著者

Aina Fukuda Souichi Nakashima Yoshimi Oda Kaneyasu Nishimura Hidekazu Kawashima Hiroyuki Kimura Takashi Ohgita Eri Kawashita Keiichi Ishihara Aoi Hanaki Mizuki Okazaki Erika Matsuda Yui Tanaka Seikou Nakamura Takahiro Matsumoto Satoshi Akiba Hiroyuki Saito Hisashi Matsuda Kazuyuki Takata

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.46, no.2, pp.320-333, 2023-02-01 (Released:2023-02-01)

参考文献数

69

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Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by dementia. The most characteristic pathological changes in AD brain include extracellular amyloid-β (Aβ) accumulation and neuronal loss. Particularly, cholinergic neurons in the nucleus basalis of Meynert are some of the first neuronal groups to degenerate; accumulating evidence suggests that Aβ oligomers are the primary form of neurotoxicity. Bacopa monniera is a traditional Indian memory enhancer whose extract has shown neuroprotective and Aβ-reducing effects. In this study, we explored the low molecular weight compounds from B. monniera extracts with an affinity to Aβ aggregates, including its oligomers, using Aβ oligomer-conjugated beads and identified plantainoside B. Plantainoside B exhibited evident neuroprotective effects by preventing Aβ attachment on the cell surface of human induced pluripotent stem cell (hiPSC)-derived cholinergic neurons. Moreover, it attenuated memory impairment in mice that received intrahippocampal Aβ injections. Furthermore, radioisotope experiments revealed that plantainoside B has affinity to Aβ aggregates including its oligomers and brain tissue from a mouse model of Aβ pathology. In addition, plantainoside B could delay the Aβ aggregation rate. Accordingly, plantainoside B may exert neuroprotective effects by binding to Aβ oligomers, thus interrupting the binding of Aβ oligomers to the cell surface. This suggests its potential application as a theranostics in AD, simultaneously diagnostic and therapeutic drugs.

著者

Koji Yoshimoto Takeshi Yatabe Takahiro Matsumoto Andrew Robertson Hidetaka Nakai Hiromasa Tanaka Takashi Kamachi Yoshihito Shiota Kazunari Yoshizawa Koichiro Asazawa Hirohisa Tanaka Seiji Ogo

出版者

(社)日本化学会

雑誌

Chemistry Letters (ISSN:03667022)

巻号頁・発行日

vol.45, no.2, pp.149-151, 2016-02-05 (Released:2016-02-05)

参考文献数

44

被引用文献数

4

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We report the first example of a µ-η1:η1-N2 dinuclear RuII complex with a polyamine ligand and elucidate the structure by means of X-ray analysis. The N≡N stretching vibration has been observed at 1994 cm−1 by Raman spectroscopy, which is the lowest value of all the known N2-coordinated RuII complexes. This low value strongly suggests the N≡N bond is primed for activation.

著者

Tomoko Ishida Mohammad Shahriar Khan Honami Kodama Yukiko Uejima Yumi Kawase Takahiro Matsumoto Yuki Yamamura Nobuyuki Sera Takao Gotou Masaaki Hirakawa Yoshitaka Yano Masayuki Shima Nobuyuki Yamagishi Keiji Wakabayashi Tetsushi Watanabe

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.43, no.9, pp.1361-1366, 2020-09-01 (Released:2020-09-01)

参考文献数

27

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We examined the association of biological components in airborne particles, i.e., proteins and endotoxins, in outdoor air with asthma exacerbation in the Fukuoka metropolitan area, Fukuoka, Japan. Data on emergency department (ED) visits for asthma in children (age, 0–14 years) and adults (age, 15–64 years) were collected at a medical center from December 2014 to November 2015. One hundred eighty-one children and 143 adults visited the ED for asthma, and the weekly number of ED visits in children increased in autumn, i.e., September (second week) to November (first week). Fine (aerodynamic diameter ≤2.5 µm) and coarse (≥2.5 µm) particles were collected for 3 or 4 weeks per month, and protein and endotoxin concentrations were analyzed. Protein was largely prevalent in fine particles (0.34–7.33 µg/m3), and concentrations were high in April, May, June, and October. In contrast, endotoxin was mainly included in coarse particles (0.0010–0.0246 EU/m3), and concentrations were high in September (third week), October (first, second, and fourth weeks), February (fourth week), and July (first week). The results of a Poisson regression analysis indicated that endotoxin (in fine and coarse particles alike) was a significant factor for ED visits related to asthma in children, even after adjusting for meteorological factors, i.e., temperature, relative humidity, and wind speed. However, there was no association between environmental factors and ED visits for asthma in adults. These results suggest that endotoxin in outdoor air is significantly associated with an increased risk of asthma exacerbation in children.

著者

Viet-Ha Tran Takeshi Yatabe Takahiro Matsumoto Hidetaka Nakai Kazuharu Suzuki Takao Enomoto Seiji Ogo

出版者

(社)日本化学会

雑誌

Chemistry Letters (ISSN:03667022)

巻号頁・発行日

vol.44, no.6, pp.794-796, 2015-06-05 (Released:2015-06-05)

参考文献数

37

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We report the first example of a Ni0 precursor that provides a contamination-free (<1%) nickel film by metal–organic chemical vapor deposition (MOCVD) using N2 as the carrier gas. The structure and physical properties of the Ni0 precursor and subsequent film are described.

著者

Takeshi Yatabe Takahiro Kikunaga Takahiro Matsumoto Hidetaka Nakai Ki-Seok Yoon Seiji Ogo

出版者

(社)日本化学会

雑誌

Chemistry Letters (ISSN:03667022)

巻号頁・発行日

vol.43, no.8, pp.1380-1382, 2014-08-05 (Released:2014-08-05)

参考文献数

22

被引用文献数

2

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We report the synthesis of mononuclear nonheme manganese(V)–oxo complexes in aqueous acetonitrile solution from the reaction of manganese(III) complexes using hydrogen peroxide as an oxidant for the first time. A crystal structure of chloro derivative of manganese(V)–oxo complex and its reactivity toward 3,5-di-tert-butyl-catechol are also reported.