著者

内野 克喜 山村 喜一 齋藤 侑也 磯崎 貞夫 田村 善藏 中川 冨士雄 関根 一雄 小島 至

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.104, no.10, pp.1101-1107, 1984-10-25 (Released:2008-05-30)

参考文献数

15

被引用文献数

1 3

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We developed a simultaneous detection method of 9 kinds of diuretics in the urine by using thin-layer chromatographic (TLC) method and/or high-performance liquid chromatographic (HPLC) method. The diuretic drugs were extracted from the urine according to modified Tisdall et al. method by use of 1M phosphate buffer and ethylacetate. The TLC method was performed with a commercially available chromatographic plate containing mixed fluorescent substance and isopropyl alcohol-ammonia mixture as a development solvent. The HPLC method was accomplished with UV detection at 271nm. To examine the limit of detection of the methods, normal subjects were individually administered with commercially available tablets of 11 kinds of diuretics, 9 drugs were detected from 24 h urine of normal subjects. However, 2 drugs were not detected. By applying these methods to urine samples of female patients with hypokalemia, furosemide (FD) and trichlormethiazide (TCT) were detected. The chromatographic peak of FD on HPLC method was further assigned by mass spectrometry. The quantitative determination of TCT in the urine was also developed by HPLC method, and the urine concentration in a patient with self-administration of TCT was 0.80μg/ml.

著者

牧大 節子 相良 悦郎 中川 冨士雄

出版者

Japanese Society of Pharmaceutical Health Care and Sciences

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.4, no.3, pp.130-131, 1978

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The study was made on prescribed doses of 317 drug products for oral use which appeared frequently in 6, 594 inpatient prescriptions filled at the University of Tokyo Hospital in 28 days purposively selected from a period of 4 months from March to June 1976. The prescribed doses were compared with usual doses stated in the Pharmacopoeia of Japan and package inserts. The drug products prescribed within usual dose range composed 19.6% of the total products used, the drugs within and above usual dose range 24.3%, within and below 30.5%, within and above and below 20.2%, and out of usual dose range 5.4%. The percentage distribution agreed with a conjecture of pharmacists in practice.

著者

牧大 節子 相良 悦郎 中川 冨士雄

出版者

日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.4, no.3, pp.130-131, 1978-11-20

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The study was made on prescribed doses of 317 drug products for oral use which appeared frequently in 6,594 inpatient prescriptions filled at the University of Tokyo Hospital in 28 days purposively selected from a period of 4 months from March to June 1976. The prescribed doses were compared with usual doses stated in the Pharmacopoeia of Japan and package inserts. The drug products prescribed within usual dose range composed 19.6% of the total products used, the drugs within and above usual dose range 24.3%, within and below 30.5%, within and above and below 20.2%, and out of usual dose range 5.4%. The percentage distribution agreed with a conjecture of pharmacists in practice.

著者

中川 冨士雄

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.26, no.8, pp.783, 1990-08-01 (Released:2018-08-26)