著者

兵頭 政光 小林 丈二 山形 和彦 森 敏裕

出版者

Japan Society for Head and Neck Cancer

雑誌

頭頸部腫瘍 (ISSN:09114335)

巻号頁・発行日

vol.27, no.3, pp.671-677, 2001-11-25 (Released:2010-04-30)

参考文献数

14

被引用文献数

1

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口腔および中咽頭癌切除再建後の嚥下および構音機能に関し、嚥下圧検査および発語明瞭度から検討を行った。嚥下圧は口蓋切除後には軟口蓋圧がわずかに低下したが、義顎を装用することでほぼ正常に回復した。中咽頭側壁切除では軟口蓋から中咽頭の圧が低下した。舌半側切除および亜全摘では、術後早期には正常の嚥下圧が得られる例が多かったが、経時的には術後の皮弁萎縮により嚥下圧が低下した。また、中咽頭と下咽頭での圧の同時発生や嚥下反射に先立つ口腔内の小刻みな舌運動を示す所見も認められたが、経過とともに改善傾向を示した。構音機能では口蓋切除後には発語明瞭度は著しく低下したが、口蓋欠損部を義顎により閉鎖すると改善した。中咽頭側壁切除後には軟口蓋音の障害が認められた。舌半側切除後には構音機能はあまり障害されないのに対し、亜全摘では声門音以外のすべての音の障害が高度であった。

著者

小林 丈二 佐伯 忠彦 竹田 一彦 上甲 英生

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.89, no.11, pp.1365-1369, 1996-11-01 (Released:2011-11-04)

参考文献数

14

被引用文献数

1 2

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The authors investigated the clinical course of 49 patients with peritonsillar abscesses treated at Uwajima City Hospital between January 1983 and December 1995. The cohort consisted of 36 males and 13 females, aged 15 to 68 (mean age, 37.2 years old). Along with administration of antibiotics, removal of the abscess was performed by needle aspiration in 25 cases, and incision for drainage in 24 cases, respectively. There were no statistical differences in clinical stage and course between the group under 40 years old and the group over 40 years old. There was also no difference between the group treated with needle aspiration and the group treated with incision, except for the length of hospital stay healing time. Interval tonsillectomy was carried out in 10 cases. Recurrence of the peritonsillar abscess occurred in only one case. Therefore, we recommend needle aspiration as the first choice for treatment of peritonsillar abscesses. In cases of peritonsillar abscess with no past history of habitual angina, tonsillectomy is not indicated because recurrence of peritonsillar abscesses is rare.

著者

西村 信弘 土井 教雄 上村 智哉 竹谷 健 林 丈二 葛西 武司 金井 理恵 山口 清次 岩本 喜久生 直良 浩司

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.129, no.6, pp.759-766, 2009 (Released:2009-06-01)

参考文献数

21

被引用文献数

4 5

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A traditional Chinese herbal medicine, Kampo medicine, maoto, has been widely used in the treatment of febrile symptoms caused by viral infection. This herbal extract granule for oral use, however, is not well accepted by infants or young children due to its unpleasant taste and odor. Therefore, we prepared Kampo medicine, maoto, suppository and investigated the pharmaceutical and clinical efficacy of the suppository. Kampo medicine, maoto, granules were micro-pulverized and homogeneously dispersed into Hosco-H15 to prepare suppositories containing 0.25 to 1.0 g herbal extract by the conventional fusion method. Content of l-ephedrine, an index compound of Kampo medicine, maoto, in the extract granules and suppositories was determined by using a high performance liquid chromatographic method. Physicochemical experiments revealed that the suppository containing 0.5 g herbal extract had the most suitable melting point of 34°C. Contents of l-ephedrine in the suppository were constant, 93-96% of those in the same amount of the extract granules in different three lots. Upper and lower portions of the suppository had the same content of l-ephedrine. The suppository maintained more than 95% of l-ephedrine content through 6 months at 4°C, room temperature and 40°C, although maldistribution of the extract constituent was observed after storage at 40°C. The suppository was administered to 21 pediatric febrile patients at a dose of 1/3 to 2 full pieces depending on their body weight and physical status. Significant reduction (p<0.001) of body temperature from 39.5 to 37.5°C without serious adverse effects was observed in 17 patients who were monitored the clinical effects on the febrile symptoms. In conclusion, Kampo medicine, maoto, suppository was found to satisfy the physicochemical quality and quantity standards as well as to be clinically applicable to neonates, infants and children with viral febrile symptoms without any adverse effects.