著者

梅津 亮冴 西端 友里 阿部 純子 鈴木 悠起也 原 英彰 永澤 秀子 紀ノ定 保臣 中村 光浩

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.134, no.2, pp.299-304, 2014 (Released:2014-02-01)

参考文献数

22

被引用文献数

11 17

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Hypoglycemia due to treatment with oral anti-hyperglycemic agents (OHAs) is a major clinical problem in patients with type 2 diabetes mellitus. The aim of the present study was to evaluate the risk of hypoglycemia due to OHA use by using the Japanese Adverse Drug Event Report (JADER) database. To this end, reports of hypoglycemia events included in the JADER database between 2004 and 2012 were analyzed by calculating the reporting odds ratio (OR). The Medical Dictionary for Regulatory Activities Preferred Terms was used to identify hypoglycemia; 254392 reports were found in the JADER database, of which 13269 were excluded because the age and sex of the patient were not reported. Finally, 241123 reports were analyzed. Among OHAs, sulfonylureas showed the highest adjusted OR (adjusted OR, 10.13; 95% confidence interval, 9.08-11.26). The adjusted ORs for meglitinides, biguanide, thiazolidinedione, alpha-glucosidase inhibitors, and dipeptidyl peptidase-4 inhibitors were significantly lower than that of sulfonylureas. The adjusted OR of meglitinides (3.17; 95% confidence interval, 2.23-4.36) was significantly higher than that of alpha-glucosidase inhibitors or thiazolidinedione. We observed no difference between the adjusted ORs for biguanide, thiazolidinedione, alpha-glucosidase inhibitors, and dipeptidyl peptidase-4 inhibitors. Data mining of the JADER database was useful for analyzing OHA-associated hypoglycemia events. The results of our study suggested a low risk of hypoglycemia associated with biguanide, thiazolidinedione, alpha-glucosidase inhibitors, and dipeptidyl peptidase-4 inhibitors in clinical practice.

著者

笹岡 沙也加 松井 利亘 阿部 純子 梅津 亮冴 加藤 大和 上田 夏実 羽根 由基 元岡 佑美 畠平 春奈 紀ノ定 保臣 中村 光浩

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.136, no.3, pp.507-515, 2016-03-01 (Released:2016-03-01)

参考文献数

27

被引用文献数

11 14

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The Japanese Ministry of Health, Labor, and Welfare lists hand-foot syndrome as a serious adverse drug event. Therefore, we evaluated its association with anticancer drug therapy using case reports in the Japanese Adverse Drug Event Report (JADER) and the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS). In addition, we calculated the reporting odds ratio (ROR) of anticancer drugs potentially associated with hand-foot syndrome, and applied the Weibull shape parameter to time-to-event data from JADER. We found that JADER contained 338224 reports from April 2004 to November 2014, while FAERS contained 5821354 reports from January 2004 to June 2014. In JADER, the RORs [95% confidence interval (CI)] of hand-foot syndrome for capecitabine, tegafur-gimeracil-oteracil, fluorouracil, sorafenib, and regorafenib were 63.60 (95%CI, 56.19-71.99), 1.30 (95%CI, 0.89-1.89), 0.48 (95%CI, 0.30-0.77), 26.10 (95%CI, 22.86-29.80), and 133.27 (95%CI, 112.85-157.39), respectively. Adverse event symptoms of hand-foot syndrome were observed with most anticancer drugs, which carry warnings of the propensity to cause these effects in their drug information literature. The time-to-event analysis using the Weibull shape parameter revealed differences in the time-dependency of the adverse events of each drug. Therefore, anticancer drugs should be used carefully in clinical practice, and patients may require careful monitoring for symptoms of hand-foot syndrome.

著者

会田 久仁子 阿部 純子 角野 幸子 山塙 圭子 遠藤 英子 角野 猛 山田 幸二

出版者

日本食生活学会

雑誌

日本食生活学会誌 (ISSN:13469770)

巻号頁・発行日

vol.10, no.2, pp.70-74, 1999

被引用文献数

1

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We analyzed the various component and bacteria of Home-made Izushi in Hokkaido Area.<BR>The results were as follows:<BR>1. The averages of contents of salt and potassium, and water activity of Home-made Izushi were 2.3%, 121mg/100g and 0.941, respectively.<BR>2. The total amounts of free amino acids of Izushi were 540mg/100g-2522mg/100g.<BR>The major free amino acids of Izushi were glutamic acid, alanine, leucine, anseline and lysine.<BR>3. Major fatty acids composition of Izushi were C18:1, C16:0 and C18:3.<BR>4. Mean bacterial counts and lactic acid bacteria of Izushi were 6.168/log/g and 6. 598/log/g, respectively.Coliform organisms, E.coli, Staphylococcus aureus and Salmonella were not detected from Izushi.

著者

岡崎 怜子 宮内 靖史 小林 義典 丸山 光紀 岩崎 雄樹 平澤 泰宏 阿部 純子 谷口 宏史 堀江 格 舘岡 克彦 上野 亮 小鹿野 道雄 篠田 暁与 小原 俊彦 平山 悦之 加藤 貴雄 高野 照夫 新田 隆 大森 裕也

出版者

公益財団法人 日本心臓財団

雑誌

心臓 (ISSN:05864488)

巻号頁・発行日

vol.37, no.4, pp.115-122, 2005

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症例は74歳,女性.70歳時に僧帽弁置換術および慢性心房細動に対しradial手術施行.手術2カ月後より周期220msの心房頻拍(AT)が持続.AT中,冠静脈洞(CS)の興奮順序は遠位から近位であり,CS内広範囲でpost-pacing interval(PPI)が頻拍周期にほぼ一致するconcealed entrainment(CE)を認めたことから僧帽弁輪を旋回するATと考えた.左房後壁切開線が接合する僧帽弁輪部直下のCS内部にて波高の高い電位が記録され,PPIが頻拍周期に一致するCEを認めた.同部位における高周波通電開始4秒後に頻拍は停止し,以後誘発不能となった.通電部位より2mm近位部でのペーシングで1cm遠位部への伝導時間が200msとなったことからこの通電で左房後壁切開のブロックが完成したと考えた.術中完全に凍結し得なかったCS筋層を介する伝導が頻拍発生の原因と考えられたradial術後ATを経験したので報告する.

著者

長谷川 栞 畠平 春奈 長沼 美紗 島内 あかり 笹岡 沙也加 元岡 佑美 福田 昌穂 阿部 純子 中尾 智史 加藤 大和 大森 智史 井口 和弘 中村 光浩

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.137, no.10, pp.1301-1311, 2017-10-01 (Released:2017-10-01)

参考文献数

36

被引用文献数

2 3

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OTC drugs play an important role in self-medication. OTC analgesic and antipyretic drugs are widely used in Japan. The present study aimed to survey the components of OTC drug package inserts for analgesic and antipyretic drugs and to evaluate the adverse event profiles using the Japanese Adverse Drug Event Report database (JADER). The JADER contains 430587 reports from between April 2004 and November 2016; a total of 750 reports of adverse events resulted from the use of OTC analgesic and antipyretic drugs. The safety signals were detected by the reporting odds ratio (ROR). The ROR values for “Skin & subcutaneous tissue disorders”, “Immune system disorders”, and “Hepatobiliary disorders” stratified by system organ class of the Medical Dictionary for Regulatory Activities (MedDRA) were 7.58 (6.56-8.76), 4.25 (3.51-5.14), and 2.35 (1.93-2.85), respectively. OTC analgesic and antipyretic drugs containing allylisopropylacetylurea (AIAU) exhibited a significantly high reporting ratio of “Skin & subcutaneous tissue disorders” compared with the drugs without AIAU. No difference in the reported incidence of “Hepatobiliary disorders” was found between the drugs with or without acetaminophen. Our results suggested that it was important to monitor patients who use OTC analgesic and antipyretic drug containing AIAU; in particular, careful attention should be paid to skin and subcutaneous tissue disorders.

著者

梅津 亮冴 阿部 純子 上田 夏実 加藤 大和 中山 蓉子 紀ノ定 保臣 中村 光浩

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.135, no.8, pp.991-1000, 2015 (Released:2015-08-01)

参考文献数

19

被引用文献数

3 7

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Over-the-counter (OTC) drugs play an important role in self-medication. To ensure patient safety, pharmacists should ask patients to pay attention to possible adverse events (AE) associated with OTC drugs and educate patients about the symptoms related to those AEs. The aims of the present study were as follows: (1) to assess the tendency of AEs to occur with OTC drug use in Japan; (2) to detect a safety signal for OTC drugs using the reporting odds ratio (ROR); and (3) to evaluate clustery features, which include suspected drugs and therapeutic classifications, and safety signal indices (number of reports and the ROR), using cluster analysis. The number of reports of AEs following use of combination cold remedy, antipyretic and analgesic remedy, and herbal medicine was 1007, 566, and 221, respectively. We set the cluster number at five; clustery features obtained were as follows: (1) high reporting rate for skin and subcutaneous tissue disorder AEs was the largest group related to combination cold remedy; (2) high reporting rate for nervous system disorder AEs including dizziness was the second largest group. The same medicinal ingredient may demonstrate similar tendencies of the occurrence of AEs and similar clustery features in the Japanese Adverse Drug Event Report database. Our analysis of AEs associated with OTC drugs may be useful for pharmacists and patients alike. Further studies are required to draw better-informed conclusions.