著者

井上 卓 新里 譲 Inoue Taku Shinzato Yuzuru 琉球大学院医学研究科臨床薬理学分野 沖縄赤十字病院循環器科

出版者

琉球医学会

雑誌

琉球医学会誌 = Ryukyu Medical Journal (ISSN:1346888X)

巻号頁・発行日

vol.27, no.3, pp.123-129, 2008

---

Background: Elevated heart rate is closely associated with cardiovascular morbidity, mortality and all-cause mortality. Elevated heart rate is also associated with cardiovascular risk factors. The aim of the present study was to evaluate whether elevated heart rate is associated with cardiovascular morbidity independent of cardiovascular risk factors. Methods & Results: We examined the association between heart rate and cardiovascular morbidity of ambulatory patients. Of 102 patients, 3 were excluded because of low ejection fraction. Among the remaining 99 subjects (54 men, 45 women, $66 pm 12$ years of age), 34 (20 men, 14 women, $ 71\pm 8$ years of age) had a history of cardiovascular disease. The subjects with cardiovascular disease were significantly older, and had lower systolic blood pressure and lower total cholesterol levels than those without cardiovascular disease. Multivanable logistic regression analysis adjusted for age, sex, and antihypertensive agents revealed that a 20 beats/min heart rate increase was associated with an approximately 4-fold increase in the risk for cardiovascular disease (OR 3.597, 95% CI 1.456 - 8.888, p=0.0055). Metabolic syndrome (OR 1.276, 95% CI 0.434 - 3.752, p=NS) and chronic kidney disease (OR 0.736, 95% CI 0.238 - 2.279, p=NS) were not associated with cardiovascular disease. After excluding the patients prescribed such heart rate-lowering drugs as $ \beta $ -antagonist or diltiazem, heart rate increase was still the only factor associated with the risk for cardiovascular disease ( OR3.692, 95% CI 1.123 - 12.137, p=0.0351). Conclusions: Elevated heart rate is closely associated with cardiovascular morbidity independent of other cardiovascular risk factors such as metabolic syndrome or chronic kidney disease.

著者

玉木 正人 下地 光好 久貝 忠男 大田 治 佐久田 斉 川畑 勉 鎌田 義彦 宮城 和史 赤崎 満 大嶺 靖 伊波 潔 国吉 幸男 古謝 景春 草場 昭 Tamaki Masato Shimoji Mituyoshi Kugai Tadao Ohta Osamu Sakuda Satoshi Kawabata Tsutomu Kamada Yoshihiko Miyagi Kazufumi Akasaki Mitsuru Ohmine Yasushi Iha Kiyoshi Kuniyoshi Yukio Koja Kageharu Kusaba Akira 琉球大学医学部外科学第二講座

出版者

琉球医学会

雑誌

琉球医学会誌 = Ryukyu Medical Journal (ISSN:1346888X)

巻号頁・発行日

vol.13, no.3, pp.321-327, 1993

被引用文献数

3

---

A case of schwannoma originating in the right intrathoracic vagus nerve was reported. A 72-yearold woman had an abnormal shadow in the right upper mediastinum on a chest roentgenogram. A CT scan and MRI revealed a tumor in the upper mediastinum compressing the trachea, right carotid artery and right subclavian artery. An incisional biopsyof the mass in the right neck was revealed to be benign schwannoma. The mass was 55 ×42×29mm in size and originated from the right vagusnerve at the proximal level and extended to the branch of the recur-rent laryngeal nerve. There was no evidence of invasion of the mass into the surrounding organsand tissues were evident. Subcapsular ex tirpation was done preserving the nerve fibers. However, postoperative hoarseness due to dysfunction of the recurrent laryngeal nerve occurred. Mediastinal schwannoma originating in the vagus nerve is notso common ; 29 cases have been reported in Japanese literature.