著者

木須 伊織 阪埜 浩司 青木 大輔

出版者

一般社団法人 日本移植学会

雑誌

移植 (ISSN:05787947)

巻号頁・発行日

vol.57, no.1, pp.9-22, 2022 (Released:2022-05-19)

参考文献数

31

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A new medical technique called uterus transplantation has been considered as an option for raising children of women with uterine factor infertility. Clinical studies have already begun overseas, and 87 uterus transplantations have been performed so far, and 49 babies have been born. Uterus transplantation, like other assisted reproductive technology, involves many medical, ethical, and social challenges that must be carefully considered for clinical application. However, uterus transplantation is highly expected to bring the gospel to women with uterine factor infertility who were previously unable to raise children.

著者

木須 伊織

出版者

一般社団法人 日本臓器保存生物医学会

雑誌

Organ Biology (ISSN:13405152)

巻号頁・発行日

vol.25, no.1, pp.35-40, 2018 (Released:2018-03-14)

参考文献数

13

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Uterus transplantation (UTx) has become an alternative to gestational surrogacy and adoption for women with uterine factor infertility. Brännström et al. achieved the first human delivery after UTx in 2014 and to date a total of 8 babies have been born after UTx from living donors. This outcome attracted much attention worldwide and many countries have recently prepared for UTx. However, this procedure has many medical, ethical and social issues that require discussion prior to clinical application. Moreover, UTx is still in the experimental stage overseas and the safety and efficacy remain unclear despite several clinical applications. Despite the many issues to be resolved, this new organ transplantation technology will provide new hope for women with uterine factor infertility and further development of the technology is important for future reproductive and transplant medicine.

著者

木須 伊織

出版者

慶應義塾大学

雑誌

若手研究(A)

巻号頁・発行日

2017-04-01

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MHC(主要組織適合遺伝子複合体)統御カニクイザルを用いて子宮同種移植モデルを作製し、血液型一致のMHCミスマッチ間および半ハプロ一致間における移植子宮の生着を比較した。カニクイザルにおける子宮においては拒絶反応をきたしやすく、抗原性が高いことが示された。また、半ハプロ一致間におけるカニクイザルペア間における子宮移植後に妊娠出産に世界で初めて成功した。日本産科婦人科学会、日本移植学会に子宮移植に関する見解を求める要望書を提出し、日本医学会で子宮移植に関する検討委員会が設立され、国内での臨床応用の可能性について議論が行われている。