著者

丹羽 靱負 渡部 誠一郎

出版者

日本DDS学会

雑誌

Drug Delivery System (ISSN:09135006)

巻号頁・発行日

vol.4, no.2, pp.111-119, 1989-04-10 (Released:2009-02-23)

参考文献数

42

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Bovine liposomal-encapsulated superoxide dismutase (L-SOD) which was developed by A. M. Michelson has overcome the pharmacobiochemical problems (disadvantages) of the injection of SOD preparations ; the very short life span of free SOD (6 min) was to considerable extent prolonged (6-7 hr), and weak fixation and penetration (permeability) to the membranes of target cells where oxygen radicals or lipid peroxides are exerting their harms. As previously reported by us, the injection (2.5 mg twice a week) of L-SOD was markedly effective in Kawasaki's disease (mucocutaneous lymph node syndrome), intestinal ulcer of Behçet's disease, Crohn's disease and colitis ulcerosa, and lung fibrosis of progressive systemic sclerosis (PSS) and polymyositis (dermatomyositis). In addition, severe rheumatoid arthritis (RA), Sjögren syndrome and other oxygen radical-or lipid peroxide-related diseases are improved by L-SOD injection. Recently, it has been further found that L-SOD (1.5 mg twice a week) is effective in liver cirrhosis, fibrosis induced by radiation, and schizophrenics. Acute paraquat toxicosis taken for the purpose of suicide which had been completely beyond the treatment was well treated with continuous drip infusion of L-SOD. Skin ulcer lesions were also in shorter period healed and keloid formation was prevented with L-SOD injection. However, not only other free SOD preparations but also L-SOD have various problems and questions in their pharmacologic and biochemical actions in the body to be solved or to be answered. In animal experiment, it was verified that SOD does not work dose-dependently, but the dosis over optimal concentration adversely stimulate and increase inflammation. It has been the great question why only a very small amount of enzyme (1.5 mg twice a week) actually and effectively prevents inflammation ; this dosis is 1/20 to 1/150 of the SOD which usually exists in each tissue or organ in the body. Next, it is also the great question why allogeneic (human) SOD is ineffective in the diseases while heterogeneic (bovine) SOD is effective. Although in part answered by us1, 7) and Michelson, why heterogeneic SOD has shown no severe allergy such as anaphylaxis? Further, regarding the clinical effectiveness of L-SOD in Behçet's disease, why L-SOD is ineffective in ocular type while it is dramatically effective in intestinal type? SOD preparations including L-SOD, although they seem to be actually recommendable for the various inflammatory diseases, there have been several problems to solved, and L-SOD is also still required to be improved, Additionally, it is not unlikely that allogeneic (human) SOD preparations are clinically effective in the diseases.

著者

渡部 誠一 杉原 素子

出版者

一般社団法人 日本作業療法士協会

雑誌

作業療法 (ISSN:02894920)

巻号頁・発行日

vol.38, no.3, pp.314-324, 2019-06-15 (Released:2019-06-15)

参考文献数

29

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我が国の調査では,長期入院統合失調症患者のうち20〜50%は退院意向を示さないとされ,厚生労働省は,「退院に向けた意欲の喚起」を強調している.本研究では,長期入院統合失調症患者の退院意向に関連する個人因子を明らかにする目的で,精神科病院に1年以上入院している統合失調症患者50名を対象に,退院意向質問紙,将来への否定的自己評価であるDefeatist Beliefsおよび陰性症状を横断的に評価した.その結果,Defeatist Beliefsは退院を示さない群において有意に重度で(p=0.001),交絡因子を含めても有意な関連が認められた(p=0.01).本結果により,退院意向を示さない統合失調症患者の退院への意欲喚起には,心理社会的介入の重要性が示唆された.

著者

渡辺 章充 南風原 明子 黒澤 信行 渡部 誠一

出版者

THE JAPANESE ASSOCIATION OF RURAL MEDICINE

雑誌

日本農村医学会雑誌 (ISSN:04682513)

巻号頁・発行日

vol.59, no.5, pp.591-594, 2011-01-30

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ロタウイルス感染に伴う急性脳症を2例経験した。<br>〔症例1〕2歳11か月の女児で全身強直間代性けいれんで発症した。人工呼吸管理まで要したが,後遺症なく回復した。<br>〔症例2〕2歳2か月の女児で不機嫌状態が遷延し,脳波の徐波化,頭部MRIで小脳に異常信号を認めた。運動機能は回復したが,高次脳機能と軽度の小脳症状が残った。<br> ロタウイルスによる脳症には,けいれん発作主体のものだけでなく,小脳に主病変を示すタイプがある。前者は診断・治療とも他のウイルス性急性脳症に準ずることで大きな問題はないが,後者は早期診断に苦慮することもあり,また,有効な治療法も確立されていない。