著者

富山 俊一

出版者

日本医科大学医学会

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.70, no.3, pp.212-218, 2003 (Released:2003-06-25)

参考文献数

49

被引用文献数

2 2

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Since the report of Duke in which an allergic etiology was considered to be the cause of Meniere's disease, the hypothesis that a certain type of Meniere's disease is generated through immuno-pathological mechanisms has been advocated for 70 years. During this period, another entity of immune-mediated inner ear disorders, i. e., autoimmune inner ear disease was introduced. Fundamental immunological phenomena of the inner ear have been rapidly elucidated since 1980. The endolymphatic sac is the only site which contains immuno-competent cells within the inner ear. The inner ear is capable of mounting active immune responses when appropriately stimulated and the endolymphatic sac plays an integral function for inner ear immune response. Acutally, many reports have been published that link immunity and Meniere's disease with a variety of proposed immune-related etiologies from autoimmunity to non-autoimmunity. It is suggested that immune injury to the endolymphatic sac plays an important role in the pathogenesis of Meniere's disease. These functional and morphological circumstances strongly suggest that an immunological etiology of Meniere's disease is not theoretically unfounded.

著者

永井 賀子 小川 恭生 萩原 晃 大塚 康司 稲垣 太郎 河口 幸江 鈴木 衞 富山 俊一

出版者

一般社団法人 日本めまい平衡医学会

雑誌

Equilibrium Research (ISSN:03855716)

巻号頁・発行日

vol.74, no.2, pp.58-65, 2015-04-30 (Released:2015-06-01)

参考文献数

23

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Autoimmune inner ear disease (AIED) was reported by McCabe in 1979 and was characterized by episodic vertigo and fluctuating hearing loss. Some patients develop total deafness and severe disequilibrium which disturbs their activities of daily living (ADL). Steroids or immune suppressing agents are used to control symptoms, but they have to be given repeatedly, because the symptoms tend to recur. We analyzed 22 AIED patients diagnosed by the presence of a 68kDa protein. The patients with low grade hearing loss showed some recovery of their hearing, However, hearing recovery was not noted in any patient with severe hearing loss. It is important to diagnose AIED and start treatment as soon as possible.

著者

陣内 賢 富山 俊一 八木 聰明

雑誌

Otology Japan (ISSN:09172025)

巻号頁・発行日

vol.6, no.4, 1996-09-05

著者

奥田 稔 富山 俊一 大西 正樹 平良 晋一 宇井 浩一

出版者

耳鼻と臨床会

雑誌

耳鼻と臨床 (ISSN:04477227)

巻号頁・発行日

vol.41, no.2Supplement1, pp.326-341, 1995-03-20 (Released:2013-05-10)

参考文献数

15

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アレルギー性鼻炎症状を有するボランティアを対象にR50547点鼻剤を投与し, 本剤の薬物動態および鼻誘発反応に対する効果を検討した.薬物動態を検討した結果, 0.1および0.2mg投与時のt1/2およびTmaxは, 健常人で行われた単回投与試験結果とほぼ一致していた.鼻誘発反応に対する本剤の抑制効果を検討した結果, 有効率 (有効以上の%) が50%以上であつた持続時間は, 0.05, 0.1および0.2mg投与群でそれぞれ8, 8および12時間であつた. これら有効率の持続時間から, 本剤の至適投与回数は, 0.05および0.1mgでは1日2~3回, 0.2mgでは1日2回と推察された.以上より, R50547点鼻剤の鼻誘発反応に対する抑制効果が認められ, 本剤がアレルギー性鼻炎に対し, 少ない投与回数で効果が持続できる有用な薬剤である可能性が示唆された.