- Japan Otological Society
- Otology Japan (ISSN:09172025)
- vol.18, no.1, pp.39-44, 2008-03-21 (Released:2011-06-17)
Gentian violet (Pyoktanin) is known to have a potent antibacterial activity against Gram-positive bacteria including methicillin-resistantStaphylococcus aureus (MRSA).From November 2000 to August 2006, we have treated 91 patients for intractable ear infected with MRSA by topical treatment with gentian violet. There were 99 infected ears: 44 chronic otitis media, 11 otitis media with effusion treated with tympanostomy tube, 10 repetitive suppurative otitis media, 10 otitis externa, 8 postoperative discharging mastoid cavity for cholesteatoma, 6 cholesteatoma, 4 eosinophilic otitis media, 3 acute otitis media, 3 myringitis. The pathogens detected in those ears during the treatment period were as follows: MRSA in 92 ears, MRSA andP. aeruginosa7 ears. Topical treatment with gentian violet was performed 7.5 times on average. In the 92 ears (92.9%), topical treatment was performed 5.4 times on average. Noteworthily, 23 ears required only one treatment and 16 ears required twice, and this fact was suggesting that frequent treatments were not necessary to control the pathogens sensitive to gentian violet. This high cure rate (92/99) of the ear infected with MRSA also suggested that this treatment was especially effective for the treatment of MRSA infected ears.