著者
深澤 俊行 菊地 誠志 濱田 毅 田代 邦雄
出版者
日本炎症・再生医学会
雑誌
炎症 (ISSN:03894290)
巻号頁・発行日
vol.20, no.3, pp.209-213, 2000-05-29 (Released:2010-04-12)
参考文献数
18

The clinical features of MS in Japanese are said to be characterized by high incidence of optico-spinal MS (OS-MS), although the frequency of it has recently decreased. The term OS-MS is used to describe a subgroup of patients diagnosed with MS, in which the clinically determined lesions are confined to the optic nerves and the spinal cord. The OS-MS is characterized by a female preponderance, a later onset, a higher score of the expanded disability status scale of Kurtzke (EDSS), milder abnormalities on brain MRIs, higher sero-positive rates for some autoantibodies, and higher cell counts and protein levels in the cerebrospinal fluid, compared with conventional MS. The OS-MS is positively associated with HLA-DPB1*0501 allele, and the HLA prohile are different between OS-MS and conventional MS. Therefore, the OS-MS is immunogenetically as well as clinically a distinct subtype of MS.
著者
藤井 恵美子 村木 篁
出版者
日本炎症・再生医学会
雑誌
炎症 (ISSN:03894290)
巻号頁・発行日
vol.15, no.2, pp.155-160, 1995-03-31 (Released:2010-04-12)
参考文献数
17
被引用文献数
1 1

We examined the changes in vascular permeability induced by inflammatory mediators in mouse skin by the Pontamine sky blue (PSB) leakage technique. Five min after i.v. administration of PSB, mediators or saline were injected (0.1 ml/site, s.c.) into the back. Sixty min later, the dye accumulated in the skin was determined colorimetrically. Plateletactivating factor (PAF, 45-180 pmol/site), 5-hydroxy-tryptamine (5-HT, 120-960 pmol/site), substance P (100-1, 000 pmol/site) and histamine (550-5, 500 pmol/site) produced dose-related increases in vascular permeability. The dose response curve induced by bradykinin (20-80 nmol/site) was bellshaped. Pretreatment with indomethacin significantly reduced the increase in vascular permeability elicited by the 5 substances tested. Coadministration of prostaglandin (PG) E2 partially reversed the inhibitory effect of indomethacin on the PAF- or histamine induced-increase in vascular permeability. Increases in vascular permeability induced by 5-HT, substance P and bradykinin were inhibited by NG-nitro-l-arginine methyl ester (L-NAME) and methylene blue, but not by D-NAME ; however, PAF-and histamine-induced increases in vascular permeability were not affected by L-NAME.These results suggest that eicosanoids may play a role in the effect of all 5 substances tested, and especially the increases in plasma extravasation induced by PAF and histamine are mediated by the production of PGE2, and that NO may play a role, at least partly, in the case of 5-HT, substance P and bradykinin.
著者
吉良 潤一
出版者
日本炎症・再生医学会
雑誌
炎症 (ISSN:03894290)
巻号頁・発行日
vol.20, no.2, pp.137-144, 2000-03-29 (Released:2010-04-12)
参考文献数
8
被引用文献数
2 1

We recently reported the occurrence of myelitis in adults with atopic dermatitis (AD) . In order to clarify the clinical features of myelitis with atopy, we retrospectively studied 68 consecutive patients with acute or subacute myelitis diagnosed in Kyushu University Hospital during the past 20 years. Of 40 patients with myelitis seen between 1994 and 1998, 19 (48%) had either AD or bronchial asthma (BA), while 2 of 28 (7%) myelitic patients treated between 1979 and 1993 did. Of the 40 patients with myelitis diagnosed between 1994 and 1998, 29 (73%) had hyperlgEaemia and 32 (80%) had mite antigen-specific IgE, while of 82 healthy controls and 43 patients with neurodegenerative disorders, 21% and 23% had hyperlgEaemia and 40% and 32% had mite antigen-specific IgE respectively. Seventeen myelitic patients with AD showed an involvement of primarily the posterior column of the spinal cord and paresthesia/dysesthesia in all four limbs, whereas 3 patients with BA, including 2 adults, showed most common involvement of the anterior horn cells with muscle weakness and atrophy following acute asthmatic attacks. In addition, 12 myelitic patients who had hyperlgEaemia and IgE antibodies to mite antigens but neither AD nor BA also showed partial involvement of the spinal cord. Among these myelitis patients with atopy, pleocytosis in the cerebrospinal fluid was rare, peripheral blood eosinophilia was frequent and corticosteroids were less beneficial. These findings suggest an emergence of myelitis associated with atopy in Japan.
著者
藤田 浩
出版者
日本炎症・再生医学会
雑誌
炎症 (ISSN:03894290)
巻号頁・発行日
vol.16, no.3, pp.147-153, 1996-05-20 (Released:2010-04-12)
参考文献数
20

Vascular endothelial cells (ECs) have various functions such as the maintenance of vascular permeability, control of vascular tonus and resistance to thrombosis.During inflammation, ECs also play a role in angiogenesis and transmigration of the leukocytes. EC injury induces inflammatory changes, vasculitis and so on. We examined the mechanism of vascular EC injury induced by the leukocytes from the standpoint of active oxygen species and adhesion molecules, CD11/CD18 and ICAM-1, EC jnjury induced by the leukocytes was due to the hydroxyl radical production from xanthine oxidase using hydrogen peroxide from the leukocytes.In addition, CD11/CD18 and ICAM-1 induced vascular EC injury and the conversion of xanthine dehydrogenase to xanthine oxidase. The conversion might be elicited by tyrosine kinase activation.
著者
善如寺 路子 佐藤 則之 宮崎 誠 梅枝 愛郎 森 昌朋
出版者
日本炎症・再生医学会
雑誌
炎症 (ISSN:03894290)
巻号頁・発行日
vol.16, no.6, pp.419-423, 1996-11-30 (Released:2010-04-12)
参考文献数
8

The chronic fatigue syndrome (CFS) is a condition of unknown etiology, characterized by an extreme fatigue that is exacerbated by minimal physical activity. Immunological abonormality is prevalent in patients with CFS (e. g. abnormal functions of natural killer cell, macrophage, and lymphocyte) . However, in our knowledge, no study has been reported about neutrophil function, so that we have investigated a neutrophil bactericidal function, luminol-dependent chemiluminescence (L-DCL), in a 24-years old female with CFS. L-DCL under whole blood condition was apparently increased, while L-DCL from separated neutrophils was in normal range. A combination therapy with vitamin C, vitamin E, and eicosapentanoic acid, those are known to be antioxidant drugs and to inhibit a generation of oxygen derived free radicals from neutrophils, apparently improved her symptoms and L-DCL under whole blood condition. These data suggest that symptoms of CFS may be partially caused by inflammatory mediators such as oxygen derived free radicals and the combination therapy may be useful to improve the symptoms of CFS. It may be possible that the measurement of neutrophil bactericidal function is available to evaluate the condition of CFS.
著者
熊谷 朗
出版者
日本炎症・再生医学会
雑誌
炎症 (ISSN:03894290)
巻号頁・発行日
vol.7, no.5, pp.403-404, 1987
著者
馬場 駿吉 高坂 知節 馬場 廣太郎 斎藤 洋三 坂倉 康夫 岩田 重信 西村 忠郎 石川 哮 小川 暢也
出版者
日本炎症・再生医学会
雑誌
炎症 (ISSN:03894290)
巻号頁・発行日
vol.12, no.4, pp.379-397, 1992-07-10 (Released:2010-04-12)
参考文献数
11
被引用文献数
4 2

The therapeutic effects of IPD-1151 T, a new anti-allergic agent, were compared with those of Tranilast in 356 patients with allergic rhinitis. The daily dosage was 300 mg (one capsule each, t.i.d.) for IPD-1151 T and 300 mg (one capsule each, t.i.d.) for Tranilast. Both test drugs were orally given for 6 weeks.The results of this study are summarized as follows :(1) IPD-1151 T showed significant superiority to Tranilast in “final global improvement rating”. Improvement rating was 55.0% for IPD-1151 T and 37.8% for Tranilast in terms of “moderate” plus “marked” improvement category.(2) The item evaluated, “overall safety rating” showed significant superiority of IPD-1151 T to Tranilast. The incidence of an adverse reaction or abnormal laboratory finding was noted as 3.7% fo IPD-1151 T and 11.0% of Tranilast.(3) The item evaluated, “global utility rating” showed significant superiority of IPD-1151 T to Tranilast. The utility rating was calculated as 53.2% of IPD-1151 T and 34.7% of Tranilast in terms of “moderately” plus “markedly” useful category.(4) Side effects were observed in 6 patients (3.7%) of IPD-1151 T and 18 patients (11.0%) Tranilast. All of these symptoms disappeared by symptomatic treatment or discontinued test drug.All the above results indicate that IPD-1151 T is safer and more effective than Tranilast. Therefore, IPD-1151 T is judged as a highly useful anti-allergic agent for the treatment of allergic rhinitis.
著者
小林 豊一 原田 ひとみ 柴田 健介 廣瀬 俊一
出版者
The Japanese Society of Inflammation and Regeneration
雑誌
炎症 (ISSN:03894290)
巻号頁・発行日
vol.13, no.4, pp.383-386, 1993

The effect of several agents on mitogen-induced proliferative response<I>in vitro</I>was studied by using colorimetric MTT [3- (4, 5-dimenthyl-2-thiazolyl) -2, 5-diphenyl-2H tetrazolium bromide] assay. Immuno-modulator levamisole and TOK-8801 enhanced concanavalin A and lipopolysaccharide response in murine splenocytes at concentrations of 10<SUP>-6</SUP>-10<SUP>-5</SUP>M and 10<SUP>-4</SUP>M, respectively. Immunosuppressant mizoribine decreased dose dependently this response.<BR>These results show that MTT assay may be a useful method for the evaluation of immunological affecting agents on cell proliferative response.
著者
丹羽 靱負 小室 俊夫
出版者
日本炎症・再生医学会
雑誌
炎症 (ISSN:03894290)
巻号頁・発行日
vol.11, no.2, pp.135-141, 1991-03-10 (Released:2010-04-12)
参考文献数
32
被引用文献数
2

Far infrared ray (4-14 μm) emitting materials or products including platinum electro-magnetic wave fiber have recently been widely used for improving various disorders, promoting health and beauty, and preserving food freshness etc. This mechanisms is to decrease the size of water structure (cluster) by cleaving the bonds of H2O in polymer, which leads to the better penetration of water into the cell mem-brane with resultant increase in intracellular calcium concentration [Ca2+] i and potentiation of cell activa-tion. In this connection, we examined the effect of this platinum colloid fiber on [Ca2+] i, chemotaxis, phagocytosis and O-2 generation of normal human neutrophils, and blastogenesis of lymphocytes. Its effect on lipid peroxidation from unsaturated fatty acids was also tested. The test tubes containing neutro-phils and lymphocytes, and docosahexaenoic acid were surrounded and contacted with platinum colloid fiber.The result revealed that platinum fiber significantly enhanced [Ca2+] i, chemotaxis, phagocytosis and O-2 generation by normal neutrophils, and the blastogenesis of the lymphocytes. Lipid peroxidation was also markedly inhibited. Our study suggests that platinum colloid fiber promotes our health by potentiating the cell function.