3 0 0 0 OA スギ花粉症に対する初期療法
- 著者
- 北村 嘉章 水口 博之 福井 裕行 武田 憲昭
- 出版者
- JAPAN SOCIETY OF IMMUNOLOGY AND ALLERGOLOGY IN OTOLARYNGOLOGY
- 雑誌
- 耳鼻咽喉科免疫アレルギー (ISSN:09130691)
- 巻号頁・発行日
- vol.37, no.4, pp.241-244, 2019 (Released:2019-12-27)
- 参考文献数
- 20
2 0 0 0 OA カプサイシン軟膏による外耳道刺激は高齢認知症患者の肺炎を予防する
- 著者
- 陣内 自治 大西 皓貴 近藤 英司 川田 育二 坂東 弘康 岡本 秀彦 東 貴弘 佐藤 豪 北村 嘉章 阿部 晃治 武田 憲昭
- 出版者
- 一般社団法人 日本耳鼻咽喉科頭頸部外科学会
- 雑誌
- 日本耳鼻咽喉科頭頸部外科学会会報 (ISSN:24365793)
- 巻号頁・発行日
- vol.124, no.9, pp.1317-1318, 2021-09-20 (Released:2021-10-01)
- 著者
- 菅原 孝太郎 北村 嘉章 佐竹 真幸 村田 道雄 橘 和夫
- 出版者
- 天然有機化合物討論会実行委員会
- 雑誌
- 天然有機化合物討論会講演要旨集
- 巻号頁・発行日
- vol.53, pp.433-438, 2011
Our continuous efforts for search of new bioactive compounds led to isolation of a polyene-polyol, prorocentrol, from P. hoffmannianum (CCMP 683). Although a ketone-hemiacetal tautomerism was observed during the course of NMR measurements, NMR measurements in pyridine-d_5/D_2O (6:1) at room temperature gave simplified NMR spectra. Detailed COSY and TOCSY analyses led to four 114 spin-networks, which were constructed to gross structure on the basis of HMBC correlations. The stereoconfigurational analysis of prorocentrol was undertaken by extensive utilization of 2D-NMR methods. The conformation of cyclic ethers in the molecule was analyzed based on NOESY correlations and ^3J_<H,H・> A JBCA method was applied for elucidation of the relative configurations of chiral centers in acyclic portions. Where HETLOC did not give sufficient intensity, qualitative utilization of the relationship between HMBC signal intensity and corresponding ^<2,3>J_<C,H> turned out to be effective especially for the methyl bearing portions. Moreover, the universal NMR database method was also applied on the continuous polyol segments as an alternative way for the JBCA to reveal the relative configuration. As a particular property of prorocentrol, suggestive evidences for an association of prorocentrol and okadaic acid were indicated from chromatographic behaviors and changes of NMR chemical shifts.