著者

糸川 秀治

出版者

東京大学

巻号頁・発行日

1961

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博士論文

著者

相山 律男 永井 久子 沢田 誠吾 横倉 輝男 糸川 秀治 中西 守

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.40, no.10, pp.2810-2813, 1992-10-25 (Released:2008-03-31)

参考文献数

16

被引用文献数

12 16

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Self-association of irinotecan hydrochloride (CTP-11) in an aqueous solution was studied using UV, circular dichroism (CD), 1H-NMR and the quasi-elastic light scattering (QLS) method. The UV spectra showed a hypochromic effect in the aqueous solution. In the CD spectra, typically positive Davydov splitting was observed and the Δε value was reduced sigmoidally when the concentraion of CTP-11 was decreased. In the 1H-NMR, the aromatic signals of higher concentration shifted to a diamagnetic direction compared with those of lower concentration. These observations suggested that CPT-11 molecules are present as monomer in the lower concentration, and the self-association with positive helicity occurs by vertical stacking more than 10 μM of concentration. Its molecules form complete aggregates at more than 2 mM of the concentration. Results of QLS which coincided in the prediction of partition coefficient experiments suggested that CPT-11 molecules formed dimer under the condition. By the regression analysis of CD spectral data, the equilibrium constant for the self-association was calculated to be 2.41×10-4 M-1.

著者

糸川 秀治 竹谷 孝一 一柳 幸生 森田 博史

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.119, no.8, pp.529-583, 1999-08-01 (Released:2008-05-30)

参考文献数

149

被引用文献数

2 10

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A lot of anticancer agents have been isolated from natural sources, especially from microorganisms and plants. However, there is no special type of compounds for cancer therapy. Various types of substances are effective for various types of cancers and tumors : for instance, alka1oids, lignans, terpenes and steroids, etc. In this report, the authors will describe especially about higher plants.

著者

石川 治 橋本 勉 中嶋 暉躬 田中 治 糸川 秀治

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.98, no.7, pp.976-979, 1978-07-25

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For the analysis of Coptidis Rhizoma, high-speed liquid chromatography was examined, not only for its major alkaloid, berberine, but also for its minor alkaloids. It was found that under an appropriate condition [on starch gel (LS-170), eluted with the solvent system of H_2O : MeCN : AcOH : Et_3N=80 : 20 : 0.3 : 0.745,pH 8.5], sufficient separation of berberine, magnoflorine, jatrorrhizine, palmatine, coptisine, and some other unidentified alkaloids was obtained. By means of the present procedure, content of berberine and relative content of palmatine and coptisine to berberine in some of wild and commercial coptis rhizomes were determined. Since the solvent system does not contain any nonvolatile salt, the present technique also offers the possibility of application to rapidpreparative separation of alkaloids of this type by liquid chromatography. The application to analysis of alkaloids of phellodendron-cortex is also described.