著者

中澤 秀夫

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:18802877)

巻号頁・発行日

vol.11, no.1, pp.29-36, 2015-02-15 (Released:2015-03-06)

被引用文献数

1

著者

大塚 茂

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.10, no.2, pp.121-122, 2014 (Released:2014-05-08)

著者

東 直行

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌

巻号頁・発行日

vol.13, no.1, pp.8-21, 2017

被引用文献数

1

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<p>Atopic dermatitis (AD) is the most common chronic and relapsing inflammatory skin disease. Both abnormal barrier function and abnormal immune function are closely involved in the etiology of AD. Patients with AD have been subdivided into abnormal filaggrin, normal filaggrin, high immunoglobulin E, normal IgE groups, and so on. Regarding local cytokine profiles in the skin of patients with AD, the involvement of Th2, Th22, and Th17 cells at the acute stage, and the involvement of Th2, Th22, and Th1 cells at the chronic stage have been suggested. The IL-9 level has been reported to be higher in patients with AD than in healthy individuals, but it has also been reported that there are no differences in IL-9 levels between patients with AD and normal individuals. Thus, the role of IL-9 is unclear. The serum IL-18 level is high and induces Th2 reactions in patients with AD. IL-21 is thought to suppress IgE formation, but its activity in relation to AD remains unknown. IL-22 is involved in hyperplasia, increased antimicrobial peptide formation, and reduced filaggrin in patients with AD. IL-25, IL-33, and thymic stromal lymphopoietin are produced in epidermal cells and activate type 2 innate lymphoid cells or premature dendritic cells, resulting in the induction of Th2 reactions. IL-31 is produced by Th2 cells, causing an itching sensation and scratching behavior. A correlation has been reported between serum IL-32 levels and the severity of dermatitis. IL-34 is an element of the control system that suppresses inflammation, but its activity in cases of AD is unknown. One published report describes a correlation between serum IL-37 levels and the severity of dermatitis, but this relationship has not been sufficiently clarified to date, and requires further analysis. In this review, the author has attempted to summarize reports on cytokine expression in patients with AD. The author expects that important cytokines and cells involved in the pathophysiology of AD will be revealed, contributing to strategies for treating AD.</p>

著者

野村 俊明

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.7, no.4, pp.166-168, 2011 (Released:2011-12-22)

参考文献数

14

著者

百束 比古 水野 博司 汲田 伸一郎

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.6, no.2, pp.56-57, 2010 (Released:2010-05-06)

参考文献数

3

著者

小平 祐造

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.11, no.1, pp.41-42, 2015-02-15 (Released:2015-03-06)

著者

岩切 勝彦 田中 由理子

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.6, no.1, pp.4-6, 2010 (Released:2010-03-05)

被引用文献数

1

著者

山崎 峰雄

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.8, no.4, pp.274-279, 2012 (Released:2012-12-28)

参考文献数

4

著者

石渡 明子 北村 伸 野村 俊明 根本 留美 石井 知香 若松 直樹 片山 泰朗 川並 汪一

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.9, no.1, pp.14-19, 2013 (Released:2013-03-11)

参考文献数

11

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Aim: Community Consultation Center was established in 2007 as a core facility of a project entitled "Community Support Network for Citizens with Mild Cognitive Impairment and Dementia" subsidized by the Ministry of Education, Culture, Sports, Science and Technology. This study reports the activity within the facility and users' outcome. Methods: At the facility, users consulted their memory problem, and a screening tool with a touch-panel type computer (TP) was used to check their memory loss. Dementia was suspected when the TP score was 12 or less points, and clinical psychotherapist implemented Mini-Mental state examination. All the results were summarized in reports, and we prompted users to see their primary doctors, or nearby medical institutes that we offered. In this study, we asked these medical institutes of their outcome. Informed consent was obtained from all users. Results: A total of 2,802 people visited the Center, and 1,565 people registered (male/female=519/1,046; mean age, 74 years). 561 people used the center twice or more. Among 1,354 who had TP, 722 users got a score under 12 (46.1%). A total of 409 responses from medical institutes were collected. The data revealed that Mild cognitive impairment (MCI) was 11.2%, Alzheimer's disease was 37.1%, and vascular dementia was 8.00%. Conclusion: These results indicate that approximately half of the users of the Center was suspected dementia, and a prevalence of both MCI and dementia reached to about 60%. This Center has proven to be useful for early detection and diagnosis.

著者

井上 哲夫

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.9, no.2, pp.69-76, 2013 (Released:2013-05-08)

著者

馬場 俊吉

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.9, no.2, pp.54-60, 2013 (Released:2013-05-08)

著者

澤 芳樹

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.5, no.1, pp.22-26, 2009 (Released:2009-04-15)

参考文献数

7

著者

小澤 一史 松崎 利行

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.5, no.4, pp.215-220, 2009 (Released:2009-11-17)

参考文献数

9

被引用文献数

1 1

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Immunohistochemistry is concerned with the detection of specific biological substances at the light and electron microscopic levels with antibodies labeled with visible markers, such as horseradish peroxidase and colloidal gold. In particular, the immunohistochemistry of electron microscopy has provided much morphological and biological information. Immunoelectron microscopy can be classified into three methods, i.e., pre-embedding, postembedding, and nonembedding methods, on the basis of the step during which the immunoreaction is applied to the biological specimens. Each method has both advantages and disadvantages, so we should select the method according to the biological purpose. An overview of immunoelectron microscopy is given, and several electron micrographs using immunohistochemical techniques are shown.

著者

吉田 寛 真々田 裕宏 谷合 信彦 山下 精彦 田尻 孝

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.1, no.4, pp.161-167, 2005 (Released:2005-11-09)

参考文献数

67

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Bleeding from esophagogastric varices is a catastrophic complication of chronic liver disease. We have been attempted surgery, embolization, and endoscopic treatment for the treatment of esophagogastric varices. Endoscopic injection sclerotherapy (EIS) is an established treatment for esophageal varices. EIS is associated with a high incidence of local and systemic complications. Endoscopic variceal ligation (EVL) is increasingly used because of its safety and simplicity and because no sclerosant is used. Nevertheless, EVL is not always effective, and early recurrences have been reported. Furthermore, most patients with esophageal varices treated endoscopically require treatment for recurrent varices. We invented that EVL performed three times at bimonthly intervals. EVL performed at bimonthly intervals for the treatment of esophageal varices attained a higher complete eradication rate, a lower recurrence rate, and a lower additional treatment rate. It is generally believed that bleeding from gastric varices is more severe than bleeding from esophageal varices, but bleeding from gastric varices occurs less commonly than from esophageal varices. The endoscopic risk factors for bleeding from esophageal varices include presence of raised red markings, cherry-red spots, blue color, and large size. However the risk factors for bleeding from gastric varices have yet to be characterized. Once gastric variceal hemorrhage did occur, bleeding from these varices was successfully stopped in all cases. Therefore, prophylactic treatment of gastric varices is not recommended.

著者

水村 直 汲田 伸一郎

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.3, no.3, pp.125-127, 2007 (Released:2007-07-12)

被引用文献数

1