著者

Stepanenko Valeriy F. Hoshi Masaharu Dubasov Yuriy V. SAKAGUCHI Aya YAMAMOTO Masayoshi ORLOV Mark Y. BAILIFF Ian K. IVANNIKOV Alexander I. SKVORTSOV Valeriy G. IASKOVA Elena K. KRYUKOVA Irina G. ZHUMADILOV Kassym S. ENDO Satoru TANAKA Kenichi APSALIKOV Kazbek N. GUSEV Boris I.

出版者

放射線影響学会 = Japan Radiation Research Society

雑誌

Journal of radiation research (ISSN:04493060)

巻号頁・発行日

vol.47, pp.A149-A158, 2006-02-28

参考文献数

27

被引用文献数

10 21

---

金沢大学環日本海域環境研究センター地球環境計測研究部門Spatial distributions of soil contamination by 137Cs (89 sampling points) and 239+240pu (76 points) near and within Dolon village were analyzed. An essential exponential decrease of contamination was found in Dolon village: the distance of a half reduction in contamination is about 0.87-1.25 km (in a northwest-southeast direction from the supposed centerline of the radioactive trace). This fact is in agreement with the available exposure rate measurements near Dolon (September 1949 archive data): on the basis of a few measurements the pattern of the trace was estimated to comprise a narrow 2 km corridor of maximum exposure rate. To compare computed external doses in air with local dose estimates by retrospective luminescence dosimetry (RLD) the gradient of radioactive soil contamination within the village was accounted for. The computed dose associated with the central axis of the trace was found to be equal to 2260 mGy (calculations based on archive exposure rate data). Local doses near the RLD sampling points (southeast of the village) were calculated to be in the range 466-780 mGy (averaged value: 645+/-70 mGy), which is comparable with RLD data (averaged value 460+/-92 mGy with range 380-618 mGy). A comparison of the computed mean dose in the settlement with dose estimates by ESR tooth enamel dosimetry makes it possible to estimate the "upper level" of the "shielding and behavior" factor in dose reduction for inhabitants of Dolon village which was found to be 0.28+/-0.068.

著者

KOBASHI ASAYA

出版者

Journal of Radiation Research Editorial Committee

雑誌

Journal of radiation research (ISSN:04493060)

巻号頁・発行日

vol.37, no.2, pp.81-95, 1996

参考文献数

27

被引用文献数

2 3

---

The radioactivities of the naturally occurring radionuclides (^<226>Ra, ^<228>Ra, ^<228>Th and ^<40>K) and a fallout nuclide (^<137>Cs) in books produced in Japan in the 20th century were measured by gamma-ray spectrometry to obtain information on radiation emitted from books. The respective concentration ranges of ^<226>Ra, ^<228>Ra, ^<228>Th ^<40>K, and ^<137>Cs were 0.2-6.4, 0.4-11. 2, 0.3-11.3, 1-112, and 0-3.6 Bq kg^<-1>. X-ray diffraction spectra of the papers used in book printing showed that pyrophyllite, talc, kaolinite, and calcium carbonate were contained as fillers. A comparison of the radioactivity contents of the pulp and filler indicated that most of ^<226>Ra, ^<228>Ra, and ^<228>Th in the books was present in the filler whereas ^<137>Cs was in the pulp. The pattern of the concentration of each nuclide vs. the year of issue of the book was investigated. Patterns for the naturally occurring radionuclides were similar and were explained by the kinds of filler used. The pattern for ^<137>Cs differed from the patterns of the naturally occurring radionuclides, having a marked peak in the mid-1960s.

著者

JAMES V. NEEL WILLIAM J. SCHULL AKIO A. AWA CHIYOKO SATOH HIROO KATO MASANORI OTAKE YASUHIKO YOSHIMOTO

出版者

Journal of Radiation Research Editorial Committee

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.32, no.SUPPLEMENT, pp.347-374, 1991 (Released:2006-05-31)

参考文献数

75

被引用文献数

5

---

The data collected in Hiroshima and Nagasaki during the past 40 years on the children of survivors of the atomic bombings and on the children of a suitable control population are analyzed on the basis of the newly revised estimates of radiation doses. No statistically significant effects emerge with respect to eight different indicators. Since, however, it may confidently be assumed some mutations were induced, we have taken the data at face value and calculated the minimal gametic doubling doses of acute radiation for the individual indicators at various probability levels. An effort has also been made to calculate the most probable doubling dose for the indicators combined. The latter value is between 1.7 and 2.2 Sv. It is suggested the appropriate figure for chronic radiation would be between 3.4 and 4.5 Sv. These estimates suggest humans are less sensitive to the genetic effects of radiation than has been assumed on the basis of past extrapolations from experiments with mice.

著者

SHOICHIRO FUJITA HIROO KATO WILLIAM J. SCHULL

出版者

Journal of Radiation Research 編集委員会

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.32, no.SUPPLEMENT, pp.154-161, 1991 (Released:2006-05-31)

参考文献数

24

被引用文献数

7 14

---

Numerous attempts have been made to estimate the distance at which 50% of the individuals exposed to the A-bombing of Hiroshima and Nagasaki died, ostensibly from their exposure to ionizing radiation. It is difficult to convert most of these distance estimates to a dose-related LD50, since radiation shielding was ignored. The recent reassessment of the atomic bomb radiation dosimetry has provided an opportunity for the estimation of the bone marrow LD50. There is a surprising concordance in the various estimates that have been made given the different groups of survivors involved and the methods used to estimate the LD50/60.

著者

酒井 一夫 岡田 重文

出版者

日本放射線影響学会

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.22, no.4, pp.415-424, 1981

被引用文献数

13 15

---

An alkaline separation technique originally established by Ahnstrom is modified to detect small amount of DNA damage in X-irradiated mouse leukemic L5178Y cells. It is made quantitative by calibration with an alkaline sucrose gradient centrifugation. The present method would make it possible to study DNA damage and its repair within a dose range of X-rays where cell survival and mutation are usually investigated. It is also useful for detecting DNA damage caused by chemicals.

著者

Franken Nicolaas A.P. Van Bree Chris Veltmaat Martijn A.T. RODERMOND HANS M. HAVEMAN JAAP BARENDSEN GERRIT W.

出版者

日本放射線影響学会

雑誌

Journal of radiation research (ISSN:04493060)

巻号頁・発行日

vol.42, no.2, pp.179-190, 2001-06

被引用文献数

3 25

---

Sensitization by bromodeoxyuridine (BrdUrd) and hyperthermia (HT) on cell reproductive death induced by ionizing radiation was analyzed using the linear-quadratic [S(D)/S(0)=exp{-( αD+ βD^2 )}] model. Plateau-phase human lung tumor cells (SW-1573) and human colorectal carcinonoma cells (RKO) were treated with BrdUrd, radiation and HT. LQ-analysis was performed at iso-incubation dose and at iso-incorporation level of BrdUrd, and at iso-HT doses and iso-survival levels after HT. Clonogenic assays were performed 24 h after treatment to allow repair of potentially lethal damage (PLD). In SW cells BrdUrd, HT or the combination significantly increased the α-parameter (factor 2.0- 5.7), without altering the β-parameter. In RKO cells sensitization with BrdUrd increased both α (factor 1.4) and β(factor 1.3) while HT only influenced β (factor 2.1-4.0). The combination did not further increase the α and β The results indicate that BrdUrd has its main effect on the parameter α, dominant at clinically relevant radiation doses but that HT can affect both α and β The addition of BrdUrd and HT provides a method to enhance the efficacy of radiotherapy.

著者

Sasaki Shunsaku Fukuda Nobuo

出版者

日本放射線影響学会

雑誌

Journal of radiation research (ISSN:04493060)

巻号頁・発行日

vol.49, no.6, pp.623-633, 2008-11-16

被引用文献数

3

---

Female B6C3F1 mice were irradiated at day 17 prenatal period, day 0, 7, 35, 105, 240, 365 and 550 postnatal period with doses of 0.10 to 5.70Gy gamma rays from ^<137>Cs. All mice were allowed to live through their entire life spans under a specific-pathogen free condition. The excess relative risk for prevalence at the time of death of ovarian tumors was used as a comprehensive measure of radiation effect. The excess relative risks at 1Gy were estimated for all irradiated groups based on the dose-response relationships and compared to each other. A marked increase in susceptibility was found during the age between day 17 prenatal and day 0 postnatal period. A drastic decrease in susceptibility was observed during the period between day 105 and day 240. The shape of the dose-response curve was downward concave in mice irradiated at day 0, 7, 35 or 105 postnatal period, whereas, the downward curvature of dose-response was not observed in mice irradiated at day 17 prenatal period, day 240, 365 or 550 postnatal period. It has become obvious that mice of the early postnatal, pre-puberty and young adult periods are highly susceptible to induction of ovarian tumors by gamma rays.

著者

Takeshi HIRANO

出版者

Journal of Radiation Research 編集委員会

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.49, no.4, pp.329-340, 2008 (Released:2008-07-17)

参考文献数

103

被引用文献数

54

---

Reactive oxygen species (ROS) are essentially harmful for living organisms, including human beings. It is well known that ROS-induced damage of cellular components may lead to human diseases, such as inflammatory diseases, degenerative diseases, or cancer. In particular, oxidative DNA damage is premutagenic, and thus, the generation of DNA damage and the failure of its removal are critical events for tumorigenesis or carcinogenesis. To prevent this disadvantage, living organisms have defense mechanisms against ROS-induced gene instability. Studies of 8-oxo-Gua and its main repair enzyme, 8-oxoguanine DNA glycosylase 1 (OGG1), are informative and useful, because 8-oxo-Gua is commonly observed in DNA, and OGG1 enzymes exist in a wide variety of living organisms. The importance of OGG1 was confirmed by polymorphism analyses and studies using knockout mice. Moreover, analyses of the influences of environmental factors on DNA damage and repair systems have confirmed the effects of heavy metals on 8-oxo-Gua formation and OGG1 expression. These studies revealed that the 8-oxo-Gua repair system is crucial for the prevention of mutation-related diseases, such as cancer. In this review, the advances in this field during the last two decades are described.

著者

Akiko UZAWA Koichi ANDO Yoshiya FURUSAWA Go KAGIYA Hiroshi FUJI Masaharu HATA Takeji SAKAE Toshiyuki TERUNUMA Michael SCHOLZ Sylvia RITTER Peter PESCHKE

出版者

Journal of Radiation Research 編集委員会

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.48, no.Suppl.A, pp.A75-A80, 2007 (Released:2007-05-19)

参考文献数

15

被引用文献数

20

---

Charged particle therapy depends on biological information for the dose prescription. Relative biological effectiveness or RBE for this requirement could basically be provided by experimental data. As RBE values of protons and carbon ions depend on several factors such as cell/tissue type, biological endpoint, dose and fractionation schedule, a single RBE value could not deal with all different radiosensitivities. However, any biological model with accurate reproducibility is useful for comparing biological effectiveness between different facilities. We used mouse gut crypt survivals as endpoint, and compared the cell killing efficiency of proton beams at three Japanese facilities. Three Linac X-ray machines with 4 and 6 MeV were used as reference beams, and there was only a small variation (coefficient of variance < 2%) in biological effectiveness among them. The RBE values of protons relative to Linac X-rays ranged from 1.0 to 1.11 at the middle of a 6-cm SOBP (spread-out Bragg peak) and from 0.96 to 1.01 at the entrance plateau. The coefficient of variance for protons ranged between 4.0 and 5.1%. The biological comparison of carbon ions showed fairly good agreement in that the difference in biological effectiveness between NIRS/HIMAC and GSI/SIS was 1% for three positions within the 6-cm SOBP. The coefficient of variance was < 1.7, < 0.6 and < 1.6% for proximal, middle and distal SOBP, respectively. We conclude that the inter-institutional variation of biological effectiveness is smaller for carbon ions than protons, and that beam-spreading methods of carbon ions do not critically influence gut crypt survival.

著者

佐々木 弘 吉永 春馬

出版者

日本放射線影響学会

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.12, no.3, pp.117-127, 1971-09

被引用文献数

1 3

---

The fate of HeLa cells irradiated with X-rays and fast neutrons was followed by cine and continual photographic procedures. The following interestings were made through detailed analysis of the films. (1) No differences could be observed between X- and neutron irradiated cells as to the types of cell abnormalities as well as modes of cell disintegration. (2) Cell fusion played an important role in reproductive cell death. Furthermore, cell fusion was observed between cells other than sisters, cousins, aunts or nieces. (3) In the pedigree of cells with colony-forming ability, these was a tendency for both cell death and normal cell division to occur in clusters of closely-related cells.

出版者

Journal of Radiation Research 編集委員会

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.42, no.4, pp.457-458, 2001 (Released:2002-02-28)

著者

Liren QIAN Fei CAO Jianguo CUI Yicun WANG Yuecheng HUANG Yunhai CHUAI Luqian ZAHO Hao JIANG Jianming CAI

出版者

Journal of Radiation Research 編集委員会

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.51, no.6, pp.741-747, 2010 (Released:2010-11-23)

参考文献数

35

被引用文献数

67

---

Most ionizing radiation-induced damage is caused by hydroxyl radicals, and the selective reduction of hydroxyl by hydrogen in vitro has been demonstrated previously. Irradiation of the heart can cause chronic cardiac disease. This study was designed to test the hypothesis that hydrogen-rich water (pure water saturated with molecular hydrogen), which is easy to use, induces cardioprotection against ionizing irradiation injury in mice. In this paper, we demonstrate that hydrogen can protect myocardium degeneration from radiation-induced injury, decrease myocardium malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG) levels, and increase myocardium endogenous antioxidants in vivo. We suggest that hydrogen has a cardioprotective effect against radiation induced injury.

著者

Takashi UNO Kouichi ISOBE Naoyuki UENO Ataru FUKUDA Satoshi SUDO Hiroaki SHIROTORI Isao KITAHARA Takanori FUKUSHIMA Hisao ITO

出版者

Journal of Radiation Research 編集委員会

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.51, no.4, pp.449-454, 2010 (Released:2010-07-29)

参考文献数

12

被引用文献数

12 3

---

The objective of this retrospective study was to report initial results of CyberKnife stereotactic radiotherapy (SRT) boost for tumors in the head and neck area. Between March 2008 and August 2009, 10 patients were treated with SRT boost using CyberKnife system due mainly to unfavorable condition such as tumors in close proximity to serial organs or former radiotherapy fields. Treatment sites were the external auditory canal in two, the nasopharynx in one, the oropharynx in three, the nasal cavity in one, the maxillary sinus in two, and the oligometastatic cervical lymph node in one. All patients underwent preceding conventional radiotherapy of 40 to 60 Gy. Dose and fractionation scheme of the Cyberknife SRT boost was individualized, and prescribed dose ranged from 9 Gy to 16 Gy in 3 to 4 fractions. Among four patients for whom dose to the optic pathway was concerned, the maximum dose was only about 3 Gy for three patients whereas 9.6 Gy in the remaining one patient. The maximum dose for the mandible in one of three patients with oropharyngeal cancer was 19.7 Gy, whereas majority of the bone can be spared by using non-isocentric conformal beams. For a patient with nasopharyngeal cancer, the highest dose in the brain stem was 15 Gy. However, majority of the brain stem received less than 40% of the maximum dose. Although a small volume high dose area within the normal structure could be observed in several patients, results of the present study showed potential benefits of the CyberKnife SRT boost.

著者

TAKADA JUN HOSHI MASAHARU NAGATOMO TSUNETO YAMAMOTO MASAYOSHI ENDO SATORU TAKATSUJI TOSHIHIRO YOSHIKAWA ISAO GUSEV BORIS I. SAKERBAEV ALEXANDER K. TCHAIJUNUSOVA NAILYA.J.

出版者

日本放射線影響学会

雑誌

Journal of radiation research (ISSN:04493060)

巻号頁・発行日

vol.40, no.4, pp.337-344, 1999-12

被引用文献数

13 33 44

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Accumulated external radiation doses of residents near the Semipalatinsk nuclear test site of the former USSR are presented as a results of study by the thermoluminescence technique for bricks sampled at several settlements in 1995 and 1996. The external doses that we evaluated from exposed bricks were up to about 100 cGy for resident. The external doses at several points in the center of Semipalatinsk City ranged from a background level to 60 cGy, which was remarkably high compared with the previously reported values based on military data. INTRODUCTION A total of 459 nuclear tests were conducted by the former Union of Soviet Socialist Republics (USSR) between 1949 and 1989 at the Semipalatinsk nuclear test site (SNTS) of Kazakhstan, including 87 atmospheric, 26 on the ground, and 346 underground explosions1). The total release of the energy equivalent of trinitrotoluene (TNT) of about 18 Mt was eleven hundred times that of the Hiroshima atomic bomb. However, previous reports concerning the effects of radiation on residents near the SNTS based on data provided by the Defense Department of the former USSR2, 3) did not involve direct experimental data concerning the effective equivalent dose. They just measured some doses for particular settlements after some nuclear explosions. These did not indicate an integrated dose of the residents of all the explosions. The technique of thermoluminescence dosimetry (TLD), which had been successfully applied in dosimetry for the Hiroshima and Nagasaki atomic bombs4, 5), enabled us to evaluate the accumulated external gamma ray doses of all the nuclear explosions at specific places in the Semipalatinsk test site. The TLD technique is well-established not only for instantaneous exposure as in A-bombs (Hiroshima and Nagasaki)6) but also in prolonged exposure to natural radiation, which is used in dating7). Moreover, this technique was applicable for dosimetry studies of radioactive fallout as shown in studies of the Chernobyl accident8,9).

著者

小平 潔

出版者

Journal of Radiation Research 編集委員会

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.5, no.2, pp.116-119, 1964-06-01 (Released:2006-08-29)

参考文献数

14

被引用文献数

3 5

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In Japan, Sr-90 in brown rice showed two peaks at October 1959 and October 1962, whereas Sr-90 in polished rice showed almost constant level, and quite less contamination. Cs-137 contamination was roughly 10 times of that of Sr-90 in polished rice. This ratio is higher than that of fall-out itself, which has been estimated as around 3. A discussion was made on the mechanisms, which can be important factors to give rise such a high Cs-137 contamination of polished rice: characteristic effect of NH+4 ion on the liberation of Cs+ ion from flooded rice soil, rate of absorption of Cs and Sr by plant roots as well as plant body surfaces, and rate of translocation of Cs and Sr in plants.

著者

Wei ZHANG Chunyan WANG Deqing CHEN Masako MINAMIHISAMATSU Hiroshige MORISHIMA Yongling YUAN Luxin WEI Tsutomu SUGAHARA Isamu HAYATA

出版者

Journal of Radiation Research 編集委員会

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.45, no.3, pp.441-446, 2004 (Released:2004-12-22)

参考文献数

26

被引用文献数

16

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Cytogenetic investigation of stable-type aberrations (translocations) was carried out with our improved methods on 28 elderly individuals in a high-background radiation area (HBRA) in China, and on 24 elderly individuals in a control area (CA). The level of radiation in HBRA is 3 to 5 times higher than in CA. The mean frequencies of translocations per 1,000 cells in HBRA and CA were 12.4 ± 5.3 and 10.0 ± 3.8, respectively. No significant difference was found in the frequencies between HBRA and CA (P>0.05, Mann-Whitney U test). When elderly individuals in HBRA and CA were classified into four subgroups of HBRA nonsmokers, HBRA smokers, CA nonsmokers, and CA smokers, a significant difference was found in the frequencies between CA smokers and CA nonsmokers (P<0.05, Mann-Whitney U test). Furthermore a tendency of difference (a near T-value of 0.05 level) was found in a comparison of HBRA smokers vs. CA nonsmokers. The present results indicate that the elevated level of natural radiation in HBRA plays a less significant part than smoking in bringing about the induction rate of stable-type aberrations (translocations) in those areas.

著者

HARUO EZAKI NOBUO TAKEICHI YASUHIKO YOSHIMOTO

出版者

Journal of Radiation Research 編集委員会

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.32, no.SUPPLEMENT, pp.193-200, 1991 (Released:2006-05-31)

参考文献数

7

被引用文献数

14 20

---

We analysed thyroid cancers which were diagnosed clinically or detected at autopsy during 22 years (1958 to 1979) in a sample of 75, 493 study subjects exposed in Hiroshima belonging to the extended LSS sample of the Radiation Effects Research Foundation. One hundred and twenty-five cases of clinical thyroid cancer (15 in males and 110 in females) were confirmed, giving a crude incidence rate per 100, 000 person-years of 2.7 for males, 12.4 for females and 8.6 for both sexes combined. There was a significant increase of thyroid cancer with increase of atomic bomb radiation dose (thyroid tissue dose based on T65D) in females and in the sexes combined. This tendency was predominant in those exposed at less than 19 years of age. Compared to the control group, the relative risk in the ≥0.50 Gy group was higher at 4.0 for males (not significant) and at 4.3 for females (p <0.01). Latent thyroid cancer was detected in 155 cases or 3.5% (2.5% for males and 4.5% for females) of the 4, 425 cases that came to autopsy during the same period. Compared to the control group, the relative risk in the 50 + rad group was 1.7 for males (not significant), 2.0 for females (p <0.05) and 1.9 for both sexes combined (p <0.05). New data obtained from autopsy cases between 1950 and 1985 have been added.

著者

JIANMING ZOU QUANFU SUN SUMINORI AKIBA YONGLING YUAN YONGRU ZHA ZUFAN TAO LUXIN WEI TSUTOMU SUGAHARA

出版者

Journal of Radiation Research 編集委員会

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.41, no.SUPPL, pp.S53-S62, 2000 (Released:2001-10-19)

参考文献数

17

被引用文献数

41

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The main purposes of this study were to identify the major determinants of nasopharyngeal carcinoma (NPC) in the high-background radiation areas (HBRA) in Yangjiang, China and to evaluate their potential confounding effects on the NPC risk associated with exposure to high background radiation. A matched case-control study was conducted using those who died of NPC during the period 1987-1995. Two controls were randomly selected for each case from those who died from causes other than malignancies and external causes. Cases and their controls were matched with respect to sex and the years of birth and death (±5 years). Study subjects' next-of-kin were interviewed using a standardized questionnaire to collect information on socioeconomic status, dietary habits, tobacco smoking and alcohol consumption, disease history, pesticide use, medical X-ray exposure, the family history of NPC and so on. We succeeded in interviewing 97 cases and 192 controls. Univariate conditional logistic regression analysis showed that NPC risk was associated with the consumption of salted fish, homemade pickles, and fermented soy beans, education levels, the history of chronic rhinitis, and the family history of NPC. Multivariate conditional logistic regression analysis revealed that education levels (Odds ratio (OR) for middle school or higher levels vs. no school education=3.8, 95% CI=1.2 to 11.8), salted fish intake (OR=3.2, 95% CI=1.7 to 6.1), the history of chronic rhinitis (OR=3.6, 95% CI=1.3 to 10.1), and the family history of NPC (OR=14.2, 95% CI=2.7 to 73.4) were independent risk factors of NPC. Tobacco smoking (OR=1.2, 95% CI=0.7 to 2.1), and alcohol consumption (OR=0.9, 95% CI=0.5 to 1.9) were not significantly related to NPC risk. The ORs of NPC risk comparing HBRA and a nearby control area before and after adjustment for the major risk determinants identified in the present study were 0.86 (95% CI=0.50 to 1.50) and 0.87 (95% CI=0.45 to 1.67), respectively. Salted fish intake was a strong risk factor of NPC. Education, the history of chronic rhinitis and the family history of NPC were also related to NPC risk. The exposure to high background radiation in HBRA of Yangjiang was not related to NPC risk with or without the adjustment for those major risk determinants of NPC.

著者

Nori NAKAMURA

出版者

Journal of Radiation Research 編集委員会

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.47, no.SupplementB, pp.B67-B73, 2006 (Released:2006-10-04)

参考文献数

26

被引用文献数

37

---

Genetic studies in the offspring of atomic bomb survivors have been conducted since 1948 at the Atomic Bomb Casualty Commission and its successor, the Radiation Effects Research Foundation, in Hiroshima and Nagasaki. Past studies include analysis of birth defects (untoward pregnancy outcome; namely, malformation, stillbirth, and perinatal death), chromosome aberrations, alterations of plasma and erythrocyte proteins as well as epidemiologic study on mortality (any cause) and cancer incidence (the latter study is still ongoing). There is, thus far, no indication of genetic effects in the offspring of survivors. Recently, the development of molecular biological techniques and human genome sequence databases made it possible to analyze DNA from parents and their offspring (trio-analysis). In addition, a clinical program is underway to establish the frequency of adult-onset multi-factorial diseases (diabetes mellitus, high blood pressure, and cardiovascular disease etc) in the offspring. The complementary kinds of data that will emerge from this three-pronged approach (clinical, epidemiologic, and molecular aspects) promise to shed light on health effects in the offspring of radiation-exposed people.

著者

OGUMA Nobuo SHIGETA Chiharu TANAKA Kimio KAMADA Nanao

出版者

日本放射線影響学会

雑誌

Journal of radiation research (ISSN:04493060)

巻号頁・発行日

vol.37, no.4, 1996-12