著者

Hiroaki Kawase Akihiko Murata Ken Yamada Tosiyuki Nakaegawa Rui Ito Ryo Mizuta Masaya Nosaka Shunichi Watanabe Hidetaka Sasaki

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

pp.2021-001, (Released:2020-12-18)

被引用文献数

12

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We investigate regional characteristics of future changes in snowfall in Japan under two emission scenarios—RCP2.6 and RCP8.5—using a high-resolution regional climate model with 5 km grid spacing and discuss the influence of changes in atmospheric circulation. The high-resolution model can simulate details of changes in distributions of total snowfall in Japan. Under RCP2.6, the annual total snowfall decreases in most parts of Japan except for Japan's northern island, Hokkaido. In Hokkaido, the winter snowfall increases even under RCP8.5, especially in January and February. The snowfall peak is delayed from early December to late January in Hokkaido. Along the Sea of Japan in eastern Japan, the winter-total snowfall decreases even if the winter mean temperature is below 0°C in the future climate. The different snowfall changes in Hokkaido and on the Sea of Japan side of eastern Japan are caused by precipitation changes in each region. Future changes in atmospheric circulation related to the Aleutian low cause the enhancement and the inhibition of winter precipitation in Hokkaido and the Sea of Japan side of eastern Japan, respectively, contributing to changes in the regional characteristics of snowfall and snow cover in addition to moistening due to atmospheric and ocean warming.

著者

Hiroaki Kawase Akihiko Murata Ken Yamada Tosiyuki Nakaegawa Rui Ito Ryo Mizuta Masaya Nosaka Shunichi Watanabe Hidetaka Sasaki

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

vol.17, pp.1-7, 2021 (Released:2021-01-27)

参考文献数

29

被引用文献数

12

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We investigate regional characteristics of future changes in snowfall in Japan under two emission scenarios—RCP2.6 and RCP8.5—using a high-resolution regional climate model with 5km grid spacing and discuss the influence of changes in atmospheric circulation. The high-resolution model can simulate details of changes in distributions of total snowfall in Japan. Under RCP2.6, the annual total snowfall decreases in most parts of Japan except for Japan's northern island, Hokkaido. In Hokkaido, the winter snowfall increases even under RCP8.5, especially in January and February. The snowfall peak is delayed from early December to late January in Hokkaido. Along the Sea of Japan in eastern Japan, the winter-total snowfall decreases even if the winter mean temperature is below 0°C in the future climate. The different snowfall changes in Hokkaido and on the Sea of Japan side of eastern Japan are caused by precipitation changes in each region. Future changes in atmospheric circulation related to the Aleutian low cause the enhancement and the inhibition of winter precipitation in Hokkaido and the Sea of Japan side of eastern Japan, respectively, contributing to changes in the regional characteristics of snowfall and snow cover in addition to moistening due to atmospheric and ocean warming.

著者

Tharanga MR RAMANAYAKE MUDIYANSELAGE Daisuke FUJIWARA Masataka MICHIGAMI Shunichi WATANABE Zhengmao YE Atsuko UYEDA Ryoji KANEGI Shingo HATOYA Ikuo FUJII Kikuya SUGIURA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.21-0318, (Released:2022-06-24)

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Blocking the interaction between CD28 and B7 by cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a potent immune checkpoint that prevents damage to host tissues from excessive immune responses. However, it also significantly diminishes immune responses against cancers and allows cancer cell growth. This study found that recombinant (r) human (h) CTLA-4 specifically binds to canine dendritic cells (DCs) and suppresses the responses of canine T cells to allogeneic DCs. ERY2-4, a peptide targeting rhCTLA-4 selected from a yeast-displayed library of helix-loop-helix (HLH) peptides and improved to have a binding affinity to rhCTLA-4 as strong as that of rhB7, inhibited the binding of rhCTLA-4 to canine DCs. Furthermore, the targeting peptide significantly enhanced the response of canine T cells to allogeneic DCs. These results suggest that the CTLA-4-targeting peptide enhances canine T cell activity by blocking the interaction between canine CTLA-4 on T cells and canine B7 on DCs. This study demonstrates the generation of a new type of immune checkpoint inhibitor, which may be applicable to cancer therapy in dogs.