著者

内田 博之 小林 瑞希 細渕 亜実 太田 彩乃 大竹 一男 八巻 努 内田 昌希 小田切 陽一 夏目 秀視 小林 順

出版者

日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.69, no.3, pp.215-224, 2014 (Released:2014-09-24)

参考文献数

55

被引用文献数

1 9

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Objectives: We aimed to determine the effects of age, period, and birth cohort on cervical cancer mortality rate trends in Japanese women, by age-period-cohort (APC) analysis. Additionally, we analyzed projected mortality rates. Methods: We obtained data on the number of cervical cancer deaths in Japanese women from 1975–2011 from the national vital statistics and census population data. A cohort table of mortality rate data was analyzed on the basis of a Bayesian APC model. We also projected the mortality rates for the 2012–2031 period. Results: The period effect was relatively limited, compared with the age and cohort effects. The age effect increased suddenly from 25–29 to 45–49 years of age and gently increased thereafter. An analysis of the cohort effect on mortality rate trends revealed a steep decreasing slope for birth cohorts born from 1908–1940 and a subsequent sudden increase after 1945. The mortality rate projections indicated increasing trends from 40 to 74 years of age until the year 2031. Conclusions: The age effect increased from 25–29 years of age. This could be attributable to the high human papilloma virus (HPV) infection risk and the low cervical cancer screening rate. The cohort effect changed from decreasing to increasing after the early 1940s. This might be attributable to the spread of cervical cancer screening and treatment before 1940 and the high HPV infection risk and reduced cervical cancer screening rate after 1945. The projected mortality rate indicated an increasing trend until the year 2031.

著者

内田 昌希 浦山 玲菜 一色 恭徳 八巻 努 前野 拓也 上田 秀雄 近藤 誠一 夏目 秀視

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.40, no.2, pp.109-116, 2014-02-10 (Released:2015-02-10)

参考文献数

19

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In the present study, 0.5% povidone-iodine solution was prepared aseptically using various commercial products of 10% povidone-iodine solution, and the stability of 0.5% povidone-iodine solution after storage under various conditions was evaluated. Furthermore, a comparison between various commercial products was also performed. As a result, the stability of available iodine in 0.5% povidone-iodine solution was found to be affected by light, temperature and the sealability of the container. Of the storage methods investigated in the present study, the method of keeping the highest available iodine concentration was to store the povidone-iodine solution in a closed container under a light-shielded state at 4°C. The term of validity was 3 or 4 weeks in Hisiiode disinfectant solution or other products (Isodine® solution, Popiyodon solution, Negmin® solution, Popyral disinfectant solution and Iodine M disinfectant solution), respectively in storage in a closed container under a light-unshielded state at room temperature, which was the usual method of a disinfectant, from the results of a stability test of available iodine in 0.5% povidone-iodine solution. It was confirmed that bactericidal activity was maintained until at least 4 weeks after preparation in every commercial product from the results of a bactericidal activity test on the solution in the usual storage method (Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Aspergillus niger, Candida albicans). Of the 0.5% povidone-iodine solution investigated in the present study, Popiyodon solution and Negmin® solution kept the available iodine comparatively stable under each storage condition.