著者

村上 雅裕 中谷 真由美 安田 恵 天野 学

出版者

Japanese Society of Drug Informatics

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.18, no.3, pp.209-213, 2016 (Released:2017-02-14)

参考文献数

12

被引用文献数

1

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Objective: The squeezing force and one-drop weight, suggested to directly influence adherence, were measured in 6 eye drop products containing a switch OTC drug, ketotifen fumarate, to investigate useful information for product selection.Methods: The squeeze force, one drop weight, and pH were measured using a digital force gauge, analytical balance, and pH meter, respectively.  Information on additives contained in each product was collected from package inserts.  For the total number of drops, the number per 10 mL was calculated from the obtained value.Results: The maximum squeeze force was 14.8 N of Irice AG Guard, and the one drop weight (33.2 mg) of Raferusa®AL was the minimum.  The total number of drops per 10 mL was 215 in Sutto eyes Z, being the minimum.  The pH was in the range of 5.2-5.7.  On comparison of additives among the products, a cooling agent was contained in only 2 products.Discussion: Since the squeeze force was in the range of 5.3-14.8 N, it was less likely that the squeeze force reduces usability.  Since the one-drop weights of 2 products were more than 10 mg lower than the weights of the other products, the dose may be insufficient and the effect may not be attained.  The pH was within the acceptable range in all products.  Two products contain a cooling agent as an additive, and this has to be explained beforehand.  Information related to usability, actual feeling of the effect, and sense of the use of the products containing ketotifen fumarate was collected.

著者

村上 雅裕 池本 憲彦 戸屋 成未 朴 美姫 奥山 美結樹 畠山 和子 桂木 聡子 大野 雅子 比知屋 寛之 座間味 義人 室 親明 木村 健 倉田 なおみ 天野 学

出版者

日本社会薬学会

雑誌

社会薬学 (ISSN:09110585)

巻号頁・発行日

vol.35, no.1, pp.34-37, 2016-06-10 (Released:2016-07-06)

参考文献数

9

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To administer oral anticancer drugs safely, the simple suspension method has been introduced in many hospitals. Therefore, concerning drugs for which it is unclear whether or not this method is applicable, testing must be able to be conducted at any time. In this study, we investigated 20 oral anticancer drugs to expand information on the application of the simple suspension method. Disintegration/suspension and permeability tests were conducted, as described in the 3rd version of the Tube Administration Handbook for Oral Drugs. All products were disintegrated/suspended after 10 minutes. On permeability tests, there was no residue in any tube for tubal feeding. On the final evaluation, the products were regarded as suitable (grade 1). Bicalutamide tablets (80 mg, TCK and KN), which were analyzed in this study, were regarded as suitable (grade 1) on the final evaluation. On the other hand, the simple suspension method is not applicable for a brand-name drug, Casodex® tablets (80 mg). This may be related to the different additives. Furthermore, the results suggest that, even when the simple suspension method is not applicable for a brand-name drug, it may become applicable for generic drugs. This may provide a new merit for promoting the use of generic drugs.

著者

村上 雅裕 桂木 聡子 行廣 佳奈 大野 雅子 天野 学 森山 雅弘

出版者

一般社団法人日本医薬品情報学会

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.17, no.3, pp.133-139, 2015 (Released:2015-12-18)

参考文献数

7

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Objective: Along with the globalization of the Japanese economy, the number of international students in Japan has gradually increased.  Under these circumstances, international students to visit pharmacies for self-medication are expected to increase.  Thus, we carried out a questionnaire survey on international students conducting self-medication using non-prescription drugs, and examined its problem.Method: To clarify the status of self-medication using OTC drugs by students studying abroad, multiple-choice and free description-style questionnaire sheets written in Japanese or English were distributed to 30 international students based in Kobe City.  The sheets were independently completed by the students, excluding those who had difficulty in sufficiently comprehending the questions and required the researcher’s oral explanations for assistance.Result: While 90.0% of the respondents answered that they occasionally use non-prescription drugs in their own countries, only 60.0% answered that they had experience of purchasing the drugs in Japan.  When purchasing OTC drugs, 15.2% faced <difficulty in reading> instructions printed on their packages.  While 30.0% regarded <pharmacists’ advice> as important to purchase appropriate drugs in their home countries, only 23.3% sought such advice in Japan.Conclusion: These results revealed a tendency for international students to purchase OTC drugs following pharmacists’ advice less frequently in Japan than in their home countries despite their literacy difficulties.  In the future, we hope to examine issues such as possible active communication by pharmacists and the drugstore structure, so as to promote self-medication through purchasing drugs at Japanese pharmacies.  As a result, we hope to contribute to making Japanese pharmacies more foreign user-friendly in a real sense.

著者

村上 雅裕 安田 恵 新村 健 天野 学

出版者

日本社会薬学会

雑誌

社会薬学 (ISSN:09110585)

巻号頁・発行日

vol.39, no.2, pp.87-92, 2020-12-10 (Released:2020-12-30)

参考文献数

6

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In awareness-raising activities for medical cost reduction, many drug-related words, including loan words, are used. The use of loan words may reduce the effectiveness of activities to raise awareness among elderly people with difficulty understanding these words. We examined the recognition of drug-related words among the elderly aged 65 or over. The word “generic drugs” had the highest recognition rate, at 94.7%, and those for “general drugs” and “leftover medications” also exceeded 70%. In contrast, the recognition rates for loan words, such as “authorized generics” and “biosimilars”, were markedly low, at 1.5%. The results suggest that the recognition of some words is poor among nonprofessionals, even if they are commonly used by professionals. In activities to raise awareness of medical cost reduction among elderly people, it may be important to use simpler words, and provide more detailed explanations, such as showing actual products.

著者

村上 雅裕 中谷 真由美 太田 千裕 安田 恵 天野 学

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.43, no.10, pp.592-598, 2017-10-10 (Released:2018-10-10)

参考文献数

15

被引用文献数

1

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To provide appropriate information concerning ethical or Rx-OTC-switch drugs containing the same ingredients by pharmacists, it is necessary to understand the properties of both. In this study, pharmaceutical properties and economics were compared between ethical and Rx-OTC-switch anti-allergy ophthalmic solutions containing tranilast, pemirolast, or acitazanolast.Regarding 14 ethical and 3 Rx-OTC-switch products, the squeeze force, drop weight, pH, specific gravity, and total number of drops were measured. The usable period per bottle and daily cost were calculated from the total number of drops.The squeeze forces of the three drugs differed about 1.5-2 times among their products. Single-drop volumes calculated from the drop weights and specific gravities ranged from 30 to 46 μL for 0.5% tranilast ophthalmic solution, larger for the original drugs than for the Rx-OTC-switch and generic ones. The pH values of the ophthalmic solutions differed among the drugs, but not among their products. The usable periods of each bottle of the three drugs were longer for the Rx-OTC-switch drugs. However, the daily drug costs of 0.1% pemirolast ophthalmic solution were higher for the Rx-OTC-switch drug than for the original one, although those of 0.5% tranilast ophthalmic solution were lower.The present study demonstrated that the squeeze forces and drop volumes differed between the Rx-OTC-switch and ethical drugs and that the usable periods of each bottle and daily costs differed among the drugs. It is important for pharmacists to obtain information on the pharmaceutical properties and economics for in order to select products for individual patients.

著者

清水 忠 西村 奏咲 安田 恵 村上 雅裕 橋本 佳奈 大野 雅子 桂木 聡子 上田 昌宏 天野 学

出版者

日本薬学教育学会

雑誌

薬学教育 (ISSN:24324124)

巻号頁・発行日

vol.2, pp.2018-014, 2018 (Released:2018-08-24)

参考文献数

7

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薬学実務実習終了生を対象としたアンケート調査によれば,大半の学生は実習中に基礎薬学の知識を活用する機会は少なかったと感じていることが報告されている.その要因として,教員が基礎薬学は臨床現場でどのように役に立つかを具体的に説明できていないことが指摘されている.しかし,臨床現場での問題は基礎薬学が問題解決に有用となることもある.そのため,基礎系教員と臨床系教員が連携し基礎薬学の臨床現場での有用性を理解させ,それが可能であることを示すことが必要であると考えた.そこで,実務実習事前学習において有機化学を専門とする基礎系教員と実務家教員が連携した医薬品の配合変化に関する実習を実施し,終了後にアンケートを行った.この結果,受講生の90%以上が基礎薬学の内容が臨床の問題を解決するのに有用であることを意識できた.すなわち,基礎薬学が臨床現場でどのように役に立つかを意識させる実習を提供できたと考えられる.

著者

村上 雅裕 三浦 友里 桂木 聡子 大野 雅子 天野 学 森山 雅弘

出版者

Japanese Society of Drug Informatics

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.17, no.3, pp.140-144, 2015 (Released:2015-12-18)

参考文献数

5

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Objective: For pharmacists to select a suitable auxiliary device for eye drop administration for patients who have difficulty in applying eye drops, the pharmacists need to know the characteristics and level of difficulty of using each device.Methods: Thus, we compared the characteristics of New Rakuraku Tengan, Rakuraku Tengan III, and an eye-drop self-help device and also conducted a survey involving 40 healthy volunteers on each device’s accessibility and suitability for people with motor disabilities.Results: New Rakuraku Tengan received the highest score for “usage was able to easily understand” (70.0% of the respondents answered positively) and “suitability for poor-sighted people” (65.0%).  Rakuraku Tengan III received the highest score for the “effectiveness of photos and illustrations in the manual” (77.5%), but was evaluated to be difficult to use.  The eye-drop self-help device received the highest score for “suitability for people with difficulty raising their shoulders and arms” (75.0%).Results: Thus, we observed the need for pharmacists to have thorough knowledge of the products in order to recommend suitable auxiliary devices for eye drop administration for each patient.