1 0 0 0 上顎洞に発生した腺様嚢胞癌に対する集学的治療
- 著者
- 梁川 哲雄 吉田 秀夫 由良 義明 浦田 満 永峰 伸一 佐藤 光信
- 出版者
- 社団法人 日本口腔外科学会
- 雑誌
- 日本口腔外科学会雑誌 (ISSN:00215163)
- 巻号頁・発行日
- vol.32, no.8, pp.1516-1521, 1986
- 被引用文献数
- 1
The most effective treatment for adenoid cystic carcinomas arising from minor salivary glands is surgical removal of primary lesion including the wide safety margin. However, it is well known that the salivary gland tumors have poor prognosis and high frequency of metastasis. Therefore, the multidisciplinary therapy that prevents effectively recurrence and metastasis is needed.<BR>Two cases of adenoid cystic carcinoma of the maxillary sinus were treated according to the follwing multidisciplinary method. Case 1 (T3NOMO by JJC proposal): The patient had surgical removal of the affected maxilla and then radiation therapy. Four weeks later, adjuvant chemotherapy (Adriamycin and Cisplatin) was performed. In addition, UFT and OK-432 were administered continuously up to date from the onset of the treatment. Consequently, the patient remains be disease-free 24 months postoperation. Case 2 (T4NOMO by JJC proposeal): The patient was treated with the multidisciplinary methods such as surgical reduction of a tumor-burden, radiation therapy, intraarterial infusion of cisplatin and 5-FU into a superficial temporal artery and intradermal administration of OK-432. Thereafter, complete regression of the primary tumor was observed. However, metastasis was detected in the regional lymph nodes, which were subjected to radical neck dissection. The patient remains be disease free 8 months postoperation. These findings indicate that the multidisciplinary therapy may improve the prognosis of adenoid cystic carcinoma of the maxillary sinus.
1 0 0 0 OA テリパラチドにより良好な治療結果が得られた広範なビスフォスフォネート関連顎骨壊死の1例
- 著者
- 若林 健 竹内 憲民 楠山 友紀子 山本 汐里 文元 玲子 由良 義明
- 出版者
- 社団法人 日本口腔外科学会
- 雑誌
- 日本口腔外科学会雑誌 (ISSN:00215163)
- 巻号頁・発行日
- vol.61, no.8, pp.424-428, 2015-08-20 (Released:2015-11-24)
- 参考文献数
- 10
- 被引用文献数
- 1 1
We report a case of extensive bisphosphonate-related osteonecrosis of the jaw (BRONJ) associated with a mandibular fracture, which improved after treatment with teriparatide and surgical therapy. An 83-year-old woman was referred to our hospital because of swelling of the submandibular region. At presentation, clinical examination revealed swelling of the right submandibular region and discharge of pus. A computed tomographic (CT) scan confirmed osteolytic changes and a fracture of the mandible. Three months after bone curettage, fixation with a titanic plate, and treatment with teriparatide, new bone formation was observed. Five months after this therapy, the fractured segment had completely healed. Teriparatide may contribute to the improvement of BRONJ.
1 0 0 0 再発頭頚部悪性腫ように対するホウ素中性子捕捉療法
- 著者
- 加藤 逸郎 小野 公二 大前 政利 神田 哲聡 藤田 祐生 大林 茂樹 中澤 光博 丸橋 晃 今堀 良夫 切畑 光統 由良 義明
- 出版者
- Japan Society for Head and Neck Cancer
- 雑誌
- 頭頸部癌 (ISSN:13495747)
- 巻号頁・発行日
- vol.31, no.4, pp.581-586, 2005
- 被引用文献数
- 3
ホウ素中性子捕捉療法(Boron neutron capture therapy: BNCT)は,<SUP>10</SUP>Bを予め腫瘍に集積させ,中性子線照射で発生する粒子線を利用して腫瘍選択的に破壊する治療法である。我々はこの治療法を再発頭頸部悪性腫瘍患者に対し,2001年より世界に先駆けて開始した。対象は扁平上皮癌6例,唾液腺癌3例,肉腫2例の計11例であった。その結果,腫瘍縮小率は,CR:2例,90%以上:5例,73%,54%,PD:1例,NE:1例で,奏功率82%。QOL改善は,潰瘍消失と皮膚再生,PSの改善による仕事復帰,疼痛・開口障害・呼吸苦の改善,生存期間延長などであった。11例中7例(4例:遠隔)に転移を認めた進展例だったが,治療後の生存期間は,1-38ヶ月で平均8.5ヶ月,生存率は36%(4例生存中)であった。副作用は,口内炎,全身倦怠感,脱毛などで軽度だった。進展再発頭頸部悪性腫瘍に対しBNCTを実施し,その有効性を確認した。