著者

赤城 ゆかり 山中 昇 林 泰弘 九鬼 清典 寒川 高男 木村 貴昭

出版者

日本口腔・咽頭科学会

雑誌

口腔・咽頭科 (ISSN:09175105)

巻号頁・発行日

vol.6, no.2, pp.7-12, 1994-02-28 (Released:2010-06-28)

参考文献数

8

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Palmoplantar pustulosis (PPP) has been accepted as one of the secondary diseases caused by tonsillar focal infection ; however, the pathogenesis is still unknown. In this study, the expression of adhesion molecules on the palmar and plantar skin of eight patients with PPP and three healthy volunteers with normal skin were examined immunohistochemically. In normal skin, only CD44 was expressed on the epidermis. In the macroscopically normal region of PPP skin, intercellular adhesion molecule-1 (ICAM-1) was demonstrated on the endothelial cells in the dermis. In the erythema stage and the pustule stage, CD3, CD4, and lymphocyte function-associated antigen-1 (LFA-1) were expressed on the cells infiltrating the dermis. ICAM-1 was detected immunohistochemically on the endothelial cells, keratinocytes and infiltrating cells in PPP skins. Moreover, endothelial cell-leukocyte adhesion molecule-1 (ELAM-1) was expressed on vessels in the dermis in these two stages. These findings suggest that the interaction between LFA-1 and ICAM-1 plays an important role in T cell infiltration into PPP skin and that the continuity of ICAM-1 expression is related to the chronicity of PPP.

著者

木村 貴昭 山中 昇 九鬼 清典 林 泰弘 斉藤 匡人 木下 和也 田村 真司 赤城 ゆかり 山本 良一 玉置 かおり 高野 郁晴 保富 宗城 戸川 彰久 山室 日出子 島田 純 藤原 啓次 寒川 高男 神人 崇

出版者

The Society of Practical Otolaryngology

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.90, no.1, pp.121-130, 1997-01-01

被引用文献数

2

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A comparative study was performed for the purposes of studying the prophylactic effectiveness of an antecedent treatment for Japanese cedar pollinosis with DAREN^® (emedastine difumarate), an anti-allergic drug. Thirty-five cases (A group) received the drug at 4mg/day at least 2-4 weeks before the day when the pollen began to scatter. Another thirty-nine patients received the treatment after the scattering (B group). A significant inter group difference was observed in the global improvement rate for pollinosis. These findings suggest that DAREN^® produces a slow, long-acting effect such as the inhibition of the release of chemical mediators. Prophylactic medication seems to be suitable for the treatment of Japanese cedar pollinosis, because sufficient anti-allergic action is obtained a few weeks later. Side effects occurred in 6.9% of all of the cases, but the incidence was lower than with any other anti-allergic drug previously reported.<br>In summary, a prophylactic treatment with DAREN^® is effective in treating Japanese cedar pollinosis.