- 著者
- Osamu FUKUTOMI Satomi SAKURAI Kunitoshi NADA Hideyuki MORITA Takahiro ARAI Keiko SUZUKI Yusuke AOKI Toshiyuki FUKAO Hiroko IWAKOSHI Yumiko CHIKAMATSU Tadao ORII
- 出版者
- Medical and Pharmaceutical Society for WAKAN-YAKU
- 雑誌
- Journal of Traditional Medicines (ISSN:18801447)
- 巻号頁・発行日
- vol.23, no.4, pp.151-152, 2006 (Released:2007-06-21)
- 参考文献数
- 6
小児の急性胃腸炎による嘔吐に対し,五苓散の注腸を行い有効性について検討した。症例は 6ヶ月から11歳までの336例で,平均年齢は3.7±2.3歳であった。方法は五苓散エキス顆粒2.5gを温生理食塩水20mlに溶解し注腸した。その後の症状の経過で有効性を評価した。症例全体の有効率は79%であった。この有効率は年齢による差は認めなかったが, 受診までの嘔吐回数とは有意な相関関係を認めた(p<0.01)。五苓散の注腸の有効率は他の報告でも高く評価されている。今回の結果でも有効率が高く副作用もないことから,小児の嘔吐を伴う急性胃腸炎の,点滴を行う前に行う治療としての有用性が示唆された。
- 著者
- Hideo Sasai Nobuyuki Shimozawa Takahiko Asano Norio Kawamoto Takahiro Yamamoto Takeshi Kimura Minako Kawamoto Eiko Matsui Toshiyuki Fukao
- 出版者
- 東北ジャーナル刊行会
- 雑誌
- The Tohoku Journal of Experimental Medicine (ISSN:00408727)
- 巻号頁・発行日
- vol.237, no.4, pp.323-327, 2015 (Released:2015-12-04)
- 参考文献数
- 11
- 被引用文献数
- 2 9
Cystathionine β-synthase (CBS) deficiency, well known as classical homocystinuria, is a rare autosomal recessive inborn error of homocysteine and sulfur metabolism. CBS converts homocysteine to cystathionine. The clinical features of untreated CBS deficiency include myopia, ectopia lentis, mental retardation, skeletal anomalies resembling Marfan syndrome, and thromboembolic events. Cerebral white matter lesions (CWMLs), identified in magnetic resonance imaging (MRI), are related to various clinical conditions including ischemia, inflammation, demyelination, infection, a tumor, and metabolic disorders such as phenylketonuria. The presence of CWMLs is, however, believed to be a very rare condition in CBS-deficient patients. Herein, we report reversible CWMLs associated with hypermethioninemia caused by poor protein restriction and betaine therapy in a 21-year-old male with pyridoxine-nonresponsive CBS deficiency. T2-weighted images (T2WI) and fluid-attenuated inversion-recovery (FLAIR) images showed diffuse high signal intensity in subcortical areas extending to the deep white matter. Diffusion-weighted images (DWI) showed high signal intensity, while apparent diffusion coefficient (ADC) map demonstrated decreased ADC value in the lesions. The course of improvement after correct methionine restriction was successively followed by brain MRI. The CWMLs had regressed at 1 month after restriction, and disappeared after 5 months. ADC values were very low before proper methionine restriction, but normalized after 2 months. Use of betaine in the presence of elevated plasma methionine may increase the risk of reversible CWMLs in some CBS-deficient patients.