著者

Phan Le Thanh Huong Pham Thu Hien Nguyen Thi Phong Lan Tran Quang Binh Dao Minh Tuan Dang Duc Anh

出版者

National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

pp.JJID.2015.157, (Released:2015-11-13)

参考文献数

36

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This article has been retracted by the authors under the agreement between the Editor-in-Chief, Masayuki Saijo and authors.

著者

Shinji Fukushima Hitoshi Kikuchi Mitsunobu Miyazu Atsuo Hamada Kazunobu Ouchi Hiroki Takagi Hanako Mihara Toru Sasaki Hayato Oka Valerie Bosch-Castells Philipp Oster

出版者

National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

pp.JJID.2017.277, (Released:2018-06-29)

参考文献数

31

被引用文献数

6

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Meningococcal disease can cause significant disability and mortality. The quadrivalent meningococcal polysaccharide diphtheria toxoid conjugate vaccine (Men-ACWY-D) protects against invasive meningococcal disease caused by serogroups A, C, W, and Y. This phase III, open-label, single-arm, multicenter study evaluated the safety and immunogenicity of a single vaccine dose in healthy Japanese adults. The study enrolled 200 participants 2-55 years of age. Immunogenicity was assessed by quantifying seroprotection rates (the proportion of participants with antibody titers ≥1:128 against capsular polysaccharide from all 4 serogroups, measured 28 days after vaccination). Safety endpoints included occurrence, nature, time to onset, duration, intensity, relationship to vaccination, and outcome of solicited and unsolicited adverse events (AEs) and serious AEs (SAEs). Participants included 194 adults, 2 adolescents, and 4 children. Among adults, seroprotection rates for serogroups A, C, W, and Y were 91.2%, 80.2%, 89.1%, and 93.8%, respectively. Seroconversion rates (proportion of participants with pre-vaccination titers of <1:4 and a ≥4-fold rise from baseline) were 87.3%, 83.0%, 94.4%, and 96.4%, respectively. No immediate AEs or reactions, SAEs, or deaths were reported in any age group. Men-ACWY-D is well tolerated and immunogenic, eliciting antibodies against capsular polysaccharides from all 4 serogroups in Japanese adults.

著者

W. D. Tigertt G. W. Hunter III Ritchie L. S. Ritchie

出版者

National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

雑誌

Japanese Journal of Medical Science and Biology (ISSN:00215112)

巻号頁・発行日

vol.5, no.5, pp.357-385, 1952 (Released:2010-03-19)

参考文献数

45

被引用文献数

2 2

著者

Yuichi Fukui Seigo Ohkawa Hisashi Inokuma

出版者

National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

pp.JJID.2017.558, (Released:2018-04-27)

参考文献数

15

被引用文献数

7

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Anaplasma phagocytophilum DNA was detected from a dog with canine granulocytic anaplasmosis (CGA) in Japan. Phylogenetic analysis of the DNA using 16s rRNA, gltA, and groEL sequences revealed that the strain was nearly identical to A. phagocytophilum detected from Apodemus agrarius (black-striped field mouse) in China and Korea. This report is the first phylogenetic study on A. phagocytophilum from a CGA case in Japan.

著者

Yoshiko Somura Fuminori Mizukoshi Koo Nagasawa Kana Kimoto Mayuko Oda Takayuki Shinkai Koichi Murakami Kenji Sadamasu Kazuhiko Katayama Hirokazu Kimura

出版者

National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

pp.JJID.2017.264, (Released:2018-02-28)

参考文献数

10

被引用文献数

4

著者

Gaowa Wulantuya Xuhong Yin Minzhi Cao Shengchun Guo Chunlian Ding Lu Yuhua Luo Jianchang Hiroki Kawabata Shuji Ando Hongru Su Masahiko Shimada Naoya Takamoto Yuko Shimamura Shuichi Masuda Norio Ohashi

出版者

National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

pp.JJID.2017.450, (Released:2018-02-28)

参考文献数

15

被引用文献数

7

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Anaplasma phagocytophilum is an obligate intracellular bacterium and causes febrile illness in humans and livestock. A 49-year-old woman was suffering from feverish symptom, fatigue, arthralgia, general body pain, and anorexia for 2 weeks. Later, she visited Bayan Nur Centers for Disease Control and Prevention Hospital in Inner Mongolia, China. Molecular-based diagnostic analysis of the patient’s blood revealed that A. phagocytophilum p44 DNA was positive, but Brucella omp31, spotted fever group Rickettsia gltA, Orientia tsutsugamushi 16S rDNA, and Ehrlichia p28 were negative. The amino acid sequences of 9 A. phagocytophilum p44 clones obtained from the patient shared 44-100% similarity among them and closely related to those of previously-identified p44 clones from canis familiaris (accession no. KJV64194) and from Ixodes persulcatus tick (no. BAN28309). Serological tests using the patient’s serum showed that IgM and IgG titers to A. phagocytophilum antigens were 160 and 20, respectively, determined by indirect immunofluorescence assay and the reaction to recombinant P44 proteins (rP44-1, rP44-18ES, and/or rP44-47) were confirmed by Western blot analysis. Thus, the results obtained in this study strongly suggests that the patient was infected with A. phagocytophilum. To our knowledge, this is a first case of human anaplasomosis infection in Inner Mongolia autonomous region.

著者

Lattapon Suwanprinya Noppawan Phumala Morales Pimtip Sanvarinda Hamady Dieng Tamaki Okabayashi Ronald Enrique Morales Vargas

出版者

National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

vol.70, no.4, pp.383-387, 2017 (Released:2017-07-24)

参考文献数

33

被引用文献数

8

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Encephalitis has been described worldwide as a severe complication in patients infected by dengue virus. Reactive oxygen species (ROS) production is a key mechanism involved in the neuronal damage caused by viral encephalitis. In the present study, the capability of dengue virus serotypes 2 (DENV2) and DENV4 to induce ROS production was investigated in a rat microglial cell line, HAPI cells. The cells were infected with DENV2 and DENV4 at a multiplicity of infection of 0.1 for a 2-h adsorption period. Japanese encephalitis virus (JEV) was used as the reference. DENV2- and DENV4-induced microglial activation and significantly increased ROS production corresponded to decreased cell viability. The activity of DENV4 was significantly higher than the activities of DENV2 and JEV at 48 and 72 h post infection. DENV4 partly induced ROS production via an iron-induced Fenton reaction, as demonstrated by the treatment with an iron chelator, deferiprone. Despite the induction of increased inducible nitric oxide synthase expression and nitric oxide (NO) production by JEV, DENV2, and DENV4 did not induce NO production, suggesting the activation of different pathways in response to infections by different viruses. In conclusion, DENV2 and DENV4 have the capability to induce ROS production and activate microglia, which have been reported as the key components of neuronal damage.

著者

Hiroki Ozawa Shigeru Tajima Eri Nakayama Kengo Kato Akifumi Yamashita Tsuyoshi Sekizuka Makoto Kuroda Shuzo Usuku

出版者

National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

pp.JJID.2017.256, (Released:2017-12-26)

参考文献数

14

被引用文献数

3

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Zika virus (ZIKV) infection has been documented within Central and South America, Asia, and Africa. Here we report the isolation of virus from a patient infected with ZIKV returning to Japan from the Dominican Republic. The ZIKV strain was imaged by electron microscopy and its complete genome sequence was analyzed. Phylogenetic analysis and molecular characterization revealed that the strain was of the Asian lineage, and carried two unique mutations in its NS5 region. These mutations are characteristic of strains that originated in the Dominican Republic and the USA in 2016.

著者

JUNKICHIRÔ HIRADE MASATAKA KIKUNO NOBUYOSHI NAGAYA MASAYUKI SAITO

出版者

National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

雑誌

The Japanese Medical Journal (ISSN:1884281X)

巻号頁・発行日

vol.2, no.5, pp.263-265, 1950-03-30 (Released:2010-03-19)

参考文献数

4

著者

Sukehiro Nayu Kida Nori Umezawa Masahiro Murakami Takayuki Arai Naoko Jinnai Tsunesada Inagaki Shunichi Tsuchiya Hidetoshi Maruyama Hiroshi Tsuda Yoshio

出版者

National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

vol.66, no.3, pp.189-194, 2013

被引用文献数

41

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The invasion of the yellow fever mosquito <i>Aedes aegypti</i> at Narita International Airport, Japan was detected for the first time. During the course of routine vector surveillance at Narita International Airport, 27 <i>Ae. aegypti</i> adults emerged from larvae and pupae collected from a single larvitrap placed near No. 88 spot at passenger terminal 2 on August 8, 2012. After the appearance of <i>Ae. aegypti</i> in the larvitrap, we defined a 400-m buffer zone and started an intensive vector survey using an additional 34 larvitraps and 15 CO₂ traps. International aircraft and passenger terminal 2 were also inspected, and one <i>Ae. aegypti</i> male was collected from the cargo space of an international aircraft from Darwin via Manila on August 28, 2012. Larvicide treatment with 1.5% fenitrothion was conducted in 64 catch basins and one ditch in the 400-m buffer zone. Twenty-four large water tanks were also treated at least once with 0.5% pyriproxyfen, an insect growth regulator. No <i>Ae. aegypti</i> eggs or adults were found during the 1-month intensive vector survey after finding larvae and pupae in the larvitrap. We concluded that <i>Ae. aegypti</i> had failed to establish a population at Narita International Airport.

著者

Arata Hidano Yoko Hayama Toshiyuki Tsutsui

出版者

National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

vol.65, no.5, pp.396-402, 2012 (Released:2012-09-25)

参考文献数

23

被引用文献数

4 7

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Rabies was eliminated in Japan over 50 years ago; however, the recent increase in the movement of humans and animals across the world highlights the potential threat of disease reentry into the country. The immune status against rabies among the dog population in Japan is not well known; thus, the purpose of this study was to estimate the prevalence of dogs with effective immunity from the vaccination history using a web-based survey. We found that 76.9% (95% confidence interval, 75.8–78.1) of dogs in this study population belonged to the population in which 90% were assumed to have the internationally accepted antibody titer. We showed that dogs taken less frequently for walks were less likely to be vaccinated. Additionally, the frequency of encounters with other dogs during walks and the number of individuals in households were associated with vaccination history. To our knowledge, this study is the first report estimating the prevalence of dogs in Japan with effective immunity against rabies. Further, we identified the population with low vaccination coverage as well as the heterogeneous characteristics of vaccination history among the dog population. These findings contribute to the implementation of an efficient strategy for improving the overall vaccination coverage in Japan and the development of a quantitative risk assessment of rabies.