著者

加来 鉄平 鈴木 美威瑠 冨永 隆生 小川 暁郎 清水 厚志 渡邉 和孝 渡邉 和晃 前田 智司 松田 佳和

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.142, no.3, pp.289-293, 2022-03-01 (Released:2022-03-01)

参考文献数

11

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In recent years, lifestyle-related diseases such as hypertension and diabetes have been on the rise. These conditions can cause serious conditions such as myocardial and cerebral infarctions. Therefore, proper control of blood pressure and blood glucose levels is important issues in preventive medicine. Traditional fermented foods have been shown to have various functions, and their effects on lifestyle-related diseases have attracted particular attention. In this study, we investigated the effects of fermented soybeans and rice bran (OE-1) and supplements containing OE-1 on blood glucose levels and weight changes. We identified an inhibitory effect on elevated blood glucose levels upon administration of OE-1, and this effect was thought to be due to digestive enzyme inhibition. These effects of foods containing OE-1 are expected to have a positive effect on the prevention and improvement of lifestyle-related diseases as health foods.

著者

前田 智司 千葉 健史 浦丸 直人

出版者

日本薬科大学

雑誌

基盤研究(C)

巻号頁・発行日

2017-04-01

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母乳中のセロトニン(5-HT)およびノルアドレナリン(NA)の母乳産生および乳児に対する役割の解明を行った。母乳中の5-HTの経時的変動についての検討では、初乳、出産後1ヵ月、3ヵ月では母乳中の5-HTの含有量にほぼ同程度であった。母乳産生を担う乳腺上皮細胞は、NAを自ら合成し、母乳中へ分泌していることを明らかにした。さらに、授乳期にストレスを受けたマウスでは、母乳のNAが上昇し、β-カゼインを減少させることが分かった。これらの結果から母乳中に含まれている生理活性物質は母乳産生および乳児の成長に関与している可能性が示唆された。

著者

千葉 健史 前田 智司 平舩 寛彦 工藤 賢三

出版者

Japanese Society of Drug Informatics

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.19, no.4, pp.195-204, 2018 (Released:2018-03-21)

参考文献数

20

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Limited available information suggests that some drugs prescribed to pregnant and nursing women may influence the development of the mammary gland and the function of milk production during pregnancy and lactation, resulting in disturbance of breastfeeding.  The objective of the present study was to investigate the safety of these drugs, as well as to assess the presence of safety information regarding their effect on the fetus, the infant, mammary gland development and milk production, within the Ethical Drug Package Inserts (EDPI), the Drugs in Pregnancy and Lactation (DPL), and the Drugs and Lactation Database (LactMed).  Thirty-one drugs were prescribed to 24 pregnant women in Iwate Medical University Hospital.  None of these drugs provided information on the safety of the fetus in the EDPI, while 22 drugs provided this information in the DPL.  No information was provided in any of the 31 drugs regarding their influence on mammary gland development in the EDPI and DPL.  Sixteen drugs were prescribed to 40 nursing women in Iwate Medical University Hospital.  None of these drugs provided information regarding the safety of the infant in the EDPI, while this information was provided in the DPL of 10 drugs and in LactMed of 4 drugs, respectively.  No information regarding the effects on milk production was provided in the EDPI of any of the 16 drugs, while this information was present in the DPL for one drug and in LactMed for 4 drugs.  In conclusion, safety information of drugs about their potential adverse effects on the fetus and the infant, as well as on mammary gland development and milk production, should be included in multiple sources, including EDPI, DPL, and LactMed.  Notably, very few sources provide information on the influence of drugs on mammary gland development and milk production and this information should be enriched in future.