2 0 0 0 OA 運動負荷時における人工心臓の制御方法について
- 著者
- 三宅 仁 藤正 巌 井街 宏 西坂 剛 大道 久 岩井 矩成 河野 明正 渥美 和彦
- 出版者
- 一般社団法人 日本人工臓器学会
- 雑誌
- 人工臓器 (ISSN:03000818)
- 巻号頁・発行日
- vol.7, no.1, pp.145-148, 1978-01-15 (Released:2011-10-07)
- 参考文献数
- 4
According to our total artificial heart experiment, the long survival can be achieved by maintainig of cardiac output in normal rate, which is 80 to 100ml/kg.When an experimental animal is made exercise, its cardiac output should be increase. The amount of increased cardiac output is seemed to relate venous pressure, peripheral resistance or partial O2 pressure of blood. The relation between load of exercise and such physiological data, as CVP, TPR and O2 consumption, were analysed quantitatively in this report.The results were; 1) By CVP, the cardiac output of artificial goat during exercise could not be determined. 2) TPR has some relation to the cardiac output but we need more precise study. 3) O2 consumtion is seem to be most useful information to control total artificial heart.
1 0 0 0 OA 人工心臓の拍出量制御と血液循環動態
- 著者
- 井街 宏 藤正 巌 大道 久 真野 勇 西坂 剛 岩井 矩成 渥美 和彦
- 出版者
- 一般社団法人 日本人工臓器学会
- 雑誌
- 人工臓器 (ISSN:03000818)
- 巻号頁・発行日
- vol.5, no.6, pp.321-327, 1976-12-15 (Released:2011-10-07)
- 参考文献数
- 16
The rapid decrease in hematocrit (Ht) and total protein (Tp), gradual increase in central venous pressure, and peripheral circulatory insufficiency such as impossibility of standing up, poor appetite, anuria or oliguria and constipation or mucous feces were the most serious physiological problems in recent total artificial heart (AH) animal experiments. For these phenomena, a phsiological hypothesis was presented by authors under the consideration of that too much cardiac output for animal might induce such phenomena.As the results of animal experiments with goat, the following finidings were obtained.(1) High cardiac output of AH causes a marked decrease in Ht and Tp, as well as peripheral circulatory insufficiency.(2) By maintaining the cardiac output within the range of 80 to 100ml/Kg/min. during the experiments, maximum and average survival days of the goats replaced totally with AH were markedly prolonged, from 10 days to 54 days and from 4.5 days to 30.5 days, respectively. And the surviving condition of these goats were almost normal physiologically and pathophysiologically.(3) As conclusion, it became obvious that the cardiac output was one of the most important physiological parameter for control of the circulatory system.