著者

Yukihiko Ito Aya Mizukuchi Mitsuo Kise Hiromichi Aoto Shigeru Yamamoto Rie Yoshihara Jyunichi Yokoyama

出版者

徳島大学医学部

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.52, no.3,4, pp.159-164, 2005 (Released:2005-09-20)

参考文献数

28

被引用文献数

31 75

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Effects of pre-germinated brown rice (PGBR) on postprandial blood glucose and insulin concentrations were compared with brown rice (BR) and white rice (WR) in two studies. In the first study, we investigated the time course of postprandial blood glucose and insulin concentrations after ingesting 25% (W/V) glucose solution, PGBR, BR or WR in 19 healthy young subjects. In the second study, dose-dependent effect of PGBR on the time course of postprandial blood glucose concentrations was compared among 4 different mixtures of PGBR and WR in 13 healthy young subjects. They were solely PGBR, 2/3 PGBR (PGBR: WR=2: 1), 1/3 PGBR (PGBR: WR=1: 2) and solely WR. Each sample was studied on a different day. The samples were selected randomly by the subjects. All the rice samples contained 50g of available carbohydrates. The previous day the subjects ate the assigned dinner by 9:00 pm and then were allowed only water until the examination. The next morning, they ingested each test rice sample with 150ml of water in 5-10 min. Blood was collected into capillary tubes from finger at 0, 30, 60, 90 and 120 min after the ingestion. The incremental areas under the curve (IAUC) of blood glucose concentrations (IAUC-Glc) for 120 min after the administration of PGBR and BR were lower than those after WR. In contrast the IAUC-Glc of BR and PGBR were not different (Study 1). The higher the ratio of PGBR/WR, the lower the glycemic index became (Study 2). These results suggest that intake of PGBR instead of WR is effective for the control of postprandial blood glucose concentration without increasing the insulin secretion. J. Med. Invest. 52: 159-164, August, 2005

著者

Tamami Iwamoto Kazuaki Hosoda Reiko Hirano Hideaki Kurata Akiyo Matsumoto Wataru Miki Masumi Kamiyama Hiroshige Itakura Shigeru Yamamoto Kazuo Kondo

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

vol.7, no.4, pp.216-222, 2000 (Released:2011-09-20)

参考文献数

42

被引用文献数

185 224

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Marine animals produce astaxanthin which is a carotenoid and antioxidant. In this study we determined the in vitro and ex vivo effects of astaxanthin on LDL oxidation. The oxidation of LDL was measured in a 1 ml reaction system consisting of increasing concentrations of astaxanthin (12.5, 25.0, 50.0 μg/ml), 400 μM V-70 (2, 2'-azobis (4-methoxy-2, 4-dimethylvaleronitrile)), and LDL (70 μg/ml protein). Astaxanthin dose, dependently significantly prolonged the oxidation lag time (31.5, 45.4, 65.0 min) compared with the control (19.9 min). For the ex vivo study 24 volunteers (mean age 28.2 [SD 7.8] years) consumed astaxanthin at doses of 1.8, 3.6, 14.4 and 21.6 mg per day for 14 days. No other changes were made in the diet. Fasting venous blood samples were taken at days 0, +14. LDL lag time was longer (5.0, 26.2, 42.3 and 30.7% respectively) compared with day O after consuming astaxanthin at doses of 1.8, 3.6, 14.4 and 21.6 mg for 14 days compared with day O, but there was no difference in oxidation of LDL between day O (lag time 59.9 + 7.2 min) and day 14 (57.2 ± 6.0 min) in the control group. Our results provide evidence that consumption of marine animals producing astaxanthin inhibits LDL oxidation and possibly therefore contributes to the prevention of atherosclerosis.

著者

Koji KOBAYASHI Satoshi NAKAGAWA Jozef MLAÁDEK Masahiro KAGAMI Peter MEUSBURGER Hiroshi SASAKI Koji KOBAYASHI Masaaki KUREHA Teresa CZYZ Ivan BICIK Martin HAMPL Antal AUBERT Jörg MATER Mitsuru YAMAMOTO Lidia SASAKI Shigeru YAMAMOTO

出版者

The Association of Japanese Geographers

雑誌

地理学評論 (ISSN:13479555)

巻号頁・発行日

vol.76, no.5, pp.392-403, 2003-04-01 (Released:2008-12-25)

著者

Saiko Shikanai Ly Koung Ry Hitomi Takeichi Suzuki Emiko Pann San Nobuko Sarukura Sumiko Kamoshita Shigeru Yamamoto

出版者

徳島大学医学部

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.61, no.1.2, pp.72-78, 2014 (Released:2014-04-04)

参考文献数

21

被引用文献数

4 11

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Because of the tastiness of sugars, it is easy to consume more than an adequate amount. There are many research reports that excess sugar intake contributes to dental decay, obesity, diabetes etc. Continuing economic development in Cambodia has made it easier than before for people to consume sugars in their daily life. Currently, isomerized sugar (a mixture of glucose and fructose) made from starches is commonly used in commercial beverages because of its low price. However, in Cambodia and Japan, sugar composition tables that include not only sucrose but also glucose, fructose, lactose and maltose have not been available. Prior to the present nutrition surveys, we made sugar composition tables for both countries. In this study we tried to estimate the intakes of various sugars by children in Cambodia and Japan and to determine the relationship between intake and body weight. Nutrition surveys of children aged 7, 10 and 13 years old were conducted for 3 nonconsecutive days by the 24 h recall method in 89 Cambodian children living in the capital city of Cambodia, Phnom Penh, and 151 Japanese children living in 3 prefectures from north to south. Height and weight of children in Cambodia and Japan were similar until 10 years old but at 13 years old, the Cambodians were shorter and lighter than the Japanese. We could not observe any differences in BMI in either country. The sugar intakes from beverages and snacks were not different among the different gender and age. Thus we combined the mean total sugar intake for Cambodian and Japanese, 28.42 ± 25.28 g and 25.69 ± 16.16 g respectively. These were within the range of WHO recommendations (less than 10% of energy intakes). Cambodian children consumed about 46% of sugars from commercial beverages and snacks and Japanese children 26%. This means that for Cambodians half of the sugars came from isomerized sugar made from starches. Relationships between sugar intake and body weight were not observed in both countries. In conclusion, the Cambodian children consumed about 46% of sugar from glucose and fructose (probably in the form of isomerized sugar), while the Japanese children took 26%; however, the intakes in both countries met the WHO recommendation and there was no relationship to body weight. J. Med. Invest. 61: 72-78, February, 2014

著者

Thi Nhung BUI Thi Hop LE Do Huy NGUYEN Quang Binh TRAN Thi Lam NGUYEN Danh Tuyen LE Do Van Anh NGUYEN Anh Linh VU Hiromichi AOTO Yasuhide OKUHARA Yukihiko ITO Shigeru YAMAMOTO Mitsuo KISE

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.60, no.3, pp.183-187, 2014 (Released:2014-07-30)

参考文献数

35

被引用文献数

3 36 7

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We have reported that newly diagnosed type 2 diabetes mellitus (DM) patients in Vietnam have a low body mass index (BMI) of around 23 and that the major factor for this is high white rice (WR) intake. Brown rice (BR) is known to be beneficial in the control of blood glucose levels; however, it has the property of unpleasant palatability. Pre-germinated brown rice (PGBR) is slightly germinated by soaking BR in water as this reduces the hardness of BR and makes it easier to eat. This study was designed to evaluate the effect of a 4-mo PGBR administration on various parameters in Vietnamese women aged 45-65 y with impaired glucose tolerance (IGT). Sixty subjects were divided into a WR or PGBR group. For the first 2 wk, WR was replaced by 50% PGBR, then for 2 wk by 75% PGBR and from the second month 100%. Before the beginning of the study and at the end of the study, 1) anthropometric measurements, 2) a nutrition survey for 3 nonconsecutive days by the 24 h recall method and 3) blood biochemical examinations were conducted. Fasting plasma concentrations of glucose and lipids and the obesity-related measurements and blood pressure were favorably improved only in the PGBR diet group. The present results suggest that replacing WR with PGBR for 4 mo may be useful in controlling body weight as well as blood glucose and lipid levels in Vietnamese women with IGT.

著者

Masafumi AKISAKA Liu ASATO Yin-Ching CHAN Makoto SUZUKI Tatsu UEZATO Shigeru YAMAMOTO

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.42, no.3, pp.241-248, 1996 (Released:2009-04-28)

参考文献数

14

被引用文献数

12 20

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Energy and nutrient requirements of younger people have been well studied, unlike that of centenarians. The average life span of the Japanese is the longest in the world, and the population of the very aged is rapidly growing. In addition, the average life span of Okinawan people is the longest in all of Japan. Their food habits also differ from other parts of Japan. To obtain basic dietary information, we surveyed 21 centenarians in Okinawa (17 women and 4 men). The dietary survey was done by one 24h recall method, as was done for centenarians living throughout Japan (3). The energy intake of the Okinawan centenarians living at home was about 1, 100 kcal/day for both sexes, which was similar to that of centenarians throughout Japan. Energy, some nutrient intakes and food consumption pattern (in terms of food groups) were different from those of the centenarians throughout Japan. We also measured their heights, weights, hematological values and activities of daily living (ADL). Comparison between the nutrient intakes and the recommended dietary allowances (RDAs) estimated for the centenarians showed that the estimated RDA of energy for the Okinawan centenarians might be less than their actual intakes.