著者

戸山 恭平 平島 昭雄 竹下 尚紀 西嶋 靖治

出版者

日本法科学技術学会

雑誌

日本法科学技術学会誌 (ISSN:18801323)

巻号頁・発行日

vol.18, no.1, pp.23-33, 2013 (Released:2013-02-20)

参考文献数

15

被引用文献数

1

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In order to estimate type and trajectory of the fired bullet from the analysis of the ricochet mark, we carried out the gunfire test against the inclined target. 1.2 mm thin steel plates were used as intermediate targets in this study. The following are types of cartridges which were used: 25 AUTO., 32 AUTO., 7.62 mm Tokarev, 380 AUTO., 38 SPL. (FMC), 38 SPL. (LRN), 9 mm Luger and 45 AUTO.. The target was put in a wooden frame. The angle of incidence was changed by rotating the wooden frame.   We could classify the deformation morphology on the thin steel plate into 4 patterns: Ricochet mark without the crack (Type 1), Ricochet mark with the small crack (Type 2), Ricochet mark with the large crack (Type 3), Penetration (Type 4). Metal from the bullet surface was left on the surface of the target. It was thought that the crack in the edge of the ricochet mark (Type 2 or 3) was caused by the friction arising from the rifling rotation of the fired bullet. The length of the ricochet mark in the longitudinal direction L increases with increase of the kinetic energy of the bullet E. The value of L was relative to the kinetic energy resolved into the horizontal component of the velocity Ecos2θi (θi: the angle of incidence). Except for 380 AUTO. and 38 SPL., the value of L was almost independent of E and Ecos2θi respectively. The ratio of the angle of ricochet θr to the angle of incidence θi was around 1 to 2. Therefore, caliber and type of a fired bullet and the trajectory can be determined from the analysis of the ricochet mark and the contour when the bullet is fired into a 1.2 mm thin steel plate.

著者

新甫 勇次郎 山崎 律 中島 嘉次郎 伊東 宏 竹下 尚 金城 順英 野原 稔弘

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.110, no.8, pp.604-611, 1990-08-25

被引用文献数

14

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The present study was designed to examine the effects of methanolic extract (PE-ME), isoflavonoid fraction (PF-IF), triterpenoid saponin fraction (PF-SP) and N-acyl-N_1-glucosyl-tryptophan (PF-P) isolated from puerariae flos on alcohol-induced unusual metabolism (as for glucose (BG), triglyceride (TG), and urea nitrogen (BUN) level in blood) and experimental liver injury (model : CCl_4-and high fatty food induced) in mice. These alcohol-induced increasing responses were inhibited by the extracted and refined substances from puerariae flos. In short, PF-ME (4500 mg/kg) and PF-P (400 mg/kg) inhibited an increase in BG level induced by alcohol, whereas PF-IF (1000 mg/kg) and PF-SP (1000 mg/kg) did not. Similary, PF-ME and PF-SP inhibited an increase in TG induced by alcohol, whereas PF-IF did not. In addition, PF-IF and PF-SP inhibited increasing BUN level. Still more, PF-IF and PF-SP significantly inhibited an increase in gulutamate oxalacetate transaminase or gulutamate pyruvate transaminase level induced by high-fatty food and CCl_4 in control animals. Especially PF-IF (250 mg/kg) administration showed a remarkable effect (inhibition : 76.3%) in control animals. These results suggested that puerariae flos or its combination drugs may be a useful drug as a traditional medicinal system for counteraction to drinking.

著者

新甫 勇次郎 山崎 律 中島 嘉次郎 伊東 宏 竹下 尚 金城 順英 野原 稔弘

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.109, no.6, pp.424-431, 1989-06-25

被引用文献数

12

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In the general rule, Puerariae Flos or it's combination drugs are used in traditional medicinal system for counteraction to drinking among Japanese and Chinese therapy. One of such drugs is Kakkakaiseito. Here we report the results of investigation on some pharmacological actions including alcoholic metabolism. The experiments were carried out to confirm its actual effect on alcohol, acetaldehyde and ketone body metabolism in the blood and the alteration of behaviour pattern of mice. Drugs used in this study were methanolic extract (PF-ME), isoflavonoid fraction (PF-IF) and triterpenoid saponin fraction (PF-SP) isolated from Puerariae Flos. Each drug was orally administrated to mice. These results were shown as follows : the concentrations of blood alcohol and acetaldehyde decreased more after the treatment with PF-IF (800 mg/kg) than those of the control group. This fact was evidenced remarkable effects with area under the blood concentration-time curve, mean residence time, and variance residence time and values on the moment analysis. However, a reduction effect was not recognized by the treatment with PF-SP (1000 mg/kg). Moreover, PF-ME and PF-IF suppressed the increment of spontaneous movement induced by alcohol administration, whereas PF-SP did not prevent the decrease in the increment caused by alcohol administration. These results support the basis that Puerariae Flos or its combination drugs is used in a traditional medicinal system for counteraction to drinking. However, further investigation is necessary.

著者

緒方 克守 吉田 遼司 米田 雅一 竹下 尚志 中山 秀樹 篠原 正徳

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.65, no.11, pp.719-725, 2019-11-20 (Released:2020-01-20)

参考文献数

22

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Traumatic carotid-cavernous sinus fistula (t-CCF) is an arteriovenous fistula formed by the tearing of the internal carotid artery running in the cavernous sinus, accompanied by head/maxillofacial injuries. Patients with this disease rarely show spontaneous closure and often require urgent endovascular treatment. We report a case of t-CCF that developed following jaw and zygoma fractures and was successfully treated by manual carotid compression. A 35-year-old man was referred to our hospital to undergo treatment for multiple maxillofacial fractures. On the first day after injury, open reduction and internal fixation of the mandible were conducted with the patient under general anesthesia. On the fifth day after injury, diplopia of the left eye suddenly appeared. On the seventh day after injury, left exophthalmos/edema of the left upper eyelid/left abducens nerve palsy/bilateral ptosis, and hyperemia of the bulbar conjunctiva appeared. On the 15th day after injury, cerebral angiography revealed a definitive diagnosis of t-CCF. Supervised manual carotid compression during the waiting period before endovascular treatment led to improvement in various symptoms from the 19th day after injury. Cerebral angiography, which was performed again for endovascular treatment, revealed that arteriovenous fistula resolved spontaneously. Therefore, treatment was discontinued, and the patient was followed up with a conservative approach. By 9 months after injury, all symptoms, including left oculomotor nerve palsy had disappeared. There was no evidence of recurrence 10 years after injury.

著者

新甫 勇次郎 山崎 律 中島 嘉次郎 伊東 宏 竹下 尚 金城 順英 野原 稔弘

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.110, no.8, pp.604-611, 1990-08-25 (Released:2008-05-30)

参考文献数

33

被引用文献数

8 19

---

The present study was designed to examine the effects of methanolic extract (PE-ME), isoflavonoid fraction (PF-IF), triterpenoid saponin fraction (PF-SP) and N-acyl-N1-glucosyl-tryptophan (PF-P) isolated from puerariae flos on alcohol-induced unusual metabolism (as for glucose (BG), triglyceride (TG), and urea nitrogen (BUN) level in blood) and experimental liver injury (model : CCl4-and high fatty food induced) in mice. These alcohol-induced increasing responses were inhibited by the extracted and refined substances from puerariae flos. In short, PF-ME (4500 mg/kg) and PF-P (400 mg/kg) inhibited an increase in BG level induced by alcohol, whereas PF-IF (1000 mg/kg) and PF-SP (1000 mg/kg) did not. Similary, PF-ME and PF-SP inhibited an increase in TG induced by alcohol, whereas PF-IF did not. In addition, PF-IF and PF-SP inhibited increasing BUN level. Still more, PF-IF and PF-SP significantly inhibited an increase in gulutamate oxalacetate transaminase or gulutamate pyruvate transaminase level induced by high-fatty food and CCl4 in control animals. Especially PF-IF (250 mg/kg) administration showed a remarkable effect (inhibition : 76.3%) in control animals. These results suggested that puerariae flos or its combination drugs may be a useful drug as a traditional medicinal system for counteraction to drinking.

著者

新甫 勇次郎 山崎 律 中島 嘉次郎 伊東 宏 竹下 尚 金城 順英 野原 稔弘

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.109, no.6, pp.424-431, 1989-06-25 (Released:2008-05-30)

参考文献数

26

被引用文献数

7 31

---

In the general rule, Puerariae Flos or it's combination drugs are used in traditional medicinal system for counteraction to drinking among Japanese and Chinese therapy. One of such drugs is Kakkakaiseito. Here we report the results of investigation on some pharmacological actions including alcoholic metabolism. The experiments were carried out to confirm its actual effect on alcohol, acetaldehyde and ketone body metabolism in the blood and the alteration of behaviour pattern of mice. Drugs used in this study were methanolic extract (PF-ME), isoflavonoid fraction (PF-IF) and triterpenoid saponin fraction (PF-SP) isolated from Puerariae Flos. Each drug was orally administrated to mice. These results were shown as follows : the concentrations of blood alcohol and acetaldehyde decreased more after the treatment with PF-IF (800 mg/kg) than those of the control group. This fact was evidenced remarkable effects with area under the blood concentration-time curve, mean residence time, and variance residence time and values on the moment analysis. However, a reduction effect was not recognized by the treatment with PF-SP (1000 mg/kg). Moreover, PF-ME and PF-IF suppressed the increment of spontaneous movement induced by alcohol administration, whereas PF-SP did not prevent the decrease in the increment caused by alcohol administration. These results support the basis that Puerariae Flos or its combination drugs is used in a traditional medicinal system for counteraction to drinking. However, further investigation is necessary.