著者

上田 浩史 山崎 正利

出版者

日本炎症・再生医学会

雑誌

炎症 (ISSN:03894290)

巻号頁・発行日

vol.13, no.4, pp.337-340, 1993-07-31 (Released:2010-04-12)

参考文献数

15

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Tumor necrosis factor-α (TNF-α), a cytokine secreted by macrophages, was recently recognized as an important molecule in host defense mechanism. However, its overproduction is also implied in many acute and chronic disease states. The inhibition of TNF-α overproduction, therefore, leads to suppression of acute and chronic inflammation. This work was undertaken to ascertain whether vegetable juice from perilla leaf, which may be a new candidate for an antiinflammatory reagent, can inhibit the endogenous production of TNF-α in mice.Both red and green perilla juice significantly inhibited TNF-α production byperos administration. Perilla juice showed nearly the same level of an inhibitory activity against TNF-α production as did Saibokuto, an antiinflammatory reagent. The inhibitory activity was stable for heat treatment (100°C, 10 min) . Perilla contains an active molecule (s) which can inhibit a host from releasing TNF-α. This molecule thus may suppress host defense systems as well as antiinflammatory drugs such as glucocorticoid or Saibokuto.

著者

松本 慶蔵

出版者

日本炎症・再生医学会

雑誌

炎症 (ISSN:03894290)

巻号頁・発行日

vol.2, no.4, pp.576, 1982-11-01 (Released:2010-04-12)

被引用文献数

1 1

著者

藤田 浩

出版者

日本炎症・再生医学会

雑誌

炎症 (ISSN:03894290)

巻号頁・発行日

vol.16, no.3, pp.147-153, 1996-05-20 (Released:2010-04-12)

参考文献数

20

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Vascular endothelial cells (ECs) have various functions such as the maintenance of vascular permeability, control of vascular tonus and resistance to thrombosis.During inflammation, ECs also play a role in angiogenesis and transmigration of the leukocytes. EC injury induces inflammatory changes, vasculitis and so on. We examined the mechanism of vascular EC injury induced by the leukocytes from the standpoint of active oxygen species and adhesion molecules, CD11/CD18 and ICAM-1, EC jnjury induced by the leukocytes was due to the hydroxyl radical production from xanthine oxidase using hydrogen peroxide from the leukocytes.In addition, CD11/CD18 and ICAM-1 induced vascular EC injury and the conversion of xanthine dehydrogenase to xanthine oxidase. The conversion might be elicited by tyrosine kinase activation.

著者

善如寺 路子 佐藤 則之 宮崎 誠 梅枝 愛郎 森 昌朋

出版者

日本炎症・再生医学会

雑誌

炎症 (ISSN:03894290)

巻号頁・発行日

vol.16, no.6, pp.419-423, 1996-11-30 (Released:2010-04-12)

参考文献数

8

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The chronic fatigue syndrome (CFS) is a condition of unknown etiology, characterized by an extreme fatigue that is exacerbated by minimal physical activity. Immunological abonormality is prevalent in patients with CFS (e. g. abnormal functions of natural killer cell, macrophage, and lymphocyte) . However, in our knowledge, no study has been reported about neutrophil function, so that we have investigated a neutrophil bactericidal function, luminol-dependent chemiluminescence (L-DCL), in a 24-years old female with CFS. L-DCL under whole blood condition was apparently increased, while L-DCL from separated neutrophils was in normal range. A combination therapy with vitamin C, vitamin E, and eicosapentanoic acid, those are known to be antioxidant drugs and to inhibit a generation of oxygen derived free radicals from neutrophils, apparently improved her symptoms and L-DCL under whole blood condition. These data suggest that symptoms of CFS may be partially caused by inflammatory mediators such as oxygen derived free radicals and the combination therapy may be useful to improve the symptoms of CFS. It may be possible that the measurement of neutrophil bactericidal function is available to evaluate the condition of CFS.

著者

熊谷 朗

出版者

日本炎症・再生医学会

雑誌

炎症 (ISSN:03894290)

巻号頁・発行日

vol.7, no.5, pp.403-404, 1987

著者

馬場 駿吉 高坂 知節 馬場 廣太郎 斎藤 洋三 坂倉 康夫 岩田 重信 西村 忠郎 石川 哮 小川 暢也

出版者

日本炎症・再生医学会

雑誌

炎症 (ISSN:03894290)

巻号頁・発行日

vol.12, no.4, pp.379-397, 1992-07-10 (Released:2010-04-12)

参考文献数

11

被引用文献数

4 2

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The therapeutic effects of IPD-1151 T, a new anti-allergic agent, were compared with those of Tranilast in 356 patients with allergic rhinitis. The daily dosage was 300 mg (one capsule each, t.i.d.) for IPD-1151 T and 300 mg (one capsule each, t.i.d.) for Tranilast. Both test drugs were orally given for 6 weeks.The results of this study are summarized as follows :(1) IPD-1151 T showed significant superiority to Tranilast in “final global improvement rating”. Improvement rating was 55.0% for IPD-1151 T and 37.8% for Tranilast in terms of “moderate” plus “marked” improvement category.(2) The item evaluated, “overall safety rating” showed significant superiority of IPD-1151 T to Tranilast. The incidence of an adverse reaction or abnormal laboratory finding was noted as 3.7% fo IPD-1151 T and 11.0% of Tranilast.(3) The item evaluated, “global utility rating” showed significant superiority of IPD-1151 T to Tranilast. The utility rating was calculated as 53.2% of IPD-1151 T and 34.7% of Tranilast in terms of “moderately” plus “markedly” useful category.(4) Side effects were observed in 6 patients (3.7%) of IPD-1151 T and 18 patients (11.0%) Tranilast. All of these symptoms disappeared by symptomatic treatment or discontinued test drug.All the above results indicate that IPD-1151 T is safer and more effective than Tranilast. Therefore, IPD-1151 T is judged as a highly useful anti-allergic agent for the treatment of allergic rhinitis.

著者

小林 豊一 原田 ひとみ 柴田 健介 廣瀬 俊一

出版者

The Japanese Society of Inflammation and Regeneration

雑誌

炎症 (ISSN:03894290)

巻号頁・発行日

vol.13, no.4, pp.383-386, 1993

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The effect of several agents on mitogen-induced proliferative response<I>in vitro</I>was studied by using colorimetric MTT [3- (4, 5-dimenthyl-2-thiazolyl) -2, 5-diphenyl-2H tetrazolium bromide] assay. Immuno-modulator levamisole and TOK-8801 enhanced concanavalin A and lipopolysaccharide response in murine splenocytes at concentrations of 10<SUP>-6</SUP>-10<SUP>-5</SUP>M and 10<SUP>-4</SUP>M, respectively. Immunosuppressant mizoribine decreased dose dependently this response.<BR>These results show that MTT assay may be a useful method for the evaluation of immunological affecting agents on cell proliferative response.

著者

近藤 元治

出版者

日本炎症・再生医学会

雑誌

炎症 (ISSN:03894290)

巻号頁・発行日

vol.20, no.4, pp.354-355, 2000-07-10 (Released:2010-04-12)

著者

丹羽 靱負 小室 俊夫

出版者

日本炎症・再生医学会

雑誌

炎症 (ISSN:03894290)

巻号頁・発行日

vol.11, no.2, pp.135-141, 1991-03-10 (Released:2010-04-12)

参考文献数

32

被引用文献数

2

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Far infrared ray (4-14 μm) emitting materials or products including platinum electro-magnetic wave fiber have recently been widely used for improving various disorders, promoting health and beauty, and preserving food freshness etc. This mechanisms is to decrease the size of water structure (cluster) by cleaving the bonds of H2O in polymer, which leads to the better penetration of water into the cell mem-brane with resultant increase in intracellular calcium concentration [Ca2+] i and potentiation of cell activa-tion. In this connection, we examined the effect of this platinum colloid fiber on [Ca2+] i, chemotaxis, phagocytosis and O-2 generation of normal human neutrophils, and blastogenesis of lymphocytes. Its effect on lipid peroxidation from unsaturated fatty acids was also tested. The test tubes containing neutro-phils and lymphocytes, and docosahexaenoic acid were surrounded and contacted with platinum colloid fiber.The result revealed that platinum fiber significantly enhanced [Ca2+] i, chemotaxis, phagocytosis and O-2 generation by normal neutrophils, and the blastogenesis of the lymphocytes. Lipid peroxidation was also markedly inhibited. Our study suggests that platinum colloid fiber promotes our health by potentiating the cell function.