著者
小野 秀樹 岡村 真彩 福島 章紘
出版者
公益社団法人 日本薬学会
雑誌
YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日
pp.18-00022, (Released:2018-06-20)
参考文献数
82
被引用文献数
9

The anti-influenza virus drug oseltamivir has been reported to have several pharmacological actions including blocking of nicotinic acetylcholine receptor channels and activation of the dopaminergic system. These pharmacological actions highly overlap those of amantadine, another anti-influenza virus drug authorized in Japan, and ester-type local anesthetics. Moreover, oseltamivir and amantadine can clinically induce similar adverse neuropsychiatric reactions. In the present study, from the database of the Pharmaceuticals and Medical Devices Agency (PMDA), we surveyed 2,576 drugs for which neuropsychiatric side effects similar to those of oseltamivir, amantadine and local anesthetics (abnormal behavior, confusion, consciousness disturbance, convulsion, delirium, delusion, hallucination, myoclonus, tremor) are listed as “clinically significant adverse reactions”, and found 327 that had at least one of these adverse reactions. Other neuraminidase inhibitors (laninamivir, peramivir and zanamivir) did not elicit such adverse reactions. By discussing the pharmacological effects of drugs that elicit these adverse reactions, we propose that the similarity of adverse neuropsychiatric reactions between oseltamivir and amantadine is possibly attributable to their common pharmacological effects.
著者
福島章著
出版者
中央公論社
巻号頁・発行日
1982
著者
福島章著
出版者
PHP研究所
巻号頁・発行日
2002
著者
福島章著
出版者
平凡社
巻号頁・発行日
1987
著者
福島章著
出版者
PHP研究所
巻号頁・発行日
2000
著者
福島 章
出版者
日本医師会
雑誌
日本医師会雑誌 (ISSN:00214493)
巻号頁・発行日
vol.125, no.9, pp.1425-1428, 2001-05-01
著者
福島 章
出版者
医学書院
巻号頁・発行日
pp.169-174, 2001-02-15

疾病論から操作的診断へ 1.疾病論 神経症の概念は,古く18世紀のCullenの命名に遡るが,心因にもとづく心理的障害という近代的な定義は今世紀に入ってからのもので,神経症という上位概念の下に,その後さまざまな類型が命名された。 一方,境界例の概念は,始めは偽神経症性分裂病,潜伏分裂病,外来分裂病,境界状態(分裂病の前後の状態),境界患者(疾病単位)などと呼ばれるなど,その概念は始めから大いに変遷を重ねたが,おおむね,神経症と精神病との「境界」領域と考えられてきた。(このほかに,正常,精神病,人格異常,神経症の4つに跨る境界状態とするSchmidbergの考え方もある)。そして,症状学的にはGundersonらの臨床的な症状の整理や記述,精神力動学にはKernbergの境界人格構造(BPO)の提唱などによってその理解が大いに進められたが,病跡学の領域においてこれらの貢献が活用された例はあまり多いとはいえない。
著者
小野 秀樹 岡村 真彩 福島 章紘
出版者
公益社団法人 日本薬学会
雑誌
YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日
vol.138, no.9, pp.1201-1215, 2018-09-01 (Released:2018-09-01)
参考文献数
82
被引用文献数
9

The anti-influenza virus drug oseltamivir has been reported to have several pharmacological actions including blocking of nicotinic acetylcholine receptor channels and activation of the dopaminergic system. These pharmacological actions highly overlap those of amantadine, another anti-influenza virus drug authorized in Japan, and ester-type local anesthetics. Moreover, oseltamivir and amantadine can clinically induce similar adverse neuropsychiatric reactions. In the present study, from the database of the Pharmaceuticals and Medical Devices Agency (PMDA), we surveyed 2576 drugs for which neuropsychiatric side effects similar to those of oseltamivir, amantadine and local anesthetics (abnormal behavior, confusion, consciousness disturbance, convulsion, delirium, delusion, hallucination, myoclonus, tremor) are listed as “clinically significant adverse reactions”, and found 327 that had at least one of these adverse reactions. Other neuraminidase inhibitors (laninamivir, peramivir and zanamivir) did not elicit such adverse reactions. By discussing the pharmacological effects of drugs that elicit these adverse reactions, we propose that the similarity of adverse neuropsychiatric reactions between oseltamivir and amantadine is possibly attributable to their common pharmacological effects.