著者

藤井 まき子

出版者

日本香粧品学会

雑誌

日本香粧品学会誌 (ISSN:18802532)

巻号頁・発行日

vol.39, no.2, pp.109-113, 2015-06-30 (Released:2016-07-22)

参考文献数

16

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The skin permeation can explain with Fick's diffusion model. Skin concentration depends on partition coefficient between skin and vehicle and concentration in vehicle. However it is changed with various factors, activity of ingredient in vehicle, effect of other ingredients on skin, the change of formulation after application and so on. Thus, if the same concentration of active ingredient is in the formulation, the skin concentration or skin absorption is not always the same. It is important to know the skin penetration and permeation of cosmetic ingredient for the assessment of not only toxicity but also efficacy.

著者

花輪 剛久 藤井 まき子 近藤 直樹 国忠 聡 花輪 正明

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.80, no.1, pp.24-35, 2020 (Released:2020-01-01)

著者

用量設定法ガイドライン検討委員会 藤堂 浩明 足立 浩章 今井 教安 上中 麻規子 内田 崇志 大谷 道輝 澤田 美月 成田 昌稔 西島 貴史 野村 宜史 宮坂 美行 畑尾 正人 増永 卓司 山口 雅彦 佐々 齊 知久 真巳 川田 裕三 古屋 律子 藤井 まき子

出版者

日本香粧品学会

雑誌

日本香粧品学会誌 (ISSN:18802532)

巻号頁・発行日

vol.43, no.2, pp.99-108, 2019-06-30 (Released:2020-06-30)

参考文献数

15

被引用文献数

1

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The skin concentration of topically applied cosmetic active ingredients is very important for evaluating cosmetics. However, a large variation is often observed in finite dose experiments due to the evaporation of volatile components in the formulation and difficulties for applying formulation uniformly. In addition, steady-state skin concentration could not be attained even after several hours of application. In this verification report, we conducted in vitro skin permeation experiment with an infinite dose to confirm whether formulation with the highest skin permeation would also show the highest skin concentration. Three formulations, lotion, milk, and cream, and the mixture of these formulations containing isopropyl methyl phenol (IPMP) as a model ingredient were applied to excised human skin in eight research facilities. The present experiment was conducted with receptor solution containing 1.0% of Brij 98 in order to increase solubility of IPMP in the receptor fluid without changing skin integrity. The obtained results were consistent among the facilities in the following order of skin permeation (lotion>milk>cream≅the mixture) and corresponded with that of the skin concentration. This result showed that evaluation of topical formulations with in vitro skin permeation experiment with an infinite dose could identify the formulation which exhibited the highest steady-state skin concentration of cosmetic active ingredients. In addition, experiment with mixture formulation might reveal changes in skin permeability associated with changes in thermodynamic activity of IPMP after co-application of several formulations on the skin.

著者

藤井 まき子

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.77, no.4, pp.197-200, 2017-07-01 (Released:2017-07-01)

参考文献数

5

著者

藤井 まき子

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.49, no.5, pp.400-404, 2013-05-01 (Released:2016-09-26)

著者

近藤 昌夫 藤井 まき子 八木 清仁 渡辺 善照

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.127, no.4, pp.601-609, 2007 (Released:2007-04-01)

参考文献数

47

被引用文献数

1 1

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Passing of drugs across epithelial cell sheets and endothelial cell sheets is an obligatory step in the absorption of a drug. The passing routes of drugs are classified into transcellular and paracellular pathways. The transcellular route has been widely investigated and is used in clinical therapy. In contrast, drug delivery using the paracellular route has never been fully developed. Sodium caprate is the only absorption-enhancer of drugs that uses the paracellular route. Tight junctions (TJs) exist between adjacent cells in epithelial and endothelial cell sheets, and they play a role in sealing the cell sheets. Therefore, we must modulate the TJ barrier for drug delivery using paracellular route. In this review, we describe barriology, including very recent topics, and overview absorption-enhancers from the perspective of barriology.