- 著者
-
木村 貴昭
山中 昇
九鬼 清典
林 泰弘
斉藤 匡人
木下 和也
田村 真司
赤城 ゆかり
山本 良一
玉置 かおり
高野 郁晴
保富 宗城
戸川 彰久
山室 日出子
島田 純
藤原 啓次
寒川 高男
神人 崇
- 出版者
- The Society of Practical Otolaryngology
- 雑誌
- 耳鼻咽喉科臨床 (ISSN:00326313)
- 巻号頁・発行日
- vol.90, no.1, pp.121-130, 1997-01-01
- 被引用文献数
-
2
A comparative study was performed for the purposes of studying the prophylactic effectiveness of an antecedent treatment for Japanese cedar pollinosis with DAREN<sup>®</sup> (emedastine difumarate), an anti-allergic drug. Thirty-five cases (A group) received the drug at 4mg/day at least 2-4 weeks before the day when the pollen began to scatter. Another thirty-nine patients received the treatment after the scattering (B group). A significant inter group difference was observed in the global improvement rate for pollinosis. These findings suggest that DAREN<sup>®</sup> produces a slow, long-acting effect such as the inhibition of the release of chemical mediators. Prophylactic medication seems to be suitable for the treatment of Japanese cedar pollinosis, because sufficient anti-allergic action is obtained a few weeks later. Side effects occurred in 6.9% of all of the cases, but the incidence was lower than with any other anti-allergic drug previously reported.<br>In summary, a prophylactic treatment with DAREN<sup>®</sup> is effective in treating Japanese cedar pollinosis.