- 著者
- Nobuaki Suzuki Tatsuru Yokoi Takahiro Kimura Yoshiyuki Ikeda Shinji Takahashi Takashi Aoyagi Yoshitaka Shiratori Noriyuki Hayami Ken Kozuma
- 出版者
- The Japanese Circulation Society
- 雑誌
- Circulation Journal (ISSN:13469843)
- 巻号頁・発行日
- pp.CJ-23-0266, (Released:2023-10-12)
- 参考文献数
- 29
- 被引用文献数
- 1
Background: The slow-flow phenomenon is associated with worse clinical outcomes after percutaneous coronary intervention (PCI), so our goal for this study was to see how predictive how near-infrared spectroscopy (NIRS) could be.Methods and Results: We enrolled 179 lesions from 152 patients who had de novo coronary stent implantation guided by NIRS-intravascular ultrasound (IVUS) (male: 69.1%, mean age: 74.3±11.5 years, acute coronary syndrome: 65.1%, diabetes: 42.1%). NIRS automatically determined the maximum 4-mm lipid core burden index (maxLCBI4 mm) value at pre- and post-PCI procedures. The slow-flow phenomenon was defined as the deterioration of TIMI (Thrombolysis in Myocardial Infarction) flows on angiography during the PCI procedure in the absence of mechanical obstruction. The slow-flow phenomenon occurred in 13 (7.3%) lesions, and the slow-flow phenomenon group had a significantly higher maxLCBI4 mm(740±147 vs. 471±223, P<0.001). The best maxLCBI4 mmcutoff point in both acute and chronic coronary syndrome was 578 and 480, with sensitivity of 100%, for predicting the slow-flow phenomenon. In the receiver-operating characteristics analysis, the area under the curve for acute and chronic coronary syndrome was 0.849 and 0.851, respectively.Conclusions: The results of this study support the utility of NIRS-IVUS-guided PCI for the prediction of the slow-flow phenomenon.
- 著者
- Takashi Kitabatake Shinji Takahashi
- 出版者
- Tohoku University Medical Press
- 雑誌
- The Tohoku Journal of Experimental Medicine (ISSN:00408727)
- 巻号頁・発行日
- vol.94, no.1, pp.37-43, 1968 (Released:2008-11-28)
- 参考文献数
- 14
- 被引用文献数
- 1 3
A linear accelerator applied to conformation radiotherapy was described. The mechanism and dose distribution in the linear accelerator conformation radiotherapy were discussed, together with a comparison with those in telecobalt therapy. In this machine a collimator was divided into six leaves, which were driven independently by a servo system following signals given by the signal generator. The mechanical error in this system was within a range of +1.47 to-1.80%. The size and shape of radiation-dense area, ‘beam focus’, made by this unit sufficiently coincided geometrically with the region of planned treat-ments. The homogeneity of dose distribution was better than that by telecobalt gamma-rays.
- 著者
- Ryo Kamata Fujio Shiraishi Shinji Takahashi Akira Shimizu Daisuke Nakajima Shiho Kageyama Takushi Sasaki Kyosuke Temma
- 出版者
- 日本毒性学会
- 雑誌
- The Journal of Toxicological Sciences (ISSN:03881350)
- 巻号頁・発行日
- vol.38, no.6, pp.903-912, 2013-12-01 (Released:2013-11-09)
- 参考文献数
- 27
- 被引用文献数
- 7
In the 1950s to 1970s developed countries reported declines in populations of raptorial and fish-eating birds and dichlorodiphenyltrichloroethane (DDT) and its metabolites were considered causative substances because they accumulated significantly in the tissues of wild birds and animals. However, except for the estrogenic effects of o,p’-DDT, a minor component of commercial DDT, there has been no compelling evidence that DDT directly affects avian reproductive systems. To assess the possible impact of DDT on development and reproduction of birds, exposure experiments to the major component of commercial DDT, p,p’-DDT, and its persistent metabolite, p,p’-dichlorodiphenyldichloroethylene (DDE), were performed using Japanese quail (Coturnix japonica) eggs; the test substances (3 to 100 μg/g) were injected into the yolk prior to incubation, and hatched chicks were raised to adulthood. p,p’-DDT had no significant effects on the morphology and function of the reproductive systems, although the hatchability of treated eggs was reduced at the highest dose (100 μg/g). High doses of p,p’-DDE slightly enhanced the eggshell forming ability of female quails; eggshell mass and thickness were increased at 30 μg/g or more although no morphological changes were observed in the oviduct. Transcriptions of the CYP11A1 gene in the ovaries, and of AHR and ARNT in the livers, of adult females were significantly increased at 3 μg/g or more of p,p’-DDT. Except for low hatchability, transovarian exposure to p,p’-DDT or p,p’-DDE did not markedly impair the avian reproductive systems, but the hormonal actions of these compounds are likely to change reproductive and hepatic functions even after maturation.