著者

伊賀 淳一

出版者

愛媛大学

雑誌

基盤研究(C)

巻号頁・発行日

2015-04-01

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うつ病患者の白血球におけるセロトニントランスポーターの発現は上昇しており、プロモーターのDNAメチル化率は低下していることを確認した。幼少期のストレスの影響を今後検討する必要がある。このほか老年期においてうつ病との鑑別が重要となるアルツハイマー型認知症やレビー小体型認知症において血液から得られる診断バイオマーカーの検討を行い、TREM2、SNCA、INPP5、TOMM40、APOE、PINK1、ABCA7、MEF2C、DRD2の遺伝子発現やDNAメチル化率の変化について英語論文で報告することができた。今後も老年期うつ病と認知症の鑑別に役立つバイオマーカーの検索を行う予定である。

著者

山田 崇恭 西脇 眞二 伊賀 淳郎 泉井 一浩 吉村 允孝

出版者

一般社団法人 日本機械学会

雑誌

日本機械学会論文集 C編 (ISSN:03875024)

巻号頁・発行日

vol.75, no.759, pp.2868-2876, 2009-11-25 (Released:2017-06-09)

参考文献数

21

被引用文献数

1 2

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In structural designs considering thermal loading, to control thermal stress and minimize decreases in material strength at high temperatures, it is important to maximize the thermal diffusivity of structures, in addition to the usual maximization of stiffness that optimal designs achieve. This paper presents a new level set-based topology optimization method for thermal problems with generic heat transfer boundaries in a fixed design domain that includes design-dependent effects, using level set boundary expressions and the Finite Element Method. First, a topology optimization method using a level set model incorporating fictitious interface energy is briefly discussed. Next, an optimization problem is formulated using the concept of total potential energy to address the design of mechanical structures that aim to minimize the mean temperature of the structure under thermal loading. An optimization algorithm that uses the Finite Element Method when solving the equilibrium equation and updating the level set function is then constructed. Finally, several numerical examples are provided to confirm the utility of the proposed optimization method.

著者

山口 雅英 伊賀 淳 石原 薫 和田 大志郎 吉井 清明 末田 統

出版者

一般社団法人 電気学会

雑誌

電気学会論文誌B(電力・エネルギー部門誌) (ISSN:03854213)

巻号頁・発行日

vol.123, no.3, pp.402-411, 2003 (Released:2004-03-31)

参考文献数

21

被引用文献数

11 14

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In this paper we examine the merits that a practical photovoltaic system combining photovoltaic generation with storage batteries would provide if used in ordinary residences. Various configurations and operation methods could be envisaged for such a system. In this research we examined the optimal battery capacity, operation methods, and economic effects for a system emphasizing economical merits for the user. We first calculated the hourly amount of photovoltaic generated electricity each month, and used data on average load patterns from actual measurements to calculate battery capacity. Next, taking battery capacity and photovoltaic module capacity/price as parameters, we calculated and evaluated the economic merits for ordinary residences. The results showed that the optimal battery capacity for combination with 3 or 5 kW photovoltaic generation is around 10 kWh, and that a combined system provides merits even though it entails higher photovoltaic module costs than the use of photovoltaic generation alone.