著者
三宅 仁 藤正 巌 井街 宏 西坂 剛 大道 久 岩井 矩成 河野 明正 渥美 和彦
出版者
一般社団法人 日本人工臓器学会
雑誌
人工臓器 (ISSN:03000818)
巻号頁・発行日
vol.7, no.1, pp.145-148, 1978-01-15 (Released:2011-10-07)
参考文献数
4

According to our total artificial heart experiment, the long survival can be achieved by maintainig of cardiac output in normal rate, which is 80 to 100ml/kg.When an experimental animal is made exercise, its cardiac output should be increase. The amount of increased cardiac output is seemed to relate venous pressure, peripheral resistance or partial O2 pressure of blood. The relation between load of exercise and such physiological data, as CVP, TPR and O2 consumption, were analysed quantitatively in this report.The results were; 1) By CVP, the cardiac output of artificial goat during exercise could not be determined. 2) TPR has some relation to the cardiac output but we need more precise study. 3) O2 consumtion is seem to be most useful information to control total artificial heart.
著者
青山 慎 山岸 隼 三宅 仁
出版者
公益社団法人 日本生体医工学会
雑誌
生体医工学 (ISSN:1347443X)
巻号頁・発行日
vol.53, no.Supplement, pp.S393-S395, 2015 (Released:2016-06-18)

The stress is classified roughly into the distress and the eustress. The method for distress reduction is to receive counseling. However more convenient stress evaluation system is needed. We focused on onomatopoeias. Relevance of them and stress was investigated. The first purpose of this study was to develop of simple evaluation system using onomatopoeias. The second was to evaluate the system and usefulness of onomatopoeias. Ten male subjects were participated in the experiment using the system for two weeks. After that, they answered the system evaluation test of 34 items in 5-stages. As the result, the average was 3.94. Therefore, the system evaluated as a high rate. However, the average of one evaluation item, "This system leads to distress reduction", was 2.8. This means that the system could not reduce subjects' distress. Thus, the system needs a more clear feedback that those users are in the distress state.
著者
中瀬 裕之 田村 健太郎 玉置 亮 竹島 靖浩 乾 登史孝 三宅 仁 堀内 薫 榊 寿右
出版者
日本静脈学会
雑誌
静脈学 (ISSN:09157395)
巻号頁・発行日
vol.18, no.3, pp.157-161, 2007 (Released:2022-07-09)
参考文献数
20

当科における術後脳静脈梗塞の症例から,術後脳静脈梗塞の臨床的特徴を検討し,合併症(術後静脈梗塞)を回避するために注意すべきことについて述べる.脳外科手術中の脳静脈損傷により術後静脈梗塞を起こした自験例8症例(全手術中の0.3%),男性3例,女性5例(平均58.1歳)を対象とした.二次性静脈血栓の進展により緩徐に症状が発現してくる群(n=5)と急激に脳静脈灌流障害を起こしてくる群(n=3)の2群に分類できた.症状の発現が旱いものほど重篤な症状がみられた.外科的療法を要したものが2例,保存的に対処できたものが6例である.予後は良好が6例,軽度障害を残したものが2例であった.術後脳静脈梗塞を少なくするためには,(1)術前に静脈解剖を考慮し,重要な静脈を避けた手術アプローチの選択,(2)静脈を損傷しない手術法の工夫, (3)脳静脈損傷時の対処や術後管理など,できるかぎり静脈を温存し合併症を早期に予測し予防する努力が必要である.
著者
三宅 仁 宮本 義行 瀬 和頼 藤本 輝雄
出版者
一般社団法人 日本人工臓器学会
雑誌
人工臓器 (ISSN:03000818)
巻号頁・発行日
vol.13, no.3, pp.1243-1246, 1984-06-15 (Released:2011-10-07)
参考文献数
7
被引用文献数
1

抗血栓性材料の分子設計に当り、表面荷電の影響が注目されているが、プラスとマイナスのモザイク状態を保つような材料の合成が困難であるため十分な研究はなされていない。著者らは新しく開発されたマルチブロック共重合体を用い、無荷電、プラス荷電、マイナス荷電、プラス・マイナス・無荷電のモザイク荷電をそれぞれもつ材料を合成し、血小板との相互作用を検討した。その結果以下の事実が明らかになった。未処理(無荷電)およびプラス荷電材料においては血小板が多数粘着し、マイナスおよびモザイク荷電材料は比較的良好な血小板粘着抑制効果を示した。この事実は、全血凝固過程による評価方法の結果と一致しなかった。モザイク荷電材料のみが血小板粘着抑制および全血凝固過程の両者ともに比較的良好な結果を示した。これらの事実は、モザイク荷電材料が理想的な抗血栓性材料となりうることを示唆しているものと考えられる。
著者
沖浦 達幸 西村 浩治 西向 弘明 三宅 仁
雑誌
DNA多型 = DNA polymorphism
巻号頁・発行日
vol.13, pp.274-277, 2005-05-30
参考文献数
5
被引用文献数
1
著者
小島 輝明 高本 俊一 森岡 賢次 山本 晋平 綿貫 雅也 長谷川 光彦 三宅 仁 塩野谷 明
出版者
Society of Biomechanisms
雑誌
バイオメカニズム (ISSN:13487116)
巻号頁・発行日
vol.16, pp.231-241, 2002

It is effective to determine running pace in advance, based on individual ability, in order to demonstrate the highest performance in long-distance running. The evaluation indices for a long-distance runner are maximum oxygen uptake, lactate threshold (LT), and ventilatory threshold (VT). These, however, are mostly used stastistically, so results may differ from real ability in a personal equation.<BR>The purposes of this study were to construct an energy-metabolism model and to optimize the running pace of long-distance running using a genetic algorithm (GA). The energy-metabolism model constructed in the study was composed of an anaerobic energy feeder structure, an aerobic energy feeder structure, and the section to be run. These elements were expressed as differential equations and restricted inequality formulas. The running speed for each subject, calculated from the best time for 300 meters, the amount of oxygen uptake, and running speed at the VT in each subject were used as parameters for the energy-metabolism model.<BR>VT was measured by a gradually increasing speed exercise using a treadmill because it was difficult to measure during field running. There are many differences between treadmill running and field running, however. In this study, the subject ran continuously on a treadmill with traction to his back using a rubber tube. The running speed for treadmill running was adjusted to that in field running based on heart rate.<BR>The energy-metabolism model had two controlled variables, and running speed could be controlled by these variables. We tried to optimize the energy-metabolism model by determining the two controlled variables using a GA. The spurt start point was also determined during optimization. The GA determined the spurt start point based on the energy-metabolism model.<BR>The running speed in 5000-meter races was optimized as follows: (1) speed ascends immediately after the start of the race, and then descends by a constant degree; (2) speed ascends again at 1000 to 1400 meters before the goal; and (3) almost 1 minute later, running goes to maximum speed then descends again by a constant degree all the way to the goal. This optimization result corresponded closely to the actual racing of the subject, who trained for improved ability in long-distance running.
著者
小島 輝明 高本 後一 森岡 賢次 山本 晋平 綿貫 雅也 長谷川 光彦 三宅 仁 塩野谷 明
出版者
バイオメカニズム学会
雑誌
バイオメカニズム
巻号頁・発行日
vol.16, pp.231-241, 2002-06-25

It is effective to determine running pace in advance, based on individual ability, in order to demonstrate the highest performance in long-distance running. The evaluation indices for a long-distance runner are maximum oxygen uptake, lactate threshold (LT), and ventilatory threshold (VT). These, however, are mostly used stastistically, so results may differ from real ability in a personal equation. The purposes of this study were to construct an energy-metabolism model and to optimize the running pace of long-distance running using a genetic algorithm (GA). The energy-metabolism model constructed in the study was composed of an anaerobic energy feeder structure, an aerobic energy feeder structure, and the section to be run. These elements were expressed as differential equations and restricted inequality formulas. The running speed for each subject, calculated from the best time for 300 meters, the amount of oxygen uptake, and running speed at the VT in each subject were used as parameters for the energy-metabolism model. VT was measured by a gradually increasing speed exercise using a treadmill because it was difficult to measure during field running. There are many differences between treadmill running and field running, however. In this study, the subject ran continuously on a treadmill with traction to his back using a rubber tube. The running speed for treadmill running was adjusted to that in field running based on heart rate. The energy-metabolism model had two controlled variables, and running speed could be controlled by these variables. We tried to optimize the energy-metabolism model by determining the two controlled variables using a GA. The spurt start point was also determined during optimization. The GA determined the spurt start point based on the energy-metabolism model. The running speed in 5000-meter races was optimized as follows: (1) speed ascends immediately after the start of the race, and then descends by a constant degree; (2) speed ascends again at 1000 to 1400 meters before the goal; and (3) almost 1 minute later, running goes to maximum speed then descends again by a constant degree all the way to the goal. This optimization result corresponded closely to the actual racing of the subject, who trained for improved ability in long-distance running.