著者

村上 雅裕 池本 憲彦 戸屋 成未 朴 美姫 奥山 美結樹 畠山 和子 桂木 聡子 大野 雅子 比知屋 寛之 座間味 義人 室 親明 木村 健 倉田 なおみ 天野 学

出版者

日本社会薬学会

雑誌

社会薬学 (ISSN:09110585)

巻号頁・発行日

vol.35, no.1, pp.34-37, 2016-06-10 (Released:2016-07-06)

参考文献数

9

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To administer oral anticancer drugs safely, the simple suspension method has been introduced in many hospitals. Therefore, concerning drugs for which it is unclear whether or not this method is applicable, testing must be able to be conducted at any time. In this study, we investigated 20 oral anticancer drugs to expand information on the application of the simple suspension method. Disintegration/suspension and permeability tests were conducted, as described in the 3rd version of the Tube Administration Handbook for Oral Drugs. All products were disintegrated/suspended after 10 minutes. On permeability tests, there was no residue in any tube for tubal feeding. On the final evaluation, the products were regarded as suitable (grade 1). Bicalutamide tablets (80 mg, TCK and KN), which were analyzed in this study, were regarded as suitable (grade 1) on the final evaluation. On the other hand, the simple suspension method is not applicable for a brand-name drug, Casodex® tablets (80 mg). This may be related to the different additives. Furthermore, the results suggest that, even when the simple suspension method is not applicable for a brand-name drug, it may become applicable for generic drugs. This may provide a new merit for promoting the use of generic drugs.

著者

村上 雅裕 桂木 聡子 行廣 佳奈 大野 雅子 天野 学 森山 雅弘

出版者

一般社団法人日本医薬品情報学会

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.17, no.3, pp.133-139, 2015 (Released:2015-12-18)

参考文献数

7

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Objective: Along with the globalization of the Japanese economy, the number of international students in Japan has gradually increased.  Under these circumstances, international students to visit pharmacies for self-medication are expected to increase.  Thus, we carried out a questionnaire survey on international students conducting self-medication using non-prescription drugs, and examined its problem.Method: To clarify the status of self-medication using OTC drugs by students studying abroad, multiple-choice and free description-style questionnaire sheets written in Japanese or English were distributed to 30 international students based in Kobe City.  The sheets were independently completed by the students, excluding those who had difficulty in sufficiently comprehending the questions and required the researcher’s oral explanations for assistance.Result: While 90.0% of the respondents answered that they occasionally use non-prescription drugs in their own countries, only 60.0% answered that they had experience of purchasing the drugs in Japan.  When purchasing OTC drugs, 15.2% faced <difficulty in reading> instructions printed on their packages.  While 30.0% regarded <pharmacists’ advice> as important to purchase appropriate drugs in their home countries, only 23.3% sought such advice in Japan.Conclusion: These results revealed a tendency for international students to purchase OTC drugs following pharmacists’ advice less frequently in Japan than in their home countries despite their literacy difficulties.  In the future, we hope to examine issues such as possible active communication by pharmacists and the drugstore structure, so as to promote self-medication through purchasing drugs at Japanese pharmacies.  As a result, we hope to contribute to making Japanese pharmacies more foreign user-friendly in a real sense.

著者

清水 忠 西村 奏咲 安田 恵 村上 雅裕 橋本 佳奈 大野 雅子 桂木 聡子 上田 昌宏 天野 学

出版者

日本薬学教育学会

雑誌

薬学教育 (ISSN:24324124)

巻号頁・発行日

vol.2, pp.2018-014, 2018 (Released:2018-08-24)

参考文献数

7

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薬学実務実習終了生を対象としたアンケート調査によれば,大半の学生は実習中に基礎薬学の知識を活用する機会は少なかったと感じていることが報告されている.その要因として,教員が基礎薬学は臨床現場でどのように役に立つかを具体的に説明できていないことが指摘されている.しかし,臨床現場での問題は基礎薬学が問題解決に有用となることもある.そのため,基礎系教員と臨床系教員が連携し基礎薬学の臨床現場での有用性を理解させ,それが可能であることを示すことが必要であると考えた.そこで,実務実習事前学習において有機化学を専門とする基礎系教員と実務家教員が連携した医薬品の配合変化に関する実習を実施し,終了後にアンケートを行った.この結果,受講生の90%以上が基礎薬学の内容が臨床の問題を解決するのに有用であることを意識できた.すなわち,基礎薬学が臨床現場でどのように役に立つかを意識させる実習を提供できたと考えられる.

著者

村上 雅裕 三浦 友里 桂木 聡子 大野 雅子 天野 学 森山 雅弘

出版者

Japanese Society of Drug Informatics

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.17, no.3, pp.140-144, 2015 (Released:2015-12-18)

参考文献数

5

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Objective: For pharmacists to select a suitable auxiliary device for eye drop administration for patients who have difficulty in applying eye drops, the pharmacists need to know the characteristics and level of difficulty of using each device.Methods: Thus, we compared the characteristics of New Rakuraku Tengan, Rakuraku Tengan III, and an eye-drop self-help device and also conducted a survey involving 40 healthy volunteers on each device’s accessibility and suitability for people with motor disabilities.Results: New Rakuraku Tengan received the highest score for “usage was able to easily understand” (70.0% of the respondents answered positively) and “suitability for poor-sighted people” (65.0%).  Rakuraku Tengan III received the highest score for the “effectiveness of photos and illustrations in the manual” (77.5%), but was evaluated to be difficult to use.  The eye-drop self-help device received the highest score for “suitability for people with difficulty raising their shoulders and arms” (75.0%).Results: Thus, we observed the need for pharmacists to have thorough knowledge of the products in order to recommend suitable auxiliary devices for eye drop administration for each patient.

著者

林 輝明 上田 昌宏 中澤 公揮 橋本 佳奈 桂木 聡子 天野 学 清水 忠

出版者

一般社団法人 日本薬学教育学会

雑誌

薬学教育 (ISSN:24324124)

巻号頁・発行日

vol.6, pp.2021-039, 2022 (Released:2022-05-13)

参考文献数

10

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基礎実習や臨床事前実習の学習効果を向上させるためには,受講生が既に学習済の内容が実習内容と繋がっているかを予習し,関連する部分の知識を整理した上で実習に取り組むことが望ましい.我々は,臨床事前実習コースの化学的な知識を踏まえた配合変化の学習において,チーム基盤型学習(TBL)を導入し,応用演習の部分に実習を位置づけた方略を構築した.授業終了後に行ったアンケートの因子分析およびクラスター分析の結果から,臨床に関連する化学的な知識に自信がなくてもTBLを経験することによって,実習内容が理解できたと実感している可能性が示された.TBLと実習を組み合わせた本授業方略が,化学的な知識と臨床を繋ぐ実習内容の理解度を高める可能性のあるプログラムであることが示唆された.

著者

中山 雅裕 濱田 昌志 深津 佳代 門林 宗男 大野 雅子 桂木 聡子 天野 学 森山 雅弘

出版者

一般社団法人日本医薬品情報学会

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.17, no.1, pp.11-14, 2015 (Released:2015-06-28)

参考文献数

10

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Objective: In Japan, to prevent an increase in medical expenditure associated with development of super-aging society, the use of generic drugs is being promoted.  To help patients financially and meet their various other needs, generic drugs (e.g., orally disintegrating film formulations) whose dosage forms do not exist for original drugs are manufactured and distributed.  In this study, to evaluate the characteristics of an orally disintegrating film formulation, we performed dissolution, disintegration, and simulated intraoral tests of Amlodin® tablets 2.5 mg, Amlodin® OD tablets 2.5 mg, and Amlodipine OD film 2.5 mg that were manufactured by TEVA-KOWA PHARMA Co., Ltd.Methods: Dissolution and disintegration tests were performed in line with the Japanese Pharmacopoeia, Sixteenth Edition, and the dose of amlodipine was determined by high-performance liquid chromatography.  During the simulated intraoral test, the tested drugs’ disintegration in purified water and artificial saliva was observed macroscopically, and recorded using a digital camera.Results: Since the each formulation showed an over 85.0% rate of dissolution 15 min after the initiation of the dissolution test, no difference was found in elution behavior.  Also, in the simulated intraoral test, the film formulation began to disintegrate the earliest (2 and 10 min when using purified water and artificial saliva, respectively) among the tested drugs.Conclusion: Our findings suggest that orally disintegrating film formulations show superior disintegration to uncoated or orally disintegrating tablets, and benefits on taking medicine was observed.