著者
Ha T. T. Duong Hirofumi Suzuki Saki Katagiri Mayu Shibata Misae Arai Kei Yura
出版者
The Biophysical Society of Japan
雑誌
Biophysics and Physicobiology (ISSN:21894779)
巻号頁・発行日
vol.19, pp.e190025, 2022 (Released:2022-08-20)
参考文献数
46

Sequencing of individual human genomes enables studying relationship among nucleotide variations, amino acid substitutions, effect on protein structures and diseases. Many studies have found general tendencies, for instance, that pathogenic variations tend to be found in the buried regions of the protein structures, that benign variations tend to be found on the surface of the proteins, and that variations on evolutionary conserved residues tend to be pathogenic. These tendencies were deduced from globular proteins with standard evolutionary changes in amino acid sequences. In this study, we investigated the variation distribution on actin, one of the highly conserved proteins. Many nucleotide variations and three-dimensional structures of actin have been registered in databases. By combining those data, we found that variations buried inside the protein were rather benign and variations on the surface of the protein were pathogenic. This idiosyncratic distribution of the variation impact is likely ascribed to the extensive use of the surface of the protein for protein-protein interactions in actin.
著者
Ngoc B. Nguyen Nguyet T. M. Nguyen Nhai T. Nguyen Linh H. Le Nghia T. La Thuy T. T. Nguyen Mary Jeany Yanoria Nagao Hayashi Hiroki Saito Mitsuhiro Obara Tadashi Sato Yoshimichi Fukuta
出版者
Japanese Society of Breeding
雑誌
Breeding Science (ISSN:13447610)
巻号頁・発行日
vol.73, no.2, pp.193-203, 2023 (Released:2023-06-06)
参考文献数
40

A unique genetic variation with respect to blast resistance was clarified in 201 rice accessions from Vietnam. These accessions were classified into three clusters—A, B1, and B2—based on their reactions to 26 standard differential blast isolates selected in Vietnam. Cluster A was the dominant cultivar group in Vietnam and the most susceptible of the three clusters. Cluster B1 was the smallest group and the most resistant. Cluster B2 was the second-most dominant group and of intermediate resistance between clusters A and B1. The percentages of accessions comprising each cluster varied by region and area. Accessions in cluster A were distributed widely throughout Vietnam and had the highest frequencies in both the Central and North regions. Accessions in cluster B2 were found with highest frequencies in the mountainous and intermediate areas of the North region. Accessions in cluster B1 were found with highest frequencies in the Central region and Red River Delta area (North region). These results suggest that rice accessions in Vietnam were basically susceptible (cluster A) or of intermediate resistance (cluster B2), and that high-resistance cultivars were mainly distributed in the low altitude areas, such as the Red River Delta area and Central region.
著者
T.  T. Giang Tran Karen Farquharson Deborah Dempsey
出版者
Center for Southeast Asian Studies, Kyoto University
雑誌
Southeast Asian Studies (ISSN:21867275)
巻号頁・発行日
vol.11, no.3, pp.339-362, 2022-12-22 (Released:2022-12-22)
参考文献数
62

Son preference has traditionally been a fundamental cultural value in Vietnamese families, and this preference appears to have intensified in Vietnam in recent years. The key explanation for why parents prefer sons to daughters is that Vietnamese families embrace Confucian notions of gender hierarchy. Based on in-depth interviews with twenty first-generation Vietnamese migrant parents from refugee and skilled migrant backgrounds, and 18 Vietnamese Australian children of migrant parents, this paper explores whether Vietnamese migrants to Australia and their children display a preference for sons in their families. The findings suggest that sons are no longer valued in the ways that they were in Vietnam. Many parents in this study did not express a need to live with, receive financial support from, or be cared for by their sons. The children also expressed fewer financial support and caring obligations to parents. We propose that the greater financial security afforded to the elderly by the social welfare system in Australia may decrease parents’ dependence on sons, lowering the value of sons in families. This strongly suggests that the economic value of sons is key to the persistence of son preference in Vietnam, more so than Confucian notions of gender hierarchy.