著者

宇田 明史 寺田 勝英

出版者

一般社団法人日本PDA製薬学会

雑誌

日本PDA学術誌 GMPとバリデーション (ISSN:13444891)

巻号頁・発行日

vol.8, no.2, pp.94-105, 2006 (Released:2008-02-01)

著者

寺田 勝英

出版者

東京大学

巻号頁・発行日

1983

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博士論文

著者

仲井 由宣 山本 恵司 寺田 勝英 内田 武 清水 昶幸 西垣 貞男

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.30, no.7, pp.2629-2632, 1982-07-25 (Released:2008-03-31)

参考文献数

5

被引用文献数

9 14

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The crystal structure of ftorafur, C8H9FN2O3, has been determined by single-crystal X-ray diffraction techniques. The crystal is triclinic, space group P1 ; its unit-cell dimensions are a=8.994 (8), b=16.612 (9), c=5.981 (5) Å, α=86.40 (6), β=94.06 (15), γ=80.29 (8)°, Z=4. The structure was solved by the direct method and the final R value was 0.056.

著者

内田 武 米持 悦生 小口 敏夫 寺田 勝英 山本 恵司 仲井 由宣

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.41, no.9, pp.1632-1635, 1993-09-15 (Released:2008-03-31)

参考文献数

15

被引用文献数

13 20

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Four crystalline forms of tegafur were prepared by recrystallization from different solvents (α-, β-, δ-forms) and by heating (γ-form). They have been characterized using powder X-ray diffraction, thermal analysis, microscopy, density measurements and infrared spectroscopy. From differential scanning calorimetry measurements, it was confirmed that the γ- and δ-forms melted at 175°C and 165°C, whereas the α- and β-forms transformed into the γ-form at about 162°C and 120°C, respectively. The infrared absorption spectral differences observed between the α- and β-forms were discussed in relation to their intermolecular hydrogen bonding systems. It was also found that the difference in crystal forms significantly altered the dissolution rate of tegafur.