著者

渡辺 俊明 田中 正彦 渡邉 和俊 高松 康雄 戸部 昭広

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.124, no.3, pp.99-111, 2004-03-01 (Released:2004-02-25)

参考文献数

51

被引用文献数

84 86

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Increasing data suggest that oxygen free radical species play detrimental roles in ischemic diseases. A free radical scavenger capable of inhibiting oxidative injury is expected to become a new drug for the treatment of ischemic diseases such as cerebral ischemia. Edaravon (3-methyl-1-phenyl-2-pyrazolin-5-one), which has been developed as an neuroprotective agent for more than 15 years since its discovery, is approved for the treatment of acute cerebral infarction. In this paper, the pharmacologic characteristics and clinical effects of edaravone are reviewed. In early stage of investigation, edaravone was found to have promising activities as an antioxidative radical scavenger, quenching hydroxyl radical (•OH) and inhibiting both •OH-dependent and •OH-independent lipid peroxidation. Edaravone showed inhibitory effects on both water-soluble and lipid-soluble peroxyl radical-induced peroxidation systems, which are different from the inhibitory effects of vitamins C and E in each system, respectively. Oxidative injury to cultured endothelial cells caused by arachidonate (AA) peroxides is prevented in the existence of edaravone. To clarify the characteristics of this free radical scavenger, further investigation was carried out. Edaravone ameliorated exacerbation of cortical edema induced by a focal ischemia-reperfusion model in rats, suggesting inhibitory effects on oxidative injury to the blood-brain barrier (BBB). Additionally, edaravone also prevented rat cortical edema caused by intracortical AA infusion in which free radical production and subsequent oxidative injury to the BBB are involved. With advances in in vivo measurement technology of oxygen radicals, edaravone was shown to inhibit postischemic increases in •OH production and tissue injury in the penumbral or recirculated area in rat cerebral ischemia models. In clinical studies, edaravone improved the core neurologic deficits, activities of daily living, and functional outcome of stroke patients. Furthermore, a study using proton magnetic resonance spectroscopic techniques showed that edaravone preserved N-acetyl-aspartate in stroke patients, a promising neuronal marker in the brain. Further investigation is essential for a better understanding of free radical-mediated cerebral injury during ischemia followed by recirculation. We hope that edaravone represents a promising neuroprotectant for drug therapy in acute cerebral ischemia.

著者

古田 茂 石原 矩武 東本 暁美 渡辺 俊明

出版者

The Textile Machinery Society of Japan

雑誌

繊維機械学会誌 (ISSN:03710580)

巻号頁・発行日

vol.52, no.6, pp.T88-T95, 1999-06-25 (Released:2010-02-01)

参考文献数

9

被引用文献数

1 1

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To establish highly automated leather finishing process, it is necessary to develop the leather handling robot system which are provided with automatic aligned stacking and feeding functions of side-leather for loading and unloading to leather finishing machines. The robot system are composed of manipulation hand with vacuum pad and image processing system to recognize the shape patterns of side-leather for aligning functions. For the image processing, 2 types of sensors are applied. They are CCD camera for the recognition of shape patterns and other one is luster sensor to detect grain or flesh side. By applying the developed shape patterns recognition algorithms to the image processing system, side-leather discriminations of grain or flesh, head or tail, belly or back were carried out perfectly. As the result, the handling robot aligned side-leathers with following 2 stacking methods.1) Stacking with left and right side along the backbone (LR method).2) Stacking with grain to grain (GG method).Also, investigated on the robot hand to hold correctly each 1 leaf from stacked up side-leathers on the table.

著者

渡辺 俊明 小川 健治 勝部 隆男 平井 雅倫 矢川 裕一 梶原 哲郎

出版者

東京女子医科大学学会

雑誌

東京女子医科大学雑誌 (ISSN:00409022)

巻号頁・発行日

vol.61, no.12, pp.1092-1092, 1991-12-25

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第11回学内免疫談話会 平成3年7月6日 東京女子医科大学臨床講堂I