著者

名取 伸行 花輪 和己 鈴木 正彦 花輪 剛久 小口 敏夫

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.34, no.3, pp.289-296, 2008 (Released:2009-09-04)

参考文献数

6

被引用文献数

8 3

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A questionnaire survey of inpatients of widely varying ages was conducted to investigate the ease of taking internal medicines and desired dosage forms.A similar questionnaire survey of nurses and pharmacists working in a university hospital was also conducted to compare awareness of dosage forms by profession.The results of this survey clearly demonstrated the difference in awareness of patient preference regarding internal medicines among pediatric nurses,nurses working at other hospital wards,and pharmacists.This discrepancy seemed to reflect the difference in awareness of different health care workers concerning impairment of deglutition capability with aging.Awareness of patients' desired dosage forms also varied between pharmacists and nurses,which could be due to the difference in knowledge of pharmaceutics between these 2 professions.Based on the results of this study,it was felt that pharmacists should provide medication instruction to individual patients and provide pharmaceutical information to nurses,and that information sharing is important to ensuring that proper pharmaceutical care is conducted in the hospital.

著者

堤 きく江 土屋 千佳子 花輪 和己 鈴木 正彦 花輪 剛久 小口 敏夫

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.128, no.6, pp.965-970, 2008-06-01 (Released:2008-06-01)

参考文献数

18

被引用文献数

1 1

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Beraprost sodium (BPS) is often used for pediatric patients with pulmonary hypertension. The purpose of this study was to determine the expiration date of the powdered medicine prepared by grinding tablets. In the present study, the hygroscopicity and stability of the beraprost tablet (DORNER® tablet), ground Dorner tablet and powder formulation (Doener powder) consisting of the ground DORNER® tablet and lactose (EFC® lactose) were investigated after storage at various relative humidities (RHs) and light exposures. While the DORNER® tablets and ground DORNER® tablets were found to adsorb significant amounts of water vapor at an RHs of greater than 51.0%, Dorner powder scarcely adsorbed water. The stability of BPS in the Dorner powder decreased after storage under 3000 lux for 90 days. From these results, the expiration date and storage conditions of Dorner powder were determined to “90 days without exposure to light.” We also investigated the stability of BPS in solutions of various pH values on the assumption that Dorner powder may be given to pediatric patients after dissolving in soft drinks. Because BPS degraded significantly below pH 2, pharmacists should alert patients not to take Dorner powder with acidic soft drinks.

著者

小口 敏夫

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.44, no.4, pp.315-320, 2008-04-01 (Released:2018-08-26)

参考文献数

6

著者

小口 敏夫

出版者

千葉大学

巻号頁・発行日

1990

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学位:千大院薬博乙第79号

著者

内田 武 米持 悦生 小口 敏夫 寺田 勝英 山本 恵司 仲井 由宣

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.41, no.9, pp.1632-1635, 1993-09-15 (Released:2008-03-31)

参考文献数

15

被引用文献数

13 20

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Four crystalline forms of tegafur were prepared by recrystallization from different solvents (α-, β-, δ-forms) and by heating (γ-form). They have been characterized using powder X-ray diffraction, thermal analysis, microscopy, density measurements and infrared spectroscopy. From differential scanning calorimetry measurements, it was confirmed that the γ- and δ-forms melted at 175°C and 165°C, whereas the α- and β-forms transformed into the γ-form at about 162°C and 120°C, respectively. The infrared absorption spectral differences observed between the α- and β-forms were discussed in relation to their intermolecular hydrogen bonding systems. It was also found that the difference in crystal forms significantly altered the dissolution rate of tegafur.