- 著者
- 梅津 亮冴 西端 友里 阿部 純子 鈴木 悠起也 原 英彰 永澤 秀子 紀ノ定 保臣 中村 光浩
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- YAKUGAKU ZASSHI (ISSN:00316903)
- 巻号頁・発行日
- vol.134, no.2, pp.299-304, 2014 (Released:2014-02-01)
- 参考文献数
- 22
- 被引用文献数
- 11 17
Hypoglycemia due to treatment with oral anti-hyperglycemic agents (OHAs) is a major clinical problem in patients with type 2 diabetes mellitus. The aim of the present study was to evaluate the risk of hypoglycemia due to OHA use by using the Japanese Adverse Drug Event Report (JADER) database. To this end, reports of hypoglycemia events included in the JADER database between 2004 and 2012 were analyzed by calculating the reporting odds ratio (OR). The Medical Dictionary for Regulatory Activities Preferred Terms was used to identify hypoglycemia; 254392 reports were found in the JADER database, of which 13269 were excluded because the age and sex of the patient were not reported. Finally, 241123 reports were analyzed. Among OHAs, sulfonylureas showed the highest adjusted OR (adjusted OR, 10.13; 95% confidence interval, 9.08-11.26). The adjusted ORs for meglitinides, biguanide, thiazolidinedione, alpha-glucosidase inhibitors, and dipeptidyl peptidase-4 inhibitors were significantly lower than that of sulfonylureas. The adjusted OR of meglitinides (3.17; 95% confidence interval, 2.23-4.36) was significantly higher than that of alpha-glucosidase inhibitors or thiazolidinedione. We observed no difference between the adjusted ORs for biguanide, thiazolidinedione, alpha-glucosidase inhibitors, and dipeptidyl peptidase-4 inhibitors. Data mining of the JADER database was useful for analyzing OHA-associated hypoglycemia events. The results of our study suggested a low risk of hypoglycemia associated with biguanide, thiazolidinedione, alpha-glucosidase inhibitors, and dipeptidyl peptidase-4 inhibitors in clinical practice.
1 0 0 0 付加・脱離型反応を利用する四級炭素の不斉構築に関する研究
1 0 0 0 OA 局所腫瘍制御と遠隔転移抑制を同時に目指す腫瘍内微小環境解析とその応用
遠隔転移能と、休止期腫瘍細胞の殺細胞効果も加味した腫瘍制御効果を同時に評価するアッセイ系を確立し、腫瘍内急性低酸素を解除する処置が腫瘍からの肺転移を抑え、中性子捕捉療法では、慢性低酸素の大きな休止期腫瘍細胞に分布できるBSHを用いると局所腫瘍制御が向上し、急性低酸素細胞に分布可能なBPAを用いると遠隔転移能が抑制される事が判明した。酸素化休止期腫瘍細胞の感受性を検出可能な手法も確立し、休止性と高いDNA損傷からの回復能の点で癌幹細胞との共通性が認められた。腫瘍内不均一性に依存して分布するBPAのCBE値は変化しやすく、この値が腫瘍の不均一性の評価のための有望な指標になり得る事も判明した。