著者

玉利 祐三 土屋 和幸

出版者

一般社団法人 日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.15, no.3, pp.248-258, 2004 (Released:2005-04-08)

参考文献数

20

被引用文献数

3

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Lithium content of the ocean fish has been investigated for estimating the intake of lithium, which was known as an element being used to a medicine (lithium carbonate) for the remedy of manic-depressive psychosis. In this study, fish (184 samples) was classified commercially into three types; raw fish (n=95), dry fish (n=70) and canned fish (n=19). Lithium content was determined by flame photometry after the decomposition of a fish sample (∼ 2g) with the mixture of nitric and perchloric acids. In the raw fish, lithium content was obviously higher in a sardine group (264 ± 186 ng/g in the range of 67 ∼ 934 ng/g, n=51) than in the other fish group (38 ± 28 ng/g in the range of 11 ∼ 86 ng/g, n=44, at wet-weight basis). Especially in the sardine group, the content was higher in anchovy (407 ± 167 ng/g, n=25) than in others (e. g., big-eye sardine; 85 ± 12 ng/g, n=11 and Japanese pilchard; 157 ± 43 ng/g, n=6, at wet-weight basis). In addition to the sardine group (anchovy, pilchard, sardine and blue sprat) rich lithium was found in the head (40 ∼ 66% of total lithium), compared with the eyes (0.1 ∼ 1%), internal organ (1 ∼ 9%), body (10 ∼ 33%) and back bone (15 ∼ 36%) of the fish. On the other hand, in dry fish, lithium was rich in the anchovy of “Niboshi” (5390 ng/g, as mean, n=30, at dry-weight basis) among dry sardine; manufactured as “Niboshi”, “Tazukuri”, “Maruboshi”, “Namaboshi” and “Chirimen” named for depending on their different drying-treatments in Japan. Lithium content of raw anchovy, 407 ± 167 ng/g (n=25) at wet-weight basis, was converted to 1770 ± 727 ng/g (n=25) at dry-weight basis, and the value was close to 2440 ± 657 ng/g (n=9) of dry anchovy as “Tazukuri” at dry-weight basis. The lithium content of canned sardine soaked with oil (sardine fillet: 246 ± 135 ng/g, n=15, at wet-weight basis) was close to that with water (sardine fillet: 123 ± 62 ng/g, n=3, at wet-weight basis), and was almost equal to that of raw sardine group (264 ± 186 ng/g, n=51, at wet-weight basis). It was concluded that anchovy and sardine, regardless of raw, dry or canned fish and of different ocean of the fish collected, were good material for the intake of lithium.

著者

玉利 祐三

出版者

一般社団法人 日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.16, no.3, pp.250-257, 2005 (Released:2006-04-20)

参考文献数

26

被引用文献数

1

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Lithium carbonate is known as medical supplies for the remedy or prevention of manic-depressive psychosis. Blood lithium concentrations of their patients generally should be monitored during their hospital-treatments not to beyond the toxic concentration level of lithium. When heparin is usually added to a blood sample for preventing the blood-coagulation, impurity lithium of the reagent gives a positive error for the determination of lithium concentration of the blood. In this work the lithium concentration was determined by flame photometry after the decomposition of a sample with nitric-perchloric acids or hydrofluoric-nitric-perchloric acids for food samples. In the chemicals used for anticoagulant it was found that sodium citrate, heparin sodium salt and EDTA-2Na contained high amounts of lithium as impurity; 422, 221and 204 ng/g, respectively, whereas lithium was not detected in EDTA-4H and citric acid. Impurity lithium content of chemicals of general salt of sodium, potassium, magnesium and calcium were also tested; there was a fact that considerable amounts of lithium, 39500 and 14000 ng/g, existed in high purity of calcium metal and its carbonate. The Li/Ca ratio of the content of calcium salt (chemicals, n=36) was almost constant, and there was a good correlation between lithium and calcium content. The same tendency of the constant ratio of Li/Ca for the chemicals was also found in natural carbonate minerals of calcite, dolomite and aragonite, and biological materials of human milk, human serum, mammalian bone and oyster shell. On the other hand, lithium concentrations of plasma of healthy Japanese and Korean female were investigated, and the relationship between plasma lithium concentration and daily dietary lithium intake of the healthy people at urban district and village near seashore were also investigated in Korea. There was no significant difference between dietary lithium intake and plasma lithium concentration for the healthy people. Plasma lithium concentration was almost constant to be 11±2 ng/g (n=164) for healthy people.

著者

玉利 祐三 土屋 和幸 宇野澤 景子 吉川 之菜 Yuzo Tamari Kazuyuki Tsuchiya Keiko Unozawa Shina Yoshikawa

出版者

甲南大学

雑誌

甲南大学紀要. 理工学編 = Memoirs of Konan University. Science and engineering series (ISSN:13480383)

巻号頁・発行日

vol.52, no.2, pp.167-188, 2005-12-25

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The trace lithium content of different kinds of samples was determined by flame photometry using the atomic absorption spectrophotometer with air-acetylene flame at the optimum instrumental conditions, after the decomposition of a sample with nitricperchloric acid mixture or the decomposition of a freeze-drying food sample with nitric-perchloric-hydrofluoric acid mixture. In the highpurity chemicals lithium content as impurity was considerably higher in calcium salt (metal: 39500ng/g, oxide: 21500ng/g, carbonate: 13700〜14400ng/g) than in magnesium (11〜67ng/g), sodium (198〜634ng/g) and potassium salt (196〜361ng/g). In the carbonate minerals the content was higher in aragonite (av. 21970ng/g) and calcite (av. 14100ng/g) than in dolomite (av. 9959ng/g) depending on calcium content as a matrix component. In the table-salt samples of sea-, lake- and rock-salt the content was 934, 724 and 870ng/g, respectively, and the lithium content was summarized to be 900ng/g as mean for all the 34 samples. In the rice the content was three times higher than in unpolished rice av. 12.7ng/g than in polished rice av. 5.2ng/g. Finally in the cow's milk the content was almost constant to be av. 23.7ng/g regardless with the different fat-content, pasteurized temperature and manufactured district (Prefecture in Japan). In addition to an annual variation of the lithium content of a same brand of cow's milk the content was also almost constant to be av. 24.3ng/g, regardless of four seasons.

著者

日下 譲 辻 治雄 玉利 祐三 西村 公男 藤原 儀直

出版者

日本陸水学会

雑誌

陸水学雑誌 (ISSN:00215104)

巻号頁・発行日

vol.45, no.2, pp.93-99, 1984-04-30 (Released:2009-11-13)

参考文献数

5

被引用文献数

2

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Chemical species of the shallow groundwaters collected from the Arima rhyolite strata around Sanda and Nishiwaki cities are studied. Since the chemical composition of the igneous effusive rock is reasonably representative of rocks of the continental crust, the water quality is important from the geochemical and environmental viewpoints. The concentrations of 28 chemical species, pH and ER are determined by conventional chemical and neutron activation analyses. By showing log-normal distribution character of the concentrations, the median value schematically obtained in the frequency distribution curve is proposed as most suitable as the chemical composition of groundwaters in the strata. It is also pointed out that the CO2 weathering process is the most dominant phenomenon controlling the water qualities.

著者

玉利 祐三

出版者

公益社団法人日本分析化学会

雑誌

分析化学 (ISSN:05251931)

巻号頁・発行日

vol.48, no.4, pp.435-440, 1999-04-05

被引用文献数

6 3

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微量リチウムの生体必須性が指摘されるなかで, リチウムが内分泌器官と関連していることが論議されている. 本研究では, 乳児のリチウム摂取量を把握するために, 乳児用調製粉乳中のリチウムを原子吸光分光光度計を用いるフレーム分析により定量する方法を検討した. 試料を硝酸・過塩素酸により加熱分解し, 測定溶液を0.1mol/l塩酸酸性とした. 共存する高濃度のナトリウム及びカリウムの影響なしにリチウムが定量できることが分かった. 本法を市販の乳児用調製粉乳16試料に適用したところ, 新生児用では106±13ng/g(p<0.05), 離乳期用では178±42ng/g(P<0.05)となり, アレルギー疾患等の特殊粉乳では118±10ng/g(P<0,05)であった. これらの粉乳中のリチウムの起源は, 含まれる他の成分との濃度相関より, 粉乳に添加されている無機化学薬品中の不純物と推定された. また, 乳児の1日当たりのリチウムの平均摂取量は, 一般の乳児用調製粉乳では12μg, フォローアップミルクでは20μgと算出できた.