著者

新甫 勇次郎 山崎 律 中島 嘉次郎 伊東 宏 竹下 尚 金城 順英 野原 稔弘

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.110, no.8, pp.604-611, 1990-08-25

被引用文献数

14

---

The present study was designed to examine the effects of methanolic extract (PE-ME), isoflavonoid fraction (PF-IF), triterpenoid saponin fraction (PF-SP) and N-acyl-N_1-glucosyl-tryptophan (PF-P) isolated from puerariae flos on alcohol-induced unusual metabolism (as for glucose (BG), triglyceride (TG), and urea nitrogen (BUN) level in blood) and experimental liver injury (model : CCl_4-and high fatty food induced) in mice. These alcohol-induced increasing responses were inhibited by the extracted and refined substances from puerariae flos. In short, PF-ME (4500 mg/kg) and PF-P (400 mg/kg) inhibited an increase in BG level induced by alcohol, whereas PF-IF (1000 mg/kg) and PF-SP (1000 mg/kg) did not. Similary, PF-ME and PF-SP inhibited an increase in TG induced by alcohol, whereas PF-IF did not. In addition, PF-IF and PF-SP inhibited increasing BUN level. Still more, PF-IF and PF-SP significantly inhibited an increase in gulutamate oxalacetate transaminase or gulutamate pyruvate transaminase level induced by high-fatty food and CCl_4 in control animals. Especially PF-IF (250 mg/kg) administration showed a remarkable effect (inhibition : 76.3%) in control animals. These results suggested that puerariae flos or its combination drugs may be a useful drug as a traditional medicinal system for counteraction to drinking.

著者

新甫 勇次郎 山崎 律 中島 嘉次郎 伊東 宏 竹下 尚 金城 順英 野原 稔弘

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.109, no.6, pp.424-431, 1989-06-25

被引用文献数

12

---

In the general rule, Puerariae Flos or it's combination drugs are used in traditional medicinal system for counteraction to drinking among Japanese and Chinese therapy. One of such drugs is Kakkakaiseito. Here we report the results of investigation on some pharmacological actions including alcoholic metabolism. The experiments were carried out to confirm its actual effect on alcohol, acetaldehyde and ketone body metabolism in the blood and the alteration of behaviour pattern of mice. Drugs used in this study were methanolic extract (PF-ME), isoflavonoid fraction (PF-IF) and triterpenoid saponin fraction (PF-SP) isolated from Puerariae Flos. Each drug was orally administrated to mice. These results were shown as follows : the concentrations of blood alcohol and acetaldehyde decreased more after the treatment with PF-IF (800 mg/kg) than those of the control group. This fact was evidenced remarkable effects with area under the blood concentration-time curve, mean residence time, and variance residence time and values on the moment analysis. However, a reduction effect was not recognized by the treatment with PF-SP (1000 mg/kg). Moreover, PF-ME and PF-IF suppressed the increment of spontaneous movement induced by alcohol administration, whereas PF-SP did not prevent the decrease in the increment caused by alcohol administration. These results support the basis that Puerariae Flos or its combination drugs is used in a traditional medicinal system for counteraction to drinking. However, further investigation is necessary.

著者

山崎 律子 本多 泰揮 原田 潮 鈴木 裕二 大塚 吉則

出版者

一般社団法人 日本温泉気候物理医学会

雑誌

日本温泉気候物理医学会雑誌 (ISSN:00290343)

巻号頁・発行日

vol.70, no.3, pp.165-171, 2007 (Released:2010-04-30)

参考文献数

21

---

PurposeHalf body bathing is popular among young women as well as elderly people. As a matter of fact, it is reported that half body bathing has a smaller burden than whole-body bathing from the point of physical influence. To clarify the relation between bathing habitude and health maintenance, that is, as an approach to general understanding the physiological effects by repeating bathing stimuli, the physiological changes by continuing half body bathing were studied.MethodsHalf body bathing was repeated for 4 weeks in healthy female subjects (N=10, age: 30.1±4.8, height: 160.4±6.1cm, weight: 55.6±7.0kg, body mass index: 20.9±1.6kg/m2, mean±SD).Bathing was performed for 30 minutes and 3times a week, with a level of epigastrium without immersing arms. Changes of blood flow and energy expenditure were measured during bathing at 0W and 4W.Results and DiscussionBy continuing bathing, blood flow increased more rapidly and higher during bathing, in addition, resting energy expenditure increased by 200kcal/day with a significant difference.From these findings, it is assumed that repeated half-body bathing enhances the increase of blood flow through repeating thermal stimuli, which leads to elevated basal metabolism.

著者

山崎 律子 本多 泰揮 原田 潮 鈴木 裕二 大塚 吉則

出版者

日本温泉気候物理医学会

雑誌

日本温泉気候物理医学会雑誌 (ISSN:00290343)

巻号頁・発行日

vol.70, no.3, pp.165-171, 2007-05

---

Purpose: Half-body bathing is popular among young women as well as elderly people. As a matter of fact, it is reported that half-body bathing has a smaller burden than whole-body bathing from the point of physical influence. To clarify the relation between bathing habitude and health maintenance, that is, as an approach to general understanding the physiological effects by repeating bathing stimuli, the physiological changes by continuing half-body bathing were studied. Methods: Half-body bathing was repeated for 4 weeks in healthy female subjects (N=10, age:30.1±4.8, height:160.4±6.1cm, weight:55.6±7.0kg, body mass index:20.9±1.6kg/m2, mean±SD). Bathing was performed for 30 minutes and 3times a week, with a level of epigastrium without immersing arms. Changes of blood flow and energy expenditure were measured during bathing at 0W and 4W. Results and Discussion: By continuing bathing, blood flow increased more rapidly and higher during bathing, in addition, resting energy expenditure increased by 200 kcal/day with a significant difference. From these findings, it is assumed that repeated half-body bathing enhances the increase of blood flow through repeating thermal stimuli, which leads to elevated basal metabolism.

著者

新甫 勇次郎 山崎 律 中島 嘉次郎 伊東 宏 竹下 尚 金城 順英 野原 稔弘

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.110, no.8, pp.604-611, 1990-08-25 (Released:2008-05-30)

参考文献数

33

被引用文献数

8 19

---

The present study was designed to examine the effects of methanolic extract (PE-ME), isoflavonoid fraction (PF-IF), triterpenoid saponin fraction (PF-SP) and N-acyl-N1-glucosyl-tryptophan (PF-P) isolated from puerariae flos on alcohol-induced unusual metabolism (as for glucose (BG), triglyceride (TG), and urea nitrogen (BUN) level in blood) and experimental liver injury (model : CCl4-and high fatty food induced) in mice. These alcohol-induced increasing responses were inhibited by the extracted and refined substances from puerariae flos. In short, PF-ME (4500 mg/kg) and PF-P (400 mg/kg) inhibited an increase in BG level induced by alcohol, whereas PF-IF (1000 mg/kg) and PF-SP (1000 mg/kg) did not. Similary, PF-ME and PF-SP inhibited an increase in TG induced by alcohol, whereas PF-IF did not. In addition, PF-IF and PF-SP inhibited increasing BUN level. Still more, PF-IF and PF-SP significantly inhibited an increase in gulutamate oxalacetate transaminase or gulutamate pyruvate transaminase level induced by high-fatty food and CCl4 in control animals. Especially PF-IF (250 mg/kg) administration showed a remarkable effect (inhibition : 76.3%) in control animals. These results suggested that puerariae flos or its combination drugs may be a useful drug as a traditional medicinal system for counteraction to drinking.

著者

新甫 勇次郎 山崎 律 中島 嘉次郎 伊東 宏 竹下 尚 金城 順英 野原 稔弘

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.109, no.6, pp.424-431, 1989-06-25 (Released:2008-05-30)

参考文献数

26

被引用文献数

7 31

---

In the general rule, Puerariae Flos or it's combination drugs are used in traditional medicinal system for counteraction to drinking among Japanese and Chinese therapy. One of such drugs is Kakkakaiseito. Here we report the results of investigation on some pharmacological actions including alcoholic metabolism. The experiments were carried out to confirm its actual effect on alcohol, acetaldehyde and ketone body metabolism in the blood and the alteration of behaviour pattern of mice. Drugs used in this study were methanolic extract (PF-ME), isoflavonoid fraction (PF-IF) and triterpenoid saponin fraction (PF-SP) isolated from Puerariae Flos. Each drug was orally administrated to mice. These results were shown as follows : the concentrations of blood alcohol and acetaldehyde decreased more after the treatment with PF-IF (800 mg/kg) than those of the control group. This fact was evidenced remarkable effects with area under the blood concentration-time curve, mean residence time, and variance residence time and values on the moment analysis. However, a reduction effect was not recognized by the treatment with PF-SP (1000 mg/kg). Moreover, PF-ME and PF-IF suppressed the increment of spontaneous movement induced by alcohol administration, whereas PF-SP did not prevent the decrease in the increment caused by alcohol administration. These results support the basis that Puerariae Flos or its combination drugs is used in a traditional medicinal system for counteraction to drinking. However, further investigation is necessary.

著者

新甫 勇次郎 山崎 律 石渡 宏衛 中島 嘉次郎 伊東 宏

出版者

和漢医薬学会

雑誌

和漢医薬学会大会要旨集

巻号頁・発行日

vol.5, 1988-08-06