鉛の代表的な血管毒性—内皮細胞の増殖阻害—のメカニズムであるパールカンの合成阻害を介在する細胞内シグナルを明らかにしました。 Lead suppresses perlecan expression via EGFR-ERK1/2-COX-2-PGI2 pathway in cultured bovine vascular endothelial cells https://t.co/BTohHPl9NO
Lead induces a metal transporter, ZIP8, via activation of the NF-κB signaling pathway and the induction is involved in the protection against lead cytotoxicity by intracellular lead accumulation independent mechanisms in cultured vascular endothelial cells https://t.co/nP9boowpCb