Tokyo, Japan was conducted from May 22 through June 29, 2021. Among the 22 participants, 14 (64%) had a history of known high-risk infection behaviors. Of those, 12 reported that their activities involved eating and drinking. In addition, there were 24 high-risk situations, of those, 21 (88%) were related to indoor dining, and masks were not worn in 22 situations (92%). New source of infection has not been identified. In situations with a high known risk of infection, many cases were related to eating and drinking, and insufficient use of masks was evident. Raising risk awareness on infection prevention and control of COVID-19 is urgently needed.

10 0 0 0 OA COVID-19 can suddenly become severe: a case series from Tokyo, Japan

著者: Keiji Nakamura Satoshi Ide Sho Saito Noriko Kinoshita Satoshi Kutsuna Yuki Moriyama Tetsuya Suzuki Masayuki Ota Hidetoshi Nomoto Tetsuya Mizoue Masayuki Hojo Jin Takasaki Yusuke Asai Mari Terada Yutaro Akiyama Yusuke Miyazato Takato Nakamoto Yuji Wakimoto Mugen Ujiie Kei Yamamoto Masahiro Ishikane Shinichiro Morioka Kayoko Hayakawa Haruhito Sugiyama Norio Ohmagari
出版者: National Center for Global Health and Medicine
雑誌: Global Health & Medicine (ISSN:24349186)
巻号頁・発行日: vol.2, no.3, pp.174-177, 2020-06-30 (Released:2020-07-04)
参考文献数: 8
被引用文献数: 7

Since the initial report of coronavirus disease (COVID-19) from the City of Wuhan, China in December 2019, there have been multiple cases globally. Reported here are 11 cases of COVID-19 at this hospital; all of the patients in question presented with relative bradycardia. The severity of the disease was classified into four grades. Of the patients studied, 3 with mild COVID-19 and 3 with moderate COVID-19 improved spontaneously. Lopinavir/ritonavir was administered to 3 patients with severe COVID-19 and 2 with critical COVID-19. Both patients with critical COVID-19 required mechanical ventilation and extracorporeal membrane oxygenation. Both patients with critical COVID-19 had a higher fever that persisted for longer than patients with milder COVID-19. The respiratory status of patients with critical COVID-19 worsened rapidly 7 days after the onset of symptoms. Relative bradycardia may be useful in distinguishing between COVID-19 and bacterial community-acquired pneumonia. In patients who have had a fever for > 7 days, the condition might worsen suddenly.

2022-01-20 20:31:39
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6 0 0 0 OA A new challenge of unfractionated heparin anticoagulation treatment for moderate to severe COVID-19 in Japan

著者: Rubuna Sato Masahiro Ishikane Noriko Kinoshita Tetsuya Suzuki Takato Nakamoto Kayoko Hayakawa Norifumi Bekki Hisao Hara Norio Ohmagari
出版者: National Center for Global Health and Medicine
雑誌: Global Health & Medicine (ISSN:24349186)
巻号頁・発行日: pp.2020.01044, (Released:2020-05-15)
参考文献数: 13
被引用文献数: 14

Hypercoagulation and anticoagulation treatment have become new challenges in coronavirus disease 2019 (COVID-19) patients during the COVID-19 pandemic. We herein suggest an algorithm for an anticoagulation treatment with unfractionated heparin in moderate to severe COVID-19 cases in Japan, and report a case of COVID-19 pneumonia with anticoagulation treatment. Although several promising drugs for COVID-19 are being tested in clinical trials, definitive treatments have not yet been established. In this report, we demaonstrate that anticoagulation treatment with unfractionated heparin has the possibility of becoming at least a supportive treatment for COVID-19 patients.

2020-06-23 12:31:58
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5 0 0 0 OA SARS-CoV-2 infection among returnees on charter flights to Japan from Hubei, China: a report from National Center for Global Health and Medicine

著者: Kayoko Hayakawa Satoshi Kutsuna Takeo Kawamata Yuko Sugiki Chiharu Nonaka Keiko Tanaka Michi Shoji Masaki Nagai Shunsuke Tezuka Kazuyuki Shinya Hiroki Saito Takahiro Harada Nin Moriya Motoyuki Tsuboi Masataro Norizuki Yasuo Sugiura Yasuyo Osanai Masaya Sugiyama Ayako Okuhama Kohei Kanda Yuji Wakimoto Mugen Ujiie Shinichiro Morioka Kei Yamamoto Noriko Kinoshita Masahiro Ishikane Sho Saito Yuki Moriyama Masayuki Ota Keiji Nakamura Takato Nakamoto Satoshi Ide Hidetoshi Nomoto Yutaro Akiyama Tetsuya Suzuki Yusuke Miyazato Yoshiaki Gu Nobuaki Matsunaga Shinya Tsuzuki Yumiko Fujitomo Yoshiki Kusama Hiroyuki Shichino Masao Kaneshige Junko Yamanaka Miki Saito Masayuki Hojo Masao Hashimoto Shinyu Izumi Jin Takasaki Manabu Suzuki Keita Sakamoto Yukio Hiroi Sakurako Emoto Makoto Tokuhara Toshiaki Kobayashi Koichiro Tomiyama Fumihiko Nakamura Norio Ohmagari Haruhito Sugiyama
出版者: National Center for Global Health and Medicine
雑誌: Global Health & Medicine (ISSN:24349186)
巻号頁・発行日: vol.2, no.2, pp.107-111, 2020-04-30 (Released:2020-05-10)
参考文献数: 11
被引用文献数: 25

Due to the significant spread of a new type of coronavirus (SARS-CoV-2) infection (COVID-19) in China, the Chinese government blockaded several cities in Hubei Province. Japanese citizens lost a means of transportation to return back to Japan. The National Center for Global Health and Medicine (NCGM) helped the operation of charter flights for evacuation of Japanese residents from Hubei Province, and this article outlines our experiences. A total of five charter flights were dispatched, and the majority of returnees (793/829 [95.7%]) were handled at NCGM. A large number of personnel from various departments participated in this operation; 107 physicians, 115 nurses, 110 clerical staff, and 45 laboratory technicians in total. Several medical translators were also involved. In this operation, we conducted airborne precautions in addition to contact precautions. Eye shields were also used. The doctors collecting the pharyngeal swab used a coverall to minimize the risk of body surface contamination from secretions and droplets. Enhanced hand hygiene using alcohol hand sanitizer was performed. Forty-eight persons were ultimately hospitalized after the triage at NCGM operation, which was more than the number of persons triaged at the airport (n = 34). Of those hospitalized after NCGM triage, 8.3% (4/48 patients) ultimately tested positive for SARS-CoV-2, significantly higher than the positive rate among subjects not triaged (4/48 [8.3%] vs. 9/745 [1.2%]: p = 0.0057). NCGM participated in a large-scale operation to evacuate Japanese nationals from the COVID-19 epidemic area. We were able to establish a scheme through this experience that can be used in the future.

2022-01-20 20:31:41
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4 0 0 0 OA A novel protocol for de-isolating moderately and severely immunocompromised COVID-19 patients

著者: Kohei Kamegai Noriko Iwamoto Masahiro Ishikane Kei Yamamoto Kumi Horii Shiho Kubota Akira Hangaishi Hiroshi Shimazu Tomiteru Togano Hiroyuki Yamashita Yasuhide Yamada Norio Ohmagari
出版者: National Center for Global Health and Medicine
雑誌: Global Health & Medicine (ISSN:24349186)
巻号頁・発行日: pp.2023.01053, (Released:2023-11-15)
参考文献数: 27

Immunocompromised coronavirus disease 2019 patients are at a higher risk of prolonged viral shedding than immunocompetent patients. However, as of August 2023, there is no clear international standard for de-isolating vulnerable patients. A comprehensive assessment is advisable based on various information, such as the increase in immune escape of specific mutant strains as well as the patient's innate immunity and vaccination status; therefore, consultation with an infectious disease specialist is recommended. The patient population defined as moderately or severely immunocompromised by the Centers for Disease Control and Prevention and the European Centre for Disease Prevention and Control is significantly broad. A boundary between the two remains to be delineated, and the existing protocols allow the release of patients based on their symptoms alone. This may lead to an unnecessary extension or premature termination of isolation. In this study, we searched for studies, particularly those that used real-world data, discussed the results with experts in our hospital, and proposed new isolation criteria based on both testing and clinical symptoms. We classified patients into three groups namely severely, moderately, and mildly immunocompromised, defined by their background and the administration of immunosuppressive drugs. A separate flowchart for ending isolation is indicated for each group. This standard may be a useful support material, especially for non-specialists. Nevertheless, our criteria must be revised and added continuously; accumulating real-world data to support revision of and addition to the list is becoming increasingly important.

2023-11-15 22:59:36
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3 0 0 0 OA A Case of COVID-19 Patient with False-negative for SARS-CoV-2 of Pharyngeal Swab, from a Chinese traveller Returning from Wuhan, Hubei Province, China, January 2020

著者: Masahiro Ishikane Yusuke Miyazato Satoshi Kustuna Tetsuya Suzuki Satoshi Ide Keiji Nakamura Shinichiro Morioka Harutaka Katano Tadaki Suzuki Norio Ohmagari
出版者: National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
雑誌: Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日: pp.JJID.2020.240, (Released:2020-05-29)
参考文献数: 14
被引用文献数: 1

We report a case of patient in Japan with Coronavirus disease 2019 (COVID-19) with false-negative of reverse transcription polymerase chain reaction for Severe Acute Respiratory Syndrome Coronavirus 2 of pharyngeal swab, from a Chinese traveller returning from Wuhan, Hubei Province, China. If a patient is clinically or epidemiologically suspected of COVID-19, appropriate infection and prevention control measures such as standard, contact, and droplet precaution are needed until the patient is proven to be true-negative.

2021-10-13 09:26:54
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3 0 0 0 OA Non-COVID-19 Patients with Life-threatening Diseases Who Visited a Fever Clinic: A Single-Center, Observational Study in Tokyo, Japan

著者: Yutaro Akiyama Shinichiro Morioka Yuji Wakimoto Akira Kawashima Kohei Kanda Ayako Okuhama Tetsuya Suzuki Yusuke Miyazato Hidetoshi Nomoto Satoshi Ide Takato Nakamoto Keiji Nakamura Masayuki Ota Yuki Moriyama Saho Takaya Kota Yamada Maho Taguchi Erika Sugito Shinji Izuka Kenji Ishiguro Toshiaki Kobayashi Wataru Miyake Shuji Kubota Masahiro Ishikane Noriko Kinoshita Kei Yamamoto Mugen Ujiie Satoshi Kutsuna Kayoko Hayakawa Sho Saito Norio Ohmagari
出版者: The Japanese Society of Internal Medicine
雑誌: Internal Medicine (ISSN:09182918)
巻号頁・発行日: pp.5614-20, (Released:2020-11-02)
参考文献数: 7
被引用文献数: 2

Objective In fever clinics screening coronavirus disease (COVID-19), there could be patients with life-threatening diseases that physicians should not overlook. We exploratorily investigated the final diagnosis among non-COVID-19 hospitalized patients who visited the fever clinic. Methods This was a retrospective, observational, and single-centered study conducted in the National Center for Global Health and Medicine (NCGM), Tokyo, Japan. We conducted a retrospective chart review of patients who visited the fever clinic in the NCGM from 11 March 2020 to 24 April 2020. Patients Patients who met the following clinical criteria visited the fever clinic in the NCGM: (1) body temperature >37.5°C, (2) any symptoms consistent with COVID-19 or (3) referral from local healthcare facilities. In the fever clinic, all patients who met the above criteria had severe acute respiratory syndrome coronavirus 2 polymerase chain reaction test with nasopharyngeal swab specimens. Patients with severe symptoms or an unstable condition were sent to an outpatient clinic for infectious diseases for further evaluation and treatment. Results Among 1,470 patients who visited the fever clinic, 84 patients were hospitalized, and 45 of them were diagnosed as having COVID-19. Among the remaining 39 non-COVID-19 patients, there were nine patients with life-threatening diseases. The life-threatening diseases included acute heart failure, septic shock, pneumocystis pneumonia, peritonsillar abscess, and necrotizing fasciitis. Conclusion Physicians should evaluate each patient carefully while considering other life-threatening conditions even in such a COVID-19 pandemic era.

2020-11-06 07:02:23
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2 0 0 0 OA SARS-CoV-2 infection among returnees on charter flights to Japan from Hubei, China: a report from National Center for Global Health and Medicine

著者: Kayoko Hayakawa Satoshi Kutsuna Takeo Kawamata Yuko Sugiki Chiharu Nonaka Keiko Tanaka Michi Shoji Masaki Nagai Shunsuke Tezuka Kazuyuki Shinya Hiroki Saito Takahiro Harada Nin Moriya Motoyuki Tsuboi Masataro Norizuki Yasuo Sugiura Yasuyo Osanai Masaya Sugiyama Ayako Okuhama Kohei Kanda Yuji Wakimoto Mugen Ujiie Shinichiro Morioka Kei Yamamoto Noriko Kinoshita Masahiro Ishikane Sho Saito Yuki Moriyama Masayuki Ota Keiji Nakamura Takato Nakamoto Satoshi Ide Hidetoshi Nomoto Yutaro Akiyama Tetsuya Suzuki Yusuke Miyazato Yoshiaki Gu Nobuaki Matsunaga Shinya Tsuzuki Yumiko Fujitomo Yoshiki Kusama Hiroyuki Shichino Masao Kaneshige Junko Yamanaka Miki Saito Masayuki Hojo Masao Hashimoto Shinyu Izumi Jin Takasaki Manabu Suzuki Keita Sakamoto Yukio Hiroi Sakurako Emoto Makoto Tokuhara Toshiaki Kobayashi Koichiro Tomiyama Fumihiko Nakamura Norio Ohmagari Haruhito Sugiyama
出版者: National Center for Global Health and Medicine
雑誌: Global Health & Medicine (ISSN:24349186)
巻号頁・発行日: pp.2020.01036, (Released:2020-04-29)
参考文献数: 11
被引用文献数: 25

2020-05-04 10:57:25
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2 0 0 0 OA Epidemiology of antimicrobial use among nursing homes in Japan, 2016: A pilot study

著者: Masahiro Ishikane Yoshiki Kusama Chika Tanaka Kayoko Hayakawa Takeshi Kuwahara Norio Ohmagari
出版者: National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
雑誌: Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日: pp.JJID.2019.476, (Released:2020-01-31)
参考文献数: 11
被引用文献数: 3

Antimicrobial resistance (AMR) is an emerging problem in both acute care hospitals and nursing homes. From January to December 2016, we conducted a pilot, descriptive epidemiological study to examine antimicrobial use (AMU) among six nursing homes in Tokyo, Japan. AMU was extracted from prescription data of a pharmacy that received all prescriptions from the nursing homes. To standardize the comparison of drug usage, AMU was measured using defined daily dose (DDD) and described as DDDs/1,000 resident-days. The overall AMU was 15.3/1,000 resident-days including oral-antimicrobials (15.2/1,000 resident-days [99.3%]). The most frequently prescribed oral-antimicrobials was macrolides (5.8/1,000 resident-days [38.2%]) and quinolones (4.2/1,000 resident-days [27.6%]). Oral-macrolides and quinolones were thought to be convenience in prescription among nursing homes with resource limiting due to smaller defined the number of daily doses compared to penicillins and cephalosporins. Further multi-center studies that include residents-specific data (demographics and diagnosis), and focusing on purpose of antimicrobials (treatment or prevention) are needed to evaluate the appropriateness of antimicrobials.

2020-02-01 12:36:08
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1 0 0 0 OA Necessity for a System Implementing Therapeutic Drug Monitoring in Outpatient Settings Based on the Actual Use of Voriconazole Using the National Database of Health Insurance Claims and Specific Health Checkups of Japan: A Descriptive Epidemiological Study

著者: Yuichi Muraki Ryuji Koizumi Yoshiki Kusama Ryo Inose Masahiro Ishikane Norio Ohmagari
出版者: The Pharmaceutical Society of Japan
雑誌: Biological and Pharmaceutical Bulletin (ISSN:09186158)
巻号頁・発行日: vol.46, no.10, pp.1490-1493, 2023-10-01 (Released:2023-10-01)
参考文献数: 14

Voriconazole (VRCZ) is an antifungal drug that necessitates therapeutic monitoring (TDM). Typically, TDM is recommended for patients undergoing long-term outpatient treatment. However, in Japan, insurance reimbursement for TDM is only permitted for inpatients. There is a concern that VRCZ use is growing among outpatients, although information regarding this issue remains unavailable. Therefore, we aimed to clarify the use of VRCZ by utilizing data from the National Database of Health Insurance Claims and Specific Health Checkups in Japan. The use of branded and generic oral VRCZ from 2013 to 2019 was calculated using the defined daily doses/1000 inhabitants/d (DID) for each receipt type. Oral VRCZ was used more frequently in the outpatient setting than that in the inpatient setting, with use increasing over time. The use of generic drugs began in 2016 and accounted for 52.5% of the use in 2019 among outpatients. Considering outpatient prescriptions, 76.4–81.0% were dispensed at insurance pharmacies, indicating the need for community pharmacist involvement. Accordingly, the appropriate use of VRCZ in ambulatory care should be promoted in collaboration with community pharmacists, and a reimbursement system should be established to implement TDM in ambulatory care.

2023-10-01 12:46:29
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1 0 0 0 OA The Use of Topical Antibiotics Based on the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB) Open Data in 2017

著者: Tomoko Nakanishi Ryo Inose Yoshiki Kusama Masahiro Ishikane Toshiki Kajihara Koji Yahara Motoyuki Sugai Hiroki Ohge Norio Ohmagari Yuichi Muraki
出版者: National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
雑誌: Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日: vol.75, no.2, pp.177-182, 2022-03-31 (Released:2022-03-24)
参考文献数: 31
被引用文献数: 3

The national action plan on antimicrobial resistance (AMR) in Japan emphasizes the importance of understanding antimicrobial use (AMU). Some studies have been conducted on oral and parenteral AMU in Japan. However, there are few studies on the use of topical antimicrobials, such as in dermatology and ophthalmology. Therefore, the purpose of this study was to investigate the use of topical AMU in Japan. Data on AMU in dermatology and ophthalmology were obtained from the 2017 National Database of Health Insurance Claims and Specific Health Checkups of Japan Open Data. The number of dermatological products used was 58,396,530 in 2017. The proportions of betamethasone/gentamicin and gentamicin used were 50.5% and 16.7%, respectively, whereas that of the ingredient quantity in gentamicin was 7.8%. It has been suggested that topical AMU should be evaluated based on the number of products being used. The number of ophthalmological products used was 24,655,653 in 2017, and the proportion of quinolones used was 95.9%. The high prescription rate of quinolones may cause an increase in quinolone resistance in the ophthalmologic field. Topical AMU, which is a potential “blind spot” in the measures against AMR, needs to be continuously monitored, together with systemic AMU.

2022-03-24 20:14:21
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1 0 0 0 OA Trends in Antipseudomonal Agent Use Based on the 2006 to 2015 Sales Data in Japan

著者: Ai Ebisui Ryo Inose Yoshiki Kusama Ryuji Koizumi Ayako Kawabe Saki Ishii Ryota Goto Masahiro Ishikane Tetsuya Yagi Norio Ohmagari Yuichi Muraki
出版者: The Pharmaceutical Society of Japan
雑誌: Biological and Pharmaceutical Bulletin (ISSN:09186158)
巻号頁・発行日: vol.44, no.6, pp.816-821, 2021-06-01 (Released:2021-06-01)
参考文献数: 25
被引用文献数: 1

Pseudomonas aeruginosa resistance is a major issue worldwide. Drug resistance is related to inappropriate antibiotic use. Because antipseudomonal agents have a wide spectrum, they must be used appropriately. The purpose of this study was to clarify the trends in antipseudomonal agent use in Japan based on sales data from 2006 to 2015. The total antipseudomonal agent use was increased significantly (r = 0.10, Pfor trend = 0.00040). The proportion of fluoroquinolones use was the highest throughout the year, accounting for 88.6–91.4%. The use of piperacillin/tazobactam significantly increased. The increased use of these drugs may be due to the launch of higher doses and additional indications. On the other hand, for antipseudomonal agents, parenteral carbapenems use was 2.7–3.7%, but it has remained unchanged over the years. In Japan, permit and notification systems have been introduced to prevent the inappropriate use of parenteral carbapenems in medical institutions. It was speculated that these efforts suppressed the inappropriate use of parenteral carbapenems. This study clarified the trend of antipseudomonal agent use in Japan from 2006 to 2015. It is important to continue monitoring antipseudomonal agents use to conduct appropriate antimicrobial resistance measures.

2021-11-15 20:14:48
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1 0 0 0 OA A new challenge of unfractionated heparin anticoagulation treatment for moderate to severe COVID-19 in Japan

著者: Rubuna Sato Masahiro Ishikane Noriko Kinoshita Tetsuya Suzuki Takato Nakamoto Kayoko Hayakawa Norifumi Bekki Hisao Hara Norio Ohmagari
出版者: National Center for Global Health and Medicine
雑誌: Global Health & Medicine (ISSN:24349186)
巻号頁・発行日: vol.2, no.3, pp.190-192, 2020-06-30 (Released:2020-07-04)
参考文献数: 13
被引用文献数: 1 14

2021-05-31 02:40:12
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1 0 0 0 OA Trends of the Use of Anti-methicillin-Resistant Staphylococcus aureus Agents in Japan Based on Sales Data from 2006 to 2015

著者: Ryota Goto Ryo Inose Yoshiki Kusama Ayako Kawabe Saki Ishii Ai Ebisui Masahiro Ishikane Tetsuya Yagi Norio Ohmagari Yuichi Muraki
出版者: The Pharmaceutical Society of Japan
雑誌: Biological and Pharmaceutical Bulletin (ISSN:09186158)
巻号頁・発行日: vol.43, no.12, pp.1906-1910, 2020-12-01 (Released:2020-12-01)
参考文献数: 15
被引用文献数: 11

Patterns of the use of anti-methicillin-resistant Staphylococcus aureus (MRSA) agents in Japan might be influenced by the launch of new anti-MRSA agents, the publication of relevant guidelines, and the increase in the number of generic medicines. However, as anti-MRSA agents are included in multiple anatomical therapeutic chemical classifications, such as glycopeptides and aminoglycosides, the trends of the use of individual anti-MRSA agents remain unclear. Here, we aimed to clarify the trends of anti-MRSA agent use in Japan from 2006 to 2015 based on sales data. Total anti-MRSA agent use was found to have significantly increased from 2006 to 2015 (Pfor trend = 0.027, r = 0.00022). Individual trends for vancomycin (VCM), daptomycin, and linezolid (LZD) use showed significant increases, while those for arbekacin (ABK) and teicoplanin (TEIC) showed decreases. In addition, oral LZD use significantly increased, while there was no significant change in intravenous LZD use. The ratio of oral LZD use to total LZD use increased from 25.5% in 2006 to 39.9% in 2015. Meanwhile, TEIC and ABK use decreased, while VCM use increased, following the launch of generic medicines. These results might reflect the status of guideline compliance, the launch of new anti-MRSA agents, and the decline in the sales promotion of the original medicines. It is extremely important to investigate trends for the use of not only different antibiotic groups but also individual antibiotics to develop and implement antimicrobial resistance countermeasures.

2020-12-06 08:24:22
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