1 0 0 0 OA 線虫を用いた次世代膵癌診断法の有効性についての検討
膵癌の予後は極めて不良であり、新規診断・治療法の開発が急務となっている。本研究では野生型線虫の嗅覚を応用したN-NOSE法を用いることで癌の匂いを科学的に検討し線虫が膵腫瘍発生を組織学的に確認された膵腫瘍自然発生モデルマウスの尿に対してもヒト同様の誘引行動を呈することを示した。線虫の行動をげっ歯類で再現できたことの重要性は、これまではヒトの臨床検体を用いていたため、サンプルの多様性も影響し、原因物質の同定までは至らなかった可能性も示唆されるが、このマウスモデルを利用することで、走行性を惹起する物質の同定が可能となることが期待され、N-NOSE法が膵癌の早期診断の一助になる可能性も示唆された。
- 著者
- 富丸 慶人 後藤 邦仁 小林 省吾 永野 浩昭 森 正樹 土岐 祐一郎 江口 英利 伊藤 壽記 野口 洋文 宮下 和幸 川本 弘一 岩上 佳史 秋田 裕史 野田 剛広
- 出版者
- 一般社団法人 日本移植学会
- 雑誌
- 移植 (ISSN:05787947)
- 巻号頁・発行日
- vol.54, no.4, pp.217-222, 2019
<p>Total pancreatectomy with islet autotransplantation is an ideal surgical procedure used to relieve chronic pain derived from the pancreatitis, while insulin-dependent diabetes is inevitably induced after the surgery. Islet autotransplantation combined with a total pancreatectomy can reduce the risk of severe diabetes by preserving available islet cells. We experienced a case with hereditary pancreatitis, which is a rare inherited condition characterized by recurrent acute pancreatitis and/or chronic pancreatitis. The case was that of a female in her thirties who was introduced to our hospital due to treatment-refractory abdominal pain derived from repeated pancreatitis even after surgical treatments. At the introduction, the pain was uncontrollable even by opioid use, and oral intake was impossible due to increase of the pain after the intake. She was genetically diagnosed with hereditary pancreatitis. For relieving the pancreatitis-derived pain, total remnant pancreatectomy with islet autotransplantation was planned. After the pancreatectomy, islet cells were extracted from the excised remnant pancreas, and injected into the portal vein for liver autotransplantation. The pain was completely relieved for her after the surgery, suggesting improvement of her quality-of-life. A glucose tolerance test and glucagon loading test performed one month after the surgery showed C-peptide secretion as the blood glucose rose. However, the serum c-peptide level and SUIT index had been gradually decreased after the surgery, and she is now treated with insulin. The case suggested that total pancreatectomy with islet autotransplantation is useful for improvement of the patient's quality of life by controlling the pain in cases with hereditary pancreatitis.</p>