著者

富田 隆 幸田 幸直 工藤 賢三

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.138, no.3, pp.353-356, 2018-03-01 (Released:2018-03-01)

参考文献数

5

被引用文献数

1 4

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For patients with dysphagia in medical facilities and nursing homes, food thickeners are routinely used to aid the ingestion of medicines such as tablets. However, some types of thickeners affect the disintegration and dissolution of tablets, such as rapidly-disintegrating magnesium oxide tablets and donepezil hydrochloride orally disintegrating tablets. Additionally, delayed disintegration and dissolution of tablets affect a drug's efficacy. As an example, with Voglibose orally disintegrating tablets, marked differences are observed in changes in glucose levels during glucose tolerance testing. When using food thickeners to aid tablet ingestion, it is therefore necessary to select a product that has little effect on drug disintegration, dissolution, and activity.

著者

太田 若菜 櫻田 大也 小林 江梨子 平舩 寛彦 千葉 健史 富田 隆 工藤 賢三 佐藤 信範

出版者

一般社団法人 レギュラトリーサイエンス学会

雑誌

レギュラトリーサイエンス学会誌 (ISSN:21857113)

巻号頁・発行日

vol.8, no.2, pp.95-102, 2018 (Released:2018-05-31)

参考文献数

14

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後発医薬品への 「変更不可処方箋」 について調査を行った. 2017年1~3月の任意の1週間における, 岩手県薬剤師会に所属する233店舗の薬局で受け付けた処方箋75,513枚のうち, 変更不可処方箋は7,926枚 (10.50%) であった. 変更不可の指示件数は合計17,536件であり, 当該医薬品は1,714品目であった. そのうち後発医薬品のある先発医薬品が52.70%, 後発医薬品の銘柄指定が14.86%であった. 薬効分類別にみると, 循環器官用薬, 中枢神経系用薬, 消化器官用薬が上位を占めた. 変更不可の理由としては, “患者の希望” が最も多く, “医師の意向”, “薬剤変更により疾病コントロール不良・副作用の発現” などが続いた. 後発医薬品のさらなる使用推進には, 変更不可処方箋を減少させていくことが必要である. そのためには, 後発医薬品の品質向上や適切な情報提供だけでなく, 処方箋発行システムや診療報酬の面においても対策が必要である. 今後, 複数の地域で一定期間の処方箋抽出調査などを行い, 変更不可処方箋が後発医薬品の使用推進に与える影響についてさらに検討していく必要があると考えられる.

著者

富田 隆 工藤 賢三

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.53, no.6, pp.535-539, 2017 (Released:2017-06-01)

参考文献数

8

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医療施設や介護施設では,嚥下障害をもつ患者や入所者の誤嚥を防止するため,食事や服薬の際にとろみ調整食品が繁用されている.最近,薬剤服用時のとろみ調整食品の使用は,製剤の崩壊や溶出に影響をおよぼすことが分かってきた.本稿は,とろみ調整食品が,速崩壊性錠剤の崩壊,溶出,薬効におよぼす影響について,筆者らの検討事例を提示し,錠剤服用時のとろみ調整食品使用の参考資料として供するものである.

著者

佐藤 淳也 大久保 春香 佐々木 ゆうき 横井 誠 荻野 沙也佳 工藤 賢三

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.43, no.6, pp.328-335, 2017-06-10 (Released:2018-06-10)

参考文献数

17

被引用文献数

1 2

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Urine containing anticancer drugs may be scattered outside the toilet bowl during urination, and these drugs may be spread when they are stepped on. The scattering of urine droplets is dependent on the shape of the toilet bowl, contact point of the urine with the toilet bowl, and the posture assumed for urination. However, this concept has not been well investigated. In this study, we investigated the scattering of urine using fluorescent dye in a urinal and a Western-style toilet.To represent urination in the standing position, we sprayed a fluorescein solution on the wall or the bottom of a urinal. We modeled urination in the standing and sitting positions in a Western-style toilet by spraying fluorescein into the toilet bowl and in three spots around the toilet bowl. The number of droplets, area, scattering distance, and scattering area around the toilet bowl were measured optically.The droplet scattering was more extensive around the toilet bowl when the liquid was aimed at the bottom of the urinal and the front edge bottom of the water in the Western-style toilet. There was no droplet scattering when using the Western-style toilet in the sitting position.If a male patient receiving chemotherapy urinates in the standing position, the anticancer drug will spread through scattered urine and become an environmental pollutant. Therefore, it is important to instruct male patients to urinate in a sitting position when using a Western-style toilet.

著者

松尾 泰佑 富田 隆 工藤 賢三 佐塚 泰之

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.45, no.1, pp.54-60, 2019-01-10 (Released:2020-01-10)

参考文献数

9

被引用文献数

1

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Magnesium oxide tablets are sometimes crushed prior to administration to patients having difficulties in swallowing tablets. However, the quality of magnesium oxide formulations may decrease when stored for a long time as a one-dose package, owing to the absorption of high amounts of moisture by magnesium oxide. Additionally, as magnesium oxide solution is alkaline, it can interact with other medicines, making it incompatible for one-dose packaging. There are three types of magnesium oxide powder formulations: crushed magnesium oxide tablets, magnesium oxide bulk powder, and magnesium oxide granules. However, the appropriate formulation of magnesium oxide for one-dose packages is unknown. The stability of powder formulations stored as one-dose packages at 75% RH for 3 months was evaluated by analyzing the change in weight change and dissolution. The dissolution of the three powder formulations did not change for 3 months. Although the weight had increased in all the formulations, the change in the weight of magnesium oxide granules was the lowest among the three formulations. Isoniazid and levodopa tablets have been reported to interact with magnesium oxide tablets. The incompatibility between the crushed powder of these medicines and magnesium oxide powder formulations was analyzed when stored as one-dose packages. Among the three formulations, incompatibility was the lowest for granule. In conclusion, preserving magnesium oxide and other formulations that causes incompatibility should basically be avoided. However, magnesium oxide granules can be used for storing with the other formulations that interact with magnesium oxide within a term to circumvent incompatibility.

著者

松尾 泰佑 富田 隆 工藤 賢三 佐塚 泰之

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.44, no.9, pp.464-470, 2018-09-10 (Released:2019-09-10)

参考文献数

8

被引用文献数

6

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Tablet splitting, an important task of the pharmacist, is performed at hospitals and health insurance pharmacies. Although magnesium oxide tablets have no score line, the accuracy of their division is not assured. Furthermore, as magnesium oxide strongly absorbs moisture, the stability of half-tablets is unknown when stored in one-dose packages. The variation and loss when splitting magnesium oxide 500 mg tablets by using a tablet-divider were evaluated. The stabilities of split tablets after storage in one-dose packages at 75%RH were evaluated through the analysis of weight change, disintegration, and dissolution. The variation in half-tablets of magnesium oxide 500 mg tablets was 5.5 ± 4.4% and the loss of almost all tablets was below 1%. Although the weight of the half-tablets increased when preserved in one-dose packages, this was related to the quantity of magnesium oxide stored in one-dose packages and not on the splitting of tablets. The disintegration time of half-tablets was prolonged by increased moisture absorption, but the disintegration time of split tablets was shorter than that of whole tablets when the same quantity of moisture was absorbed. The dissolution rate was similar among split tablets and whole tablets. Magnesium oxide tablets can be administrated as a split tablet, but caution should be exercised regarding prolonged disintegration time. Pharmacists should be careful when using half-tablets in prescriptions.

著者

千葉 健史 前田 智司 平舩 寛彦 工藤 賢三

出版者

Japanese Society of Drug Informatics

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.19, no.4, pp.195-204, 2018 (Released:2018-03-21)

参考文献数

20

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Limited available information suggests that some drugs prescribed to pregnant and nursing women may influence the development of the mammary gland and the function of milk production during pregnancy and lactation, resulting in disturbance of breastfeeding.  The objective of the present study was to investigate the safety of these drugs, as well as to assess the presence of safety information regarding their effect on the fetus, the infant, mammary gland development and milk production, within the Ethical Drug Package Inserts (EDPI), the Drugs in Pregnancy and Lactation (DPL), and the Drugs and Lactation Database (LactMed).  Thirty-one drugs were prescribed to 24 pregnant women in Iwate Medical University Hospital.  None of these drugs provided information on the safety of the fetus in the EDPI, while 22 drugs provided this information in the DPL.  No information was provided in any of the 31 drugs regarding their influence on mammary gland development in the EDPI and DPL.  Sixteen drugs were prescribed to 40 nursing women in Iwate Medical University Hospital.  None of these drugs provided information regarding the safety of the infant in the EDPI, while this information was provided in the DPL of 10 drugs and in LactMed of 4 drugs, respectively.  No information regarding the effects on milk production was provided in the EDPI of any of the 16 drugs, while this information was present in the DPL for one drug and in LactMed for 4 drugs.  In conclusion, safety information of drugs about their potential adverse effects on the fetus and the infant, as well as on mammary gland development and milk production, should be included in multiple sources, including EDPI, DPL, and LactMed.  Notably, very few sources provide information on the influence of drugs on mammary gland development and milk production and this information should be enriched in future.

著者

平舩 寛彦 高橋 宏彰 千葉 健史 菅原 敦子 木村 祐輔 工藤 賢三 若林 剛 高橋 勝雄

出版者

日本緩和医療学会

雑誌

Palliative Care Research (ISSN:18805302)

巻号頁・発行日

vol.7, no.2, pp.395-402, 2012 (Released:2012-10-18)

参考文献数

18

被引用文献数

2

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【目的】本研究では, がん患者の栄養状態とフェンタニル経皮吸収性との関連性について検討を行った. 【方法】栄養スクリーニングツールのMalnutrition Universal Screening Tool (MUST)およびNutritional Risk Screening 2002 (NRS2002)を用いてがん患者の栄養状態を危険度別に分類し, 各群のフェンタニル皮膚移行率(FE)を比較した. 【結果】対象患者24名のMUSTによる分類(低, 中, 高度群)では, 栄養危険度が高い患者ほどFEが低くなる傾向にあり, NRS2002による分類(低, 高リスク群)では, 高リスク群のFEは低リスク群に比べて有意に低かった. 【結論】栄養状態の変化は, FEに影響を及ぼす要因の1つとなることが示唆された. また, 栄養状態が低下している患者では, フェンタニル経皮吸収性が低下している可能性があると考えられた.