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CRISP_SCIENCE (@ScienceCrisp)

投稿一覧（最新100件）

1 0 0 0 OA Preface to the special issue “Current Status and Future Prospects for the Development of Crop Varieties and Breeding Materials Using Genome Editing Technology”

Preface to the special issue “Current Status and Future Prospects for the Development of Crop Varieties and Breeding Materials Using Genome Editing Technology” Nishihara M, Muranaka T. Plant Biotechnology. 2023-09-25. https://t.co/1hhb9cPCF6 3 reviews & 5 original papers; #CRISPR

2 0 0 0 OA Efficiency of potato genome editing: Targeted mutation on the genes involved in starch biosynthesis using the CRISPR/dMac3-Cas9 system

REVIEW "Efficiency of potato genome editing: Targeted mutation on the genes involved in starch biosynthesis using the #CRISPR/dMac3-Cas9 system" Kusano H, Takeuchi A, Shimada H. Plant Biotechnology. 2023-09-07. https://t.co/g8sOLhYvyN

2 0 0 0 OA Precise genetic engineering with piggyBac transposon in plants

REVIEW "Precise genetic engineering with piggyBac transposon in plants" Nishizawa-Yokoi A, Toki S. Plant Biotechnol J. 2023-08-28. https://t.co/ho8CKg2hR2 … for the induction of targeted mutagenesis via #CRISPR/Cas9 in plants https://t.co/aay3YnWnIC

2 0 0 0 CRISPR/Cas9を利用したゲノム編集の原理とアレルギー疾患への応用

"#CRISPR/Cas9を利用したゲノム編集の原理とアレルギー疾患への応用" 石野良純. アレルギー 2023 年 72 巻 4 号 p. 343-352. https://t.co/bu9mlJQ660

1 0 0 0 CRISPR-Cas9システムを用いた新規Aβ産生制御因子の同定と解析

[Identification of novel regulators involved in AD pathogenesis using the #CRISPR-Cas9 system] Tomizawa I, Chiu Y-W, Hori Y, Tomita T. Nihon Yakurigaku Zasshi. 2023;158(1):21-25. https://t.co/k14iih5T0w https://t.co/yA9lCQLh6w [in Japanese]

1 0 0 0 OA Feasibility Study of Dendrimer-Based TTR-CRISPR pDNA Polyplex for Ocular Amyloidosis in Vitro

"Feasibility Study of Dendrimer-Based TTR-#CRISPR pDNA Polyplex for Ocular Amyloidosis in Vitro" Inoue M [..] Jono H, Motoyama  K. Biol Pharm Bull 2022-11-01. https://t.co/WpOXWKaTdE

1 0 0 0 OA Amount of Cas9 protein introduced into mouse embryos via electroporation affects the genome-editing rate

"Amount of Cas9 protein introduced into mouse embryos via electroporation affects the genome-editing rate” Wake Y, Vakulskas CA, Glenn SE, Kaneko T. J Reprod Dev 2022-07-14. https://t.co/DGmqU8lv2b #CRSIPR; TAKE (Technique for animal knockout system by electroporation)

1 0 0 0 OA Examination of Cyp51A-Mediated Azole Resistance in Aspergillus lentulus Using CRISPR/Cas9 Genome Editing

Examination of Cyp51A-Mediated Azole Resistance in Aspergillus lentulus Using CRISPR/Cas9 Genome Editing. Tateno M, Umeyama T [..] Miyazaki Y. Med Mycology J 2022-02-16 https://t.co/wtDEdJGkq4 introduced the entire A. fumigatus cyp51A gene into the cyp51A locus in A. lentulus

1 0 0 0 OA Exploring the potential for CRISPR in Toxicology: An Introduction

"Exploring the potential for CRISPR in Toxicology: An Introduction" Davis M (Bristol Myers Squibb). https://t.co/7YATUzJSbl

1 0 0 0 OA Age-Dependent Echocardiographic and Pathologic Findings in a Rat Model with Duchenne Muscular Dystrophy Generated by CRISPR/Cas9 Genome Editing

"Age-Dependent Echocardiographic and Pathologic Findings in a Rat Model with Duchenne Muscular Dystrophy Generated by #CRISPR/Cas9 Genome Editing" Sugihara H, Kimura K [..] Komuro I. Int Heart J. 2020-11-13. https://t.co/fTdBmhIiRH

18 0 0 0 OA 原核生物の新規な獲得免疫機構CRISPR/Casシステム リピートとスペーサーの規則的反復構造が細菌の進化をコントロールする

RT @sugargroove: 化学と生物 @jsbba_katosei に載った2013年の記事 「原核生物の新規な獲得免疫機構CRISPR/Casシステム」 学生さんこれどうですか？ 私は素晴らしい解説だと思いますが、こういうのを本当に面白いと思って追求する研究者が多数…

1 0 0 0 OA A rapid method for detection of mutations induced by CRISPR/Cas9-based genome editing in common wheat

"A rapid method for detection of mutations induced by #CRISPR/Cas9-based genome editing in common wheat" Kamiya Y [..] Kawaura K. Plant Biotechnology 37, 247–251 (2020) https://t.co/8iQm04Smql Biolistic transient expression of the gRNAs and Cas9 ...

1 0 0 0 OA Generation of novel Il2rg-knockout mice with Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and Cas9

Generation of Novel Il2rg-Knockout Mice with #CRISPR-Cas9. Byambaa S, Uosaki H, Hara H, Nagao Y, Abe T, Shibata H, Nureki O, Ohmori T, Hanazono Y. Exp Anim. 2019-12-04. https://t.co/XvR3CQ3rhV "X-SCID model”

2 0 0 0 OA Suppression of mosaic mutation by co-delivery of CRISPR associated protein 9 and three-prime repair exonuclease 2 into porcine zygotes via electroporation

Suppression of mosaic mutation by co-delivery of #CRISPR associated protein 9 and three-prime repair exonuclease 2 into porcine zygotes via electroporation. Yamashita S, Kogasaka Y, Hiradate Y, Tanemura K, Sendai Y. J Reprod Dev. 2019-11-24. https://t.co/e69BiQNQH8

1 0 0 0 OA Efforts to enhance safety measures for CRISPR/Cas-based gene drive technology in Japan

Efforts to enhance safety measures for #CRISPR/Cas-based gene drive technology (CCGDT) in Japan. Tanaka T et al. Journal of Environment and Safety 2019-10-07 https://t.co/UXC5Qu21yw "Nationwide survey on CCGDT; potential risks of CCGDT are not understood by many researchers"

1 0 0 0 OA Monitoring single-cell bioluminescence of Arabidopsis leaves to quantitatively evaluate the efficiency of a transiently introduced CRISPR/Cas9 system targeting the circadian clock gene ELF3

Monitoring single-cell bioluminescence of Arabidopsis leaves to quantitatively evaluate the efficiency of a transiently introduced #CRISPR/Cas9 system targeting the circadian clock gene ELF3. Kanesaka Y, Okada M, Ito S, Oyama T. Plant Biotechnology. 2019 https://t.co/bqEVuFGKOQ

1 0 0 0 OA CRISPR/Cas9-mediated genome editing of Shewanella oneidensis MR-1 using a broad host-range pBBR1-based plasmid

#CRISPR/Cas9-mediated genome editing of Shewanella oneidensis MR-1 using a broad host-range pBBR1-based plasmid. Suzuki Y, Kouzuma A, Watanabe K. J Gen App Microbiol. 2019-08-23. https://t.co/76sdcaD5T1

1 0 0 0 OA Hairless-knockout piglets generated using the clustered regularly interspaced short palindromic repeat/CRISPR-associated-9 exhibit abnormalities in the skin and thymus

Hairless-knockout piglets generated using #CRISPR/Cas9 exhibit abnormalities in the skin and thymus. Gao QS, Xuan MF [..] Yin XJ. Exp Anim. Accepted 2019-02-15. https://t.co/JNizhcvRAd

8 0 0 0 OA Advances in CRISPR/Cas9 Technology for in Vivo Translation

[REVIEW] Advances in #CRISPR/Cas9 Technology for in Vivo Translation. Çiçek YA, Luther DC, Kretzmann JA, Rotello VM. Biol Pharm Bull. 2019-03-01. https://t.co/EyP0bnx77m "viral and non-viral delivery methods"

1 0 0 0 OA Effects of concentration of CRISPR/Cas9 components on genetic mosaicism in cytoplasmic microinjected porcine embryos

Effects of concentration of #CRISPR/Cas9 components on genetic mosaicism in cytoplasmic microinjected porcine embryo. Tanihara F [..] Otoi T. J Reprod Develop. 2019-02-05. https://t.co/ZJH05f9nLQ

1 0 0 0 OA AMED-BINDS(創薬等ライフサイエンス研究支援基盤プラットフォーム)の活動

AMED-BINDS (創薬等ライフサイエンス研究支援基盤プラットフォーム) の活動. 中村春木, 近藤裕郷 #PDIS 生物物理 2018-10-13. https://t.co/cr5zquqZA3

1 0 0 0 OA Enlargement of egg size by CRISPR/Cas9-mediated knockout of a sex-linked gene in the silkworm, Bombyx mori

Enlargement of egg size by #CRISPR/Cas9-mediated knockout of a sex-linked gene in the silkworm, Bombyx mori. Fujii T, Banno Y. J Insect Biotechnol Sericology. 2018. https://t.co/8I42su4tIU

21 0 0 0 OA Off- and on-target effects of genome editing in mouse embryos

RT @GaetanBurgio: 'Off- and on-target effects of #CRISPR genome editing in mouse embryos' -> in short off-target manageable in mice whereas…

2 0 0 0 OA Generation of the Adenovirus Vector-Mediated CRISPR/Cpf1 System and the Application for Primary Human Hepatocytes Prepared from Humanized Mice with Chimeric Liver

Generation of the Adenovirus Vector-Mediated #CRISPR/Cpf1 System and the Application for Primary Human Hepatocytes Prepared from Humanized Mice with Chimeric Liver. Tsukamoto T [..] Mizuguchi H. Biol Pharm Bull 2018 Jul 1. https://t.co/J3gC618YjB

1 0 0 0 OA Temporal Kinetics of Microgliosis in the Spinal Dorsal Horn after Peripheral Nerve Injury in Rodents

#PDIS Temporal Kinetics of Microgliosis in the Spinal Dorsal Horn after Peripheral Nerve Injury in Rodents. Kohno K [..] Tsuda M. Biol Pharma Bull 2018 Jul 1. https://t.co/QsVUlI4R7H

1 0 0 0 OA Metabolic Engineering of Escherichia coli KO11 with the NADH Regeneration System for Enhancing Ethanol Production

Metabolic Engineering of Escherichia coli KO11 with the NADH Regeneration System for Enhancing Ethanol Production. J Chem Eng Jpn 0320. #CRISPR https://t.co/gjXlT88MyM https://t.co/nzvDMgHHO7

3 0 0 0 OA Synthetic Studies on Heteropolycyclic Natural Products: Development of Divergent Strategy

#PDIS [REVIEW]Synthetic Studies on Heteropolycyclic Natural Products: Development of Divergent Strategy. Chem Pharm Bull. https://t.co/QtFmSNl4pO

1 0 0 0 Visualization of Chromatin Loci with Transiently Expressed CRISPR/Cas9 in Plants

Visualization of Chromatin Loci with Transiently Expressed #CRISPR/Cas9 in Plants Cytologia https://t.co/QEJxTtlknK

2 0 0 0 OA Creation of Novel Toxic Gas Surrogates and the Development of Safe and Facile Catalytic Reactions

[Review]Creation of Novel Toxic Gas Surrogates and the Development of Safe and Facile Catalytic Reactions Chem Pharm Bull 0101 https://t.co/oYPJPP9Tns

1 0 0 0 OA Solid-Phase Modular Synthesis of Park Nucleotide and Lipids I and II Analogues

#PDIS Solid-Phase Modular Synthesis of Park Nucleotide and Lipids I and II Analogues Chem Pharm Bull 0101 https://t.co/YTB2ObPkZp

2 0 0 0 OA Synthesis of Tetrahydrobiphenylene via Pd(0)-Catalyzed C(sp2)–H Functionalization

#PDIS Synthesis of Tetrahydrobiphenylene via Pd(0)-Catalyzed C(sp2)–H Functionalization Chem Pharm Bull 1201 https://t.co/ZARmS1Ta2B

1 0 0 0 OA Simple Synthesis of Sakuranetin and Selinone via a Common Intermediate, Utilizing Complementary Regioselectivity in the Deacetylation of Naringenin Triacetate

#PDIS Simple Synthesis of Sakuranetin and Selinone via a Common Intermediate, Utilizing Complementary Regioselectivity in the Deacetylation of Naringenin Triacetate Chem Pharm Bull https://t.co/ummsjstxIM

2 0 0 0 OA Synthesis of 1-Tetrasubstituted 2,2,2-Trifluoroethylamine Derivatives via Palladium-Catalyzed Allylation of sp3 C–H Bonds

#PDIS Synthesis of 1-Tetrasubstituted 2, 2, 2-Trifluoroethylamine Derivatives via Palladium-Catalyzed Allylation of sp3 C–H Bonds Chem Pharm Bull https://t.co/r5BFfM0DaC

1 0 0 0 OA Novel Non-steroidal Progesterone Receptor Ligands Based on m-Carborane Containing a Secondary Alcohol: Effect of Chirality on Ligand Activity

#PDIS Novel Non-steroidal Progesterone Receptor Ligands Based on m-Carborane Containing a Secondary Alcohol: Effect of Chirality on Ligand Activity Chem Pharm Bull https://t.co/JBui1On4zJ

1 0 0 0 OA Affinity Labeling with 4-Azidophthalimide (AzPI): Relation between Labeling Rate and Fluorescence Intensity

#PDIS Affinity Labeling with 4-Azidophthalimide (AzPI): Relation between Labeling Rate and Fluorescence Intensity Chem Pharm Bull https://t.co/6yFTGeKouN

1 0 0 0 OA 生体分子間相互作用を基盤とする機能分子の創製とケミカルバイオロジーへの展開

[レビュー]生体分子間相互作用を基盤とする機能分子の創製とケミカルバイオロジーへの展開 YAKUGAKU ZASSHI 1001 https://t.co/9jdGvxnohA

1 0 0 0 ユネスコ「ヒトゲノムと人権に関する世界宣言案」の調査・研究

ヒトゲノムと人権に関する世界宣言 https://t.co/4Nx2FBt3R9

1 0 0 0 OA 分子動力学計算を用いたトルテロジンのCYP3A4代謝部位予測

#PDIS CYP3A4の薬剤代謝部位（SOM）予測：カルバマゼピンで検証したドッキングとMDのシミュレーションによる手法を柔軟なトルテロジンに展開；MD の複数初期構造選択手法を吟味し、SOMと結合様式予測実現 CBIJ 0531 https://t.co/4HXa7kaRIi

2 0 0 0 OA WNKキナーゼ特異的阻害剤の新規リード化合物探索のためのドッキングシミュレーション

#PDIS 偽性低アルドステロン症の病因であるキナーゼ（WNK1とWNK4）の阻害剤候補を創薬機構のフラグメントライブラリーからスクリーン CBIジャーナル 0330 https://t.co/1T2gJHgOoO 0408 https://t.co/sharzx4THw

2 0 0 0 OA WNKキナーゼ選択的阻害剤のための競合フラグメントアッセイ

#PDIS 偽性低アルドステロン症の病因であるキナーゼ（WNK1とWNK4）の阻害剤候補を創薬機構のフラグメントライブラリーからスクリーン CBIジャーナル 0330 https://t.co/1T2gJHgOoO 0408 https://t.co/sharzx4THw

2 0 0 0 OA 二次元高分解能二次イオン質量分析装置(NanoSIMS)を用いた生物試料の元素イメージング

NanoSIMS https://t.co/lDIMKv8yj8 と15N標識したコレステロール結合蛋白質により、CHO細胞表面上"accessible"コレステロールの分布が微絨毛に偏在することを同定 PNAS 0206-0221 https://t.co/EBfgVn6Upe

1 0 0 0 OA Inhibition of CRISPR/Cas9-Mediated Genome Engineering by a Type I Interferon-Induced Reduction in Guide RNA Expression

CRISPR-Cas9送達はI型IFN産生を伴う自然免疫応答を誘起。今回、IFNαによってgRNAのコピー数が大きく減少し、その結果、indel変異がほぼ半減することが明らかに Biol Pharm Bull0301 https://t.co/XyR95WbYAM

1 0 0 0 OA 創薬等支援技術基盤プラットフォームで取り組む相関構造解析

一分子蛍光計測輝き、Integrative Structural Biology/相関構造解析https://t.co/zcaOIRebC7の一翼を担う：Nat Methods掲載２論文をハイライト　Nat Methods 0131 https://t.co/YWBpRkyTVM https://t.co/bOPHMmI02r

1 0 0 0 OA Modifying Cationic Liposomes with Cholesteryl-PEG Prevents Their Aggregation in Human Urine and Enhances Cellular Uptake by Bladder Cancer Cells

リポソームDDS：陽イオン性リポソームを、DSPE-PEG/DSG-PEGに替えコレステリル-PEGで修飾することで、ヒト尿における安定化・凝集防止と膀胱癌細胞内取込亢進を両立　#PDIS　Biol Pharm Bull 0201 https://t.co/GNpPmVttGY

1 0 0 0 OA Synthesis of Linezolid Metabolites PNU-142300 and PNU-142586 toward the Exploration of Metabolite-Related Events

バンコマイシン耐性菌に有効なオキサゾリジノン系抗菌薬リネゾリドが腎不全患者に血小板減少症をもたらす機構解明に有用：入手困難であった副作用の誘因であるリネゾリド代謝物２種類を合成 #PDIS Chem Pharm Bull 0201 https://t.co/GlcOyiSyrU

お気に入り一覧（最新100件）

1 0 0 0 OA 日本学術振興会の設立経緯をめぐって : 櫻井錠二による御進講「学術研究ノ振興」 (特集 戦前・戦中期における学術支援体制の形成)

理研や日本学術振興会の設立に貢献された櫻井錠二博士についてネットで調べていたら、昭和6年の天皇への御進講で、国が基礎理学研究と研究者をサポートすることの重要さを訴えた資料を見つけ、胸が熱くなった。その後150万円を下賜され、日本学術振興会設立にいたった。https://t.co/ABGFJnAZRw 1/

277 0 0 0 OA 分子系統解析の最前線

私が執筆した「分子系統学」の総説が出版になりました！ https://t.co/q0G3cJS3hE… 分子系統学の基礎から始まり、ソフトウェアの紹介、最近の議論のまとめなど、分子系統学に入門し、より良い系統樹推定をするために必要な知識をぎゅっとまとめています。ぜひ、ご一読いただけましたら幸いです。

18 0 0 0 OA 原核生物の新規な獲得免疫機構CRISPR/Casシステム リピートとスペーサーの規則的反復構造が細菌の進化をコントロールする

化学と生物 @jsbba_katosei に載った2013年の記事 「原核生物の新規な獲得免疫機構CRISPR/Casシステム」 学生さんこれどうですか？ 私は素晴らしい解説だと思いますが、こういうのを本当に面白いと思って追求する研究者が多数いてこその、いまのゲノム編集の隆盛があります。 https://t.co/CNr6EybaKw

フォロー（331ユーザ）の投稿一覧（直近7日間）

フォロワー（1782ユーザ）の投稿一覧（直近7日間）