著者

潮平 英郎 仲松 正司 喜瀬 勇也 比嘉 太 健山 正男 外間 惟夫 国吉 幸男 植田 真一郎 中村 克徳 藤田 次郎

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.136, no.9, pp.1313-1317, 2016 (Released:2016-09-01)

参考文献数

16

被引用文献数

1 2

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Teicoplanin, a glycopeptide antibiotic for methicillin-resistant Staphylococcus aureus, is recommended for therapeutic drug monitoring during treatment. Maintaining a high trough range of teicoplanin is also recommended for severe infectious disease. However, the optimal dose and interval of treatment for severe renal impairment is unknown. We report a 79-year-old man who received long-term teicoplanin treatment for methicillin-resistant Staphylococcus aureus bacteremia due to postoperative sternal osteomyelitis with renal impairment. Plasma teicoplanin trough levels were maintained at a high range (20-30 μg/mL). Although the patient required long-term teicoplanin treatment, a further decline in renal function was not observed, and blood culture remained negative after the start of treatment. Teicoplanin treatment that is maintained at a high trough level by therapeutic drug monitoring might be beneficial for severe methicillin-resistant Staphylococcus aureus infection accompanied by renal impairment.

著者

玉木 正人 下地 光好 久貝 忠男 大田 治 佐久田 斉 川畑 勉 鎌田 義彦 宮城 和史 赤崎 満 大嶺 靖 伊波 潔 国吉 幸男 古謝 景春 草場 昭 Tamaki Masato Shimoji Mituyoshi Kugai Tadao Ohta Osamu Sakuda Satoshi Kawabata Tsutomu Kamada Yoshihiko Miyagi Kazufumi Akasaki Mitsuru Ohmine Yasushi Iha Kiyoshi Kuniyoshi Yukio Koja Kageharu Kusaba Akira 琉球大学医学部外科学第二講座

出版者

琉球医学会

雑誌

琉球医学会誌 = Ryukyu Medical Journal (ISSN:1346888X)

巻号頁・発行日

vol.13, no.3, pp.321-327, 1993

被引用文献数

3

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A case of schwannoma originating in the right intrathoracic vagus nerve was reported. A 72-yearold woman had an abnormal shadow in the right upper mediastinum on a chest roentgenogram. A CT scan and MRI revealed a tumor in the upper mediastinum compressing the trachea, right carotid artery and right subclavian artery. An incisional biopsyof the mass in the right neck was revealed to be benign schwannoma. The mass was 55 ×42×29mm in size and originated from the right vagusnerve at the proximal level and extended to the branch of the recur-rent laryngeal nerve. There was no evidence of invasion of the mass into the surrounding organsand tissues were evident. Subcapsular ex tirpation was done preserving the nerve fibers. However, postoperative hoarseness due to dysfunction of the recurrent laryngeal nerve occurred. Mediastinal schwannoma originating in the vagus nerve is notso common ; 29 cases have been reported in Japanese literature.