4 0 0 0 OA シナールによる色素沈着症の治験
- 著者
- 藤浪 得二 蔭山 亮市 森田 吉和
- 出版者
- 日本皮膚科学会大阪地方会
- 雑誌
- 皮膚 (ISSN:00181390)
- 巻号頁・発行日
- vol.5, no.3, pp.211-222, 1963 (Released:2010-08-25)
- 参考文献数
- 13
3 0 0 0 OA 化学構造と皮膚刺戟との関係
- 著者
- 藤浪 得二 相模 成一郎 外山 孟生 阪口 啓一 山本 三郎 山崎 果 畑中 茂 山本 義彦 秋本 祐三
- 出版者
- Meeting of Osaka Dermatological Association
- 雑誌
- 皮膚 (ISSN:00181390)
- 巻号頁・発行日
- vol.4, no.3-4, pp.193-204, 1962 (Released:2010-08-25)
The skin irritating effect of various compounds was examined and the following results were obtained.1) Alcohols and esters are, in general, non-irritating effect. Acids, lactones and phenolshave a slight irritating effect. Aldehydes are strongly irritating and halogen compounds have also a strong irritating action.2) The greater the degree of unsaturation, the stronger is the irritating effect. Double bond compounds, especially, have a strong irritating action.3) Ketones are slightly irritating but those which are readily enolized have a strong irritating action.4) The irritability of aromatic aldehydes differs according to the type and position of the substituting radical.5) Water soluble but fat insoluble and water insoluble compounds are non-irritating. Skin irritants have the property of being both water and fat soluble in a certain ratio.
