著者

髙橋 誠 高山 慎太郎 須賀 秀行 門村 将太 小島 雅和 岩尾 一生 武田 清孝 佐藤 秀紀 小林 道也 齊藤 浩司

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.140, no.1, pp.81-90, 2020-01-01 (Released:2020-01-01)

参考文献数

16

被引用文献数

3

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We previously reported the association of the estimated glomerular filtration rate (eGFRcreat) calculated from the serum creatinine level (S-Cr) measured using the Jaffe method with the GFR (eGFRcys) estimated from the serum cystatin C level (CysC). However, few studies have compared the eGFRcreat using the enzymatic method with the eGFRcys. It is unclear whether there are differences in the results of renal function assessment. The purpose of this study was to compare the eGFRcreat calculated from the S-Cr with the eGFRcys calculated from the CysC in patients in whom the S-Cr and CysC were simultaneously measured using the enzymatic method, examine the correlations of respective parameters, and clarify physiological factors involved in differences among the parameters. The subjects were 1334 patients treated in 5 institutions. The mean values and correlation coefficient were statistically analyzed using Student's t-test and Pearson's test, respectively. Influential factors between formulae were analyzed using multiple regression analysis. The mean eGFRcreat was 67.0 mL/min/1.73 m2, being significantly higher than the mean eGFRcys (63.2). Multiple regression analysis showed that factors influencing differences in the S-Cr and CysC included the sex, age, serum albumin, and blood urea nitrogen BUN/S-Cr. Furthermore, factors involved in the overestimation of the eGFRcreat in comparison with the eGFRcys included the serum albumin and BUN/S-Cr. The differences between the eGFRcreat calculated from the S-Cr and eGFRcys were less marked than when adopting the Jaffe method in our previous study. However, the eGFRcreat were higher than the eGFRcys in patients with malnutrition or dehydration.

著者

岩尾 一生 小林 道也 及川 孝司 中駄 優作 藤崎 博子 室谷 光治 伊藤 昭英 辻 昌宏 井出 肇 遠藤 泰 関川 彬 齊藤 浩司

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.34, no.2, pp.112-117, 2008 (Released:2009-09-04)

参考文献数

14

被引用文献数

4 1

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A questionnaire survey was conducted to investigate the use of health foods among outpatients with diabetes mellitus (DM) at the Health Sciences University of Hokkaido Hospital.Responses were obtained from 69.2% of the patients (180 out of 260).The proportions of patients who had used health foods previously or were using them at the time of the survey were 16.7 and 37.2%,respectively,indicating that more than half of the patients had experience of taking health foods and this was irrespective of sex and age.The most frequently consumed health foods were Aojiru (n=25)followed by Kurozu (n=24)and blueberry extract (n=17).Among the health foods taken,those that influence blood sugar considerably were guava leaves polyphenol (n=16),Gymnema sylvestre extract (n=1),Gymnema sylvestre tea (n=1),and Aloe Vera (n=1).One patient was taking a Chinese health food that contained glibenclamide.Many patients took health foods to keep healthy and as a nutritional supplement,and most of them had not consulted their doctors or pharmacists about the use of health foods.More than 70% of the patients targeted by this study had complications such as hypertension.Since there is a possibility of health foods aggravating DM and its complications and of interactions between them and drugs used to treat DM,doctors,pharmacists and other co-medical workers should provide patients with information on the ingredients of health foods as well the adverse effects that they could have.