- 著者
- Aina Fukuda Souichi Nakashima Yoshimi Oda Kaneyasu Nishimura Hidekazu Kawashima Hiroyuki Kimura Takashi Ohgita Eri Kawashita Keiichi Ishihara Aoi Hanaki Mizuki Okazaki Erika Matsuda Yui Tanaka Seikou Nakamura Takahiro Matsumoto Satoshi Akiba Hiroyuki Saito Hisashi Matsuda Kazuyuki Takata
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Biological and Pharmaceutical Bulletin (ISSN:09186158)
- 巻号頁・発行日
- vol.46, no.2, pp.320-333, 2023-02-01 (Released:2023-02-01)
- 参考文献数
- 69
Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by dementia. The most characteristic pathological changes in AD brain include extracellular amyloid-β (Aβ) accumulation and neuronal loss. Particularly, cholinergic neurons in the nucleus basalis of Meynert are some of the first neuronal groups to degenerate; accumulating evidence suggests that Aβ oligomers are the primary form of neurotoxicity. Bacopa monniera is a traditional Indian memory enhancer whose extract has shown neuroprotective and Aβ-reducing effects. In this study, we explored the low molecular weight compounds from B. monniera extracts with an affinity to Aβ aggregates, including its oligomers, using Aβ oligomer-conjugated beads and identified plantainoside B. Plantainoside B exhibited evident neuroprotective effects by preventing Aβ attachment on the cell surface of human induced pluripotent stem cell (hiPSC)-derived cholinergic neurons. Moreover, it attenuated memory impairment in mice that received intrahippocampal Aβ injections. Furthermore, radioisotope experiments revealed that plantainoside B has affinity to Aβ aggregates including its oligomers and brain tissue from a mouse model of Aβ pathology. In addition, plantainoside B could delay the Aβ aggregation rate. Accordingly, plantainoside B may exert neuroprotective effects by binding to Aβ oligomers, thus interrupting the binding of Aβ oligomers to the cell surface. This suggests its potential application as a theranostics in AD, simultaneously diagnostic and therapeutic drugs.
- 著者
- Yusaku MORITA Koji KANDABASHI Shigeyuki KAJIKI Hiroyuki SAITO Go MUTO Takahiro TABUCHI
- 出版者
- National Institute of Occupational Safety and Health
- 雑誌
- Industrial Health (ISSN:00198366)
- 巻号頁・発行日
- pp.2022-0012, (Released:2022-05-11)
- 被引用文献数
- 2
This study evaluated the relationship between occupational injuryrisk and gig work, which included the exchangeof labor for money between individuals or companies via digital platforms. AsJapan has experienced a severe economic decline during the coronavirus disease2019 (COVID-19) pandemic, an increasing number of individuals have engaged ingig work. While few studies have evaluated occupational risks in gig work, severaltraffic accidents associated with food delivery work have been reported in themass media. In this study, 18,317 individuals completed an internet survey thatcollected information pertaining to their involvement in gig work andexperience of related occupational injuries; data regarding several confounding factors were also recorded. Multiplelogistic regression analysis showed that workersinvolved in gig work had a greater risk of any minor occupational injuries(odds ratio, 3.40; 95% confidenceinterval, 2.81–4.11) and activity-limiting injuries (odds ratio, 8.37; 95% confidenceinterval, 6.47–10.82) than those not involved in gig work, after adjusting for age,sex, household income, lifestyle factors, and work-related factors. The resultsof this study indicate that gig workers are exposed to greater occupationalhazards during the COVID-19 pandemic. Additional studies are warranted toclarify the causal mechanism for this relationship.
- 著者
- Naoki Shitsukawa Chihiro Ikari Sanae Shimada Satoshi Kitagawa Koichi Sakamoto Hiroyuki Saito Hiromichi Ryuto Nobuhisa Fukunishi Tomoko Abe Shigeo Takumi Shuhei Nasuda Koji Murai
- 出版者
- The Genetics Society of Japan
- 雑誌
- Genes & Genetic Systems (ISSN:13417568)
- 巻号頁・発行日
- vol.82, no.2, pp.167-170, 2007 (Released:2007-05-11)
- 参考文献数
- 13
- 被引用文献数
- 88 98
The einkorn wheat (Triticum monococcum) mutant, maintained vegetative phase (mvp), was induced by nitrogen ion-beam treatment and was identified by its inability to transit from the vegetative to reproductive phase. In our previous study, we showed that WAP1 (wheat APETALA1) is a key gene in the regulatory pathway that controls phase transition from vegetative to reproductive growth in common wheat. WAP1 is an ortholog of the VRN1 gene that is responsible for vernalization insensitivity in einkorn wheat. The mvp mutation resulted from deletion of the VRN1 coding and promoter regions, demonstrating that WAP1/VRN1 is an indispensable gene for phase transition in wheat. Expression analysis of flowering-related genes in mvp plants indicated that wheat GIGANTIA (GI), CONSTANS (CO) and SUPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (SOC1) genes either act upstream of or in a different pathway to WAP1/VRN1.
- 著者
- Yusaku MORITA Koji KANDABASHI Shigeyuki KAJIKI Hiroyuki SAITO Go MUTO Takahiro TABUCHI
- 出版者
- National Institute of Occupational Safety and Health
- 雑誌
- Industrial Health (ISSN:00198366)
- 巻号頁・発行日
- vol.60, no.4, pp.360-370, 2022-05-11 (Released:2022-08-01)
- 被引用文献数
- 2
This study evaluated the relationship between occupational injury risk and gig work, which included the exchange of labor for money between individuals or companies via digital platforms. As Japan has experienced a severe economic decline during the coronavirus disease 2019 (COVID-19) pandemic, an increasing number of individuals have engaged in gig work. While few studies have evaluated occupational risks in gig work, several traffic accidents associated with food delivery gig work have been reported in the mass media. In this study, 18,317 individuals completed an internet survey that collected information pertaining to their involvement in gig work and experience of related occupational injuries; data regarding several confounding factors were also recorded. Multiple logistic regression analysis showed that workers involved in gig work had a greater risk of any minor occupational injuries (odds ratio, 3.68; 95% confidence interval, 3.02–4.49) and activity-limiting injuries (odds ratio, 9.11; 95% confidence interval, 7.03–11.8) than those not involved in gig work, after adjusting for age, sex, household income, lifestyle factors, and work-related factors. The results of this study indicate that gig workers are exposed to greater occupational hazards during the COVID-19 pandemic. Additional studies are warranted to clarify the causal mechanism for this relationship.