著者
徳永 隆久 中田 裕子 田代 靖人 平山 匡男 日高 秀昌
出版者
財団法人 日本ビフィズス菌センター
雑誌
ビフィズス (ISSN:09142509)
巻号頁・発行日
vol.6, no.2, pp.143-150, 1993 (Released:2010-06-28)
参考文献数
16
被引用文献数
5

27名の健常者 (男21名, 女6名) を3群に分け, フラクトオリゴ糖 (FOS) 1g, 3g, 5g/日をそれぞれ2週間摂取させて腸内細菌叢および便通に及ぼす影響について調べた.その結果, いずれのFOS摂取水準においても, 便中のBifidobacteriumの菌数は有意に増加した (p<0.01またはp<0.05).また, 全試験期間中の被験者の便通状況を解析した結果, FOS摂取により排便回数の有意な増加と (p<0.05), 便の硬さが有意に軟らかくなる (p<0.01) ことが観察され, 便通の改善効果が認められた.
著者
斎藤 顕宜 森田 佳代 上野 慶一 八巻 芳夫 滝沢 登志雄 徳永 隆久 亀井 淳三
出版者
Japan Society for Bioscience, Biotechnology, and Agrochemistry
雑誌
日本農藝化學會誌 = Journal of the Agricultural Chemical Society of Japan (ISSN:00021407)
巻号頁・発行日
vol.77, no.12, pp.1242-1245, 2003-12-01
参考文献数
17

Rosemary, plantago, and tea tree oil have been customarily used for the treatment of the common cold, but the detailed mechanisms of these antitussive effects are not well known. Thus, the aim of this study was to assess the antitussive properties of these herbs using a capsaicin-induced cough model in guinea pigs. Rosemary (10, 30μL/kg, <i>p.o.</i>), plantago (10, 30mg/kg, <i>p.o.</i>), and tea tree oil (10, 30μL/kg, <i>p.o.</i>) produced dose-dependent and significant antitussive effects. Methysergide (a serotonin receptor antagonist), but not naloxone (a opioid receptor antagonist), antagonize the antitussive effects of plantago and tea tree oil. On the other hand, neither methysergid nor naloxone had a significant effect on the antitussive effect of rosemary. Furthermore, γ-terpinene, terpinene-4-ol, cineole, and α-pinene, main components of tea tree oil and rosemary, significantly inhibited the number of capsaicin-induced coughs in guinea pigs. These results suggest that the antitussive effects of plantago and tea tree oil may depend on central mechanisms (modulation of serotonergic systems). On the other hand, the antitussive effects of rosemary may depend on peripheral mechanisms. Furthermore, it is suggested that γ-terpinene, terpinene-4-ol, cineole, and α-pinene may play an important role in the antitussive effects of tea tree oil and rosemary.